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NK Papers Q1 2008

Volker Huppert — Sat, 14 Jun 2008 11:11:28 GMT

Summary:

==March 17th, Blood Table of Contents & MeltwaterNews NKG2D==
Claudia Carlino, Helena Stabile, Stefania Morrone, Roberta Bulla, Alessandra Soriani, Chiara Agostinis, Fleur Bossi, Carlo Mocci, Filippo Sarazani, Francesco Tedesco, Angela Santoni, and Angela Gismondi 
'''Recruitment of circulating NK cells through decidual tissues: a possible mechanism controlling NK cell accumulation in the uterus during early pregnancy''' 
[http://bloodjournal.hematologylibrary.org/cgi/content/abstract/111/6/3108?etoc Blood 2008;111 3108-3115]

Evren Alici, Tolga Sutlu, Bo Bjorkstrand, Mari Gilljam, Birgitta Stellan, Hareth Nahi, Hernan Concha Quezada, Gosta Gahrton, Hans-Gustaf Ljunggren, and M. Sirac Dilber 
'''Autologous antitumor activity by NK cells expanded from myeloma patients using GMP-compliant components''' 
[http://bloodjournal.hematologylibrary.org/cgi/content/abstract/111/6/3155?etoc Blood 2008;111 3155-3162] (see below)

Mercedes B. Fuertes, MarÃa V. Girart, Luciana L. Molinero, Carolina I. Domaica, Lucas E. Rossi, MarÃa M. Barrio, JosÃ© Mordoh, Gabriel A. Rabinovich, and Norberto W. Zwirner 
'''Intracellular Retention of the NKG2D Ligand MHC Class I Chain-Related Gene A in Human Melanomas Confers Immune Privilege and Prevents NK Cell-Mediated Cytotoxicity''' 
[http://www.jimmunol.org/cgi/content/abstract/180/7/4606 The Journal of Immunology, 2008, 180: 4606-4614.]

==March 16th, PubCrawler==
Levinson RD, Du Z, Luo L, Monnet D, Tabary T, Brezin AP, Zhao L, Gjertson DW, Holland GN, Reed EF, Cohen JH, Rajalingam R. 
'''Combination of KIR and HLA gene variants augments the risk of developing birdshot chorioretinopathy in HLA-A*29-positive individuals.''' 
Genes Immun. 2008 Mar 13;. Epub, [[PMID:18340360]]

Lanier LL. 
'''Evolutionary struggles between NK cells and viruses.''' 
Nat Rev Immunol. 2008 Mar 14;. Epub, [[PMID:18340344]]

Gao N, Jennings P, Yuan D. 
'''Requirements for the natural killer cell-mediated induction of IgG1 and IgG2a expression in B lymphocytes.''' 
Int Immunol. 2008 Mar 13;. Epub, [[PMID:18339657]]

Hoare HL, Sullivan LC, Clements CS, Ely LK, Beddoe T, Henderson KN, Lin J, Reid HH, Brooks AG, Rossjohn J. 
'''Subtle Changes in Peptide Conformation Profoundly Affect Recognition of the Non-Classical MHC Class I Molecule HLA-E by the CD94-NKG2 Natural Killer Cell Receptors.''' 
J Mol Biol. 2008 Feb 12;. Epub, [[PMID:18339401]]

Nakajima S, Hida S, Taki S. 
'''IL-15 inhibits pre-B cell proliferation by selectively expanding Mac-1(+)B220(+) NK cells.''' 
Biochem Biophys Res Commun. 2008 Mar 10;. Epub, [[PMID:18339305]]

Millman AC, Salman M, Dayaram YK, Connell ND, Venketaraman V. 
'''Natural Killer Cells, Glutathione, Cytokines, and Innate Immunity Against Mycobacterium tuberculosis.''' 
J Interferon Cytokine Res. 2008 Mar;28(3):153-65., [[PMID:18338948]]

Li Q, Morimoto K, Kobayashi M, Inagaki H, Katsumata M, Hirata Y, Hirata K, Suzuki H, Li YJ, Wakayama Y, Kawada T, Park BJ, Ohira T, Matsui N, Kagawa T, Miyazaki Y, Krensky AM. 
'''Visiting a forest, but not a city, increases human natural killer activity and expression of anti-cancer proteins.''' 
Int J Immunopathol Pharmacol. 2008 Jan-Mar;21(1):117-27., [[PMID:18336737]]

Kim HR, Kim K, Lee KH, Kim SJ, Kim J. 
'''Inhibition of casein kinase 2 enhances the death ligand- and natural kiler cell-induced hepatocellular carcinoma cell death.''' 
Clin Exp Immunol. 2008 Mar 10;. Epub, [[PMID:18336591]]

Reschner A, Hubert P, Delvenne P, Boniver J, Jacobs N. 
'''Innate lymphocyte and dendritic cell cross-talk: a key factor in the regulation of the immune response.''' 
Clin Exp Immunol. 2008 Mar 10;. Epub, [[PMID:18336590]]

Jacques A, Bleau C, Martin JP, Lamontagne L. 
'''Intrahepatic endothelial and Kupffer cells involved in immunosuppressive cytokines and natural killer (NK)/NK T cell disorders in viral acute hepatitis.''' 
Clin Exp Immunol. 2008 Mar 10;. Epub, [[PMID:18336588]]

Petrie EJ, Clements CS, Lin J, Sullivan LC, Johnson D, Huyton T, Heroux A, Hoare HL, Beddoe T, Reid HH, Wilce MC, Brooks AG, Rossjohn J. 
'''CD94-NKG2A recognition of human leukocyte antigen (HLA)-E bound to an HLA class I leader sequence.''' 
J Exp Med. 2008 Mar 10;. Epub, [[PMID:18332182]]

Huang Y, Chen A, Li X, Chen Z, Zhang W, Song Y, Gurner D, Gardiner D, Basu S, Ho DD, Tsuji M. 
'''Enhancement of HIV DNA vaccine immunogenicity by the NKT cell ligand, alpha-galactosylceramide.''' 
Vaccine. 2008 Feb 20;. Epub, [[PMID:18329757]]

Rasool ST, Tang H, Wu J, Li W, Mukhtar MM, Zhang J, Mu Y, Xing HX, Wu J, Zhu Y. 
'''Increased level of IL-32 during human immunodeficiency virus infection suppresses HIV replication.''' 
Immunol Lett. 2008 Feb 11;. Epub, [[PMID:18329725]]

Johnson WC, Bastos RG, Davis WC, Goff WL. 
'''Bovine WC1(-)gammadeltaT cells incubated with IL-15 express the natural cytotoxicity receptor CD335 (NKp46) and produce IFN-gamma in response to exogenous IL-12 and IL-18.''' 
Dev Comp Immunol. 2008 Feb 22;. Epub, [[PMID:18329100]]

Yamagiwa S, Matsuda Y, Ichida T, Honda Y, Takamura M, Sugahara S, Ishikawa T, Ohkoshi S, Sato Y, Aoyagi Y. 
'''Sustained response to interferon-alpha plus ribavirin therapy for chronic hepatitis C is closely associated with increased dynamism of intrahepatic natural killer and natural killer T cells.''' 
Hepatol Res. 2008 Mar 4;. Epub, [[PMID:18328072]]

Granucci F, Zanoni I, Ricciardi-Castagnoli P. 
'''Central role of dendritic cells in the regulation and deregulation of immune responses.''' 
Cell Mol Life Sci. 2008 Mar 10;. Epub, [[PMID:18327662]]

Lonigro L, Mirabile E, Munda S, Barchitta M, Bottino D, Fazzio A, Di Cataldo A, Agodi A, SchilirÃƒÂ² G. 
'''Association between high expression of natural killer related-genes (NCAM/CD94) and early death during induction in children with acute myeloid leukemia.''' 
Leukemia. 2008 Mar 6;. Epub, [[PMID:18323797]]

Wakao H, Wakao R, Sakata S, Iwabuchi K, Oda A, Fujita H. 
'''In vitro induction of natural killer T cells from embryonic stem cells prepared using somatic cell nuclear transfer.''' 
FASEB J. 2008 Mar 6;. Epub, [[PMID:18323403]]

Emoto Y, Yoshizawa I, Hurwitz R, Brinkmann V, Kaufmann SH, Emoto M. 
'''Role of interleukin-12 in determining differential kinetics of invariant natural killer T cells in response to differential burden of Listeria monocytogenes.''' 
Microbes Infect. 2007 Dec 3;. Epub, [[PMID:18321748]]

Greeson JM, Hurwitz BE, Llabre MM, Schneiderman N, Penedo FJ, Klimas NG. 
'''Psychological distress, killer lymphocytes and disease severity in HIV/AIDS.''' 
Brain Behav Immun. 2008 Mar 3;. Epub, [[PMID:18321678]]

Singh P, Kaur G, Sharma G, Mehra NK. 
'''Immunogenetic basis of HIV-1 infection, transmission and disease progression.''' 
Vaccine. 2008 Feb 4;. Epub, [[PMID:18321617]]

Guia S, Cognet C, de Beaucoudrey L, Tessmer MS, Jouanguy E, Berger C, Filipe-Santos O, Feinberg J, Camcioglu Y, Levy J, Al Jumaah S, Al-Hajjar S, Stephan JL, Fieschi C, Abel L, Brossay L, Casanova JL, Vivier E. 
'''A role for interleukin-12/23 in the maturation of human Natural Killer and CD56+ T cells in vivo.''' 
Blood. 2008 Mar 4;. Epub, [[PMID:18319400]]

Malmberg KJ, Bryceson YT, Carlsten M, Andersson S, BjÃƒÂ¶rklund A, BjÃƒÂ¶rkstrÃƒÂ¶m NK, Baumann BC, Fauriat C, Alici E, Dilber MS, Ljunggren HG. 
'''NK cell-mediated targeting of human cancer and possibilities for new means of immunotherapy.''' 
Cancer Immunol Immunother. 2008 Mar 4;. Epub, [[PMID:18317755]]

Boulet S, Sharafi S, Simic N, Bruneau J, Routy JP, Tsoukas CM, Bernard NF. 
'''Increased proportion of KIR3DS1 homozygotes in HIV-exposed uninfected individuals.''' 
AIDS. 2008 Mar 12;22(5):595-9., [[PMID:18317000]]

ValÃƒÂ©s-GÃƒÂ³mez M, Chisholm SE, Cassady-Cain RL, Roda-Navarro P, Reyburn HT. 
'''Selective induction of expression of a ligand for the NKG2D receptor by proteasome inhibitors.''' 
Cancer Res. 2008 Mar 1;68(5):1546-54., [[PMID:18316620]]

Palumbo JS, Barney KA, Blevins EA, Shaw MA, Flick MJ, Kombrinck KW, Talmage KE, Souri M, Ichinose A, Degen JL. 
'''Factor XIII transglutaminase supports hematogenous tumor cell metastasis through a mechanism dependent on natural killer cell function.''' 
J Thromb Haemost. 2008 Feb 25;. Epub, [[PMID:18315549]]

Kawashima M, Maeda N, Adachi Y, Takeuchi T, Yamamoto Y, Izumiya C, Hayashi K, Furihata M, Udaka K, Fukaya T. 
'''Human leukocyte antigen-G, a ligand for the natural killer receptor KIR2DL4, is expressed by eutopic endometrium only in the menstrual phase.''' 
Fertil Steril. 2008 Mar 1;. Epub, [[PMID:18314122]]

Chan A, Filer A, Parsonage G, Kollnberger S, Gundle R, Buckley CD, Bowness P. 
'''Mediation of the proinflammatory cytokine response in rheumatoid arthritis and spondylarthritis by interactions between fibroblast-like synoviocytes and natural killer cells.''' 
Arthritis Rheum. 2008 Feb 29;58(3):707-717. Epub, [[PMID:18311795]]

Vitale C, Cottalasso F, Montaldo E, Moretta L, Mingari MC. 
'''Methylprednisolone induces preferential and rapid differentiation of CD34+ cord blood precursors toward NK cells.''' 
Int Immunol. 2008 Feb 28;. Epub, [[PMID:18310065]]

==March 2nd, PubCrawler==
Erlach KC, BÃƒÂ¶hm V, Knabe M, Deegen P, Reddehase MJ, Podlech J. 
'''Activation of hepatic natural killer cells and control of liver-adapted lymphoma in the murine model of cytomegalovirus infection.''' 
Med Microbiol Immunol. 2008 Feb 29;. Epub, [[PMID:18309517]]

Im JS, Kang TJ, Lee SB, Kim CH, Lee SH, Venkataswamy MM, Serfass ER, Chen B, Illarionov PA, Besra GS, Jacobs WR Jr, Chae GT, Porcelli SA. 
'''Alteration of the relative levels of iNKT cell subsets is associated with chronic mycobacterial infections.''' 
Clin Immunol. 2008 Feb 26;. Epub, [[PMID:18308638]]

Yoshida O, Akbar F, Miyake T, Abe M, Matsuura B, Hiasa Y, Onji M. 
'''Impaired dendritic cell functions because of depletion of natural killer cells disrupt antigen-specific immune responses in mice: restoration of adaptive immunity in natural killer-depleted mice by antigen-pulsed dendritic cell.''' 
Clin Exp Immunol. 2008 Feb 25;. Epub, [[PMID:18307521]]

Tumurkhuu G, Koide N, Dagvadorj J, Morikawa A, Hassan F, Islam S, Naiki Y, Mori I, Yoshida T, Yokochi T. 
'''The mechanism of development of acute lung injury in lethal endotoxic shock using alpha-galactosylceramide sensitization.''' 
Clin Exp Immunol. 2008 Feb 25;. Epub, [[PMID:18307519]]

Long BR, Ndhlovu LC, Oksenberg JR, Lanier LL, Hecht FM, Nixon DF, Barbour JD. 
'''KIR3DS1 Conferral of Enhanced Natural Killer Cell Function in Early HIV-1 Infection.''' 
J Virol. 2008 Feb 27;. Epub, [[PMID:18305035]]

Rolf J, Berntman E, StenstrÃƒÂ¶m M, Smith EM, MÃƒÂ¥nsson R, Stenstad H, Yamagata T, Agace W, Sigvardsson M, Cardell SL. 
'''Molecular profiling reveals distinct functional attributes of CD1d-restricted natural killer (NK) T cell subsets.''' 
Mol Immunol. 2008 Feb 25;. Epub, [[PMID:18304639]]

Nogusa S, Ritz BW, Kassim SH, Jennings SR, Gardner EM. 
'''Characterization of age-related changes in natural killer cells during primary influenza infection in mice.''' 
Mech Ageing Dev. 2008 Jan 20;. Epub, [[PMID:18304606]]

Chowdhury D, Lieberman J. 
'''Death by a Thousand Cuts: Granzyme Pathways of Programmed Cell Death.''' 
Annu Rev Immunol. 2007 Nov 28;. Epub, [[PMID:18304003]]

Swain MG. 
'''Hepatic NKT cells: friend or foe?''' 
Clin Sci (Lond). 2008 Apr;114(7):457-66., [[PMID:18302533]]

Haeryfar SM. 
'''Invariant natural killer T cells in immune surveillance and tumor immunotherapy: perspectives and potentialsysms.''' 
Arch Iran Med. 2008 Apr;11(2):186-95., [[PMID:18298297]]

McCullar V, Oostendorp R, Panoskaltsis-Mortari A, Yun G, Lutz CT, Wagner JE, Miller JS. 
'''Mouse fetal and embryonic liver cells differentiate human umbilical cord blood progenitors into CD56-negative natural killer cell precursors in the absence of interleukin-15.''' 
Exp Hematol. 2008 Feb 22;. Epub, [[PMID:18295962]]

Zheng X, Wang Y, Wei H, Ling B, Sun R, Tian Z. 
'''Bcl-xL is associated with the anti-apoptotic effect of IL-15 on the survival of CD56(dim) natural killer cells.''' 
Mol Immunol. 2008 Feb 22;. Epub, [[PMID:18295891]]

Yu Y, Wang Y, Feng M. 
'''Human leukocyte antigen-G1 inhibits natural killer cytotoxicity through blocking the activating signal transduction pathway and formation of activating immunologic synapse.''' 
Hum Immunol. 2008 Jan;69(1):16-23., [[PMID:18295671]]

White TC, Chauhan V, Middlebrook AJ, Im JS, Deluca D. 
'''Antibodies to CD1d enhance thymic expression of invariant NKT TCR and increase the presence of NOD thymic invariant NKT cells.''' 
Dev Comp Immunol. 2008 Feb 11;. Epub, [[PMID:18295332]]

Paparistidis N, Papadopoulou C, Chioti A, Papaioannou D, Tsekoura C, Keramitsoglou T, Kontopoulou-Antonopoulou V, Agapitos E, Balafoutas C, Varla-Leftherioti M. 
'''How Valuable is Measurement of Peripheral Blood Natural Killer Cells at the Time of Abortion?''' 
Am J Reprod Immunol. 2008 Feb 21;. Epub, [[PMID:18294356]]

Motohashi S, Nakayama T. 
'''Clinical applications of natural killer T cell-based immunotherapy for cancer.''' 
Cancer Sci. 2008 Feb 21;. Epub, [[PMID:18294290]]

==February 24th, PubCrawler==
Hoskin DW, Mader JS, Furlong SJ, Conrad DM, Blay J. 
'''Inhibition of T cell and natural killer cell function by adenosine and its contribution to immune evasion by tumor cells (Review).''' 
Int J Oncol. 2008 Mar;32(3):527-35., [[PMID:18292929]]

Roy KC, Maricic I, Khurana A, Smith TR, Halder RC, Kumar V. 
'''Involvement of Secretory and Endosomal Compartments in Presentation of an Exogenous Self-Glycolipid to Type II NKT Cells.''' 
J Immunol. 2008 Mar 1;180(5):2942-50., [[PMID:18292516]]

Romero V, Azocar J, ZÃƒÂºÃƒÂ±iga J, Clavijo OP, Terreros D, Gu X, Husain Z, Chung RT, Amos C, Yunis EJ. 
'''Interaction of NK inhibitory receptor genes with HLA-C and MHC class II alleles in Hepatitis C virus infection outcome.''' 
Mol Immunol. 2008 Feb 18;. Epub, [[PMID:18289678]]

Oh MJ, Croy BA. 
'''A Map of Relationships Between Uterine Natural Killer Cells and Progesterone Receptor Expressing Cells During Mouse Pregnancy.''' 
Placenta. 2008 Feb 18;. Epub, [[PMID:18289671]]

Maki G, Hayes GM, Naji A, Tyler T, Carosella ED, Rouas-Freiss N, Gregory SA. 
'''NK resistance of tumor cells from multiple myeloma and chronic lymphocytic leukemia patients: implication of HLA-G.''' 
Leukemia. 2008 Feb 21;. Epub, [[PMID:18288133]]

McSharry BP, Burgert HG, Owen DP, Stanton RJ, Prod'homme V, Sester M, Koebernick K, Groh V, Spies T, Cox S, Little AM, Wang EC, Tomasec P, Wilkinson GW. 
'''Adenovirus E3/19K Promotes Evasion of NK Cell Recognition by Intracellular Sequestration of the NKG2D Ligands MICA and MICB.''' 
J Virol. 2008 Feb 20;. Epub, [[PMID:18287244]]

Kim S, Sunwoo JB, Yang L, Choi T, Song YJ, French AR, Vlahiotis A, Piccirillo JF, Cella M, Colonna M, Mohanakumar T, Hsu KC, Dupont B, Yokoyama WM. 
'''HLA alleles determine differences in human natural killer cell responsiveness and potency.''' 
Proc Natl Acad Sci U S A. 2008 Feb 19;. Epub, [[PMID:18287063]]

Li C, Ge B, Nicotra M, Stern JN, Kopcow HD, Chen X, Strominger JL. 
'''JNK MAP kinase activation is required for MTOC and granule polarization in NKG2D-mediated NK cell cytotoxicity.''' 
Proc Natl Acad Sci U S A. 2008 Feb 19;. Epub, [[PMID:18287025]]

Marcondes AM, Mhyre AJ, Stirewalt DL, Kim SH, Dinarello CA, Deeg HJ. 
'''Dysregulation of IL-32 in myelodysplastic syndrome and chronic myelomonocytic leukemia modulates apoptosis and impairs NK function.''' 
Proc Natl Acad Sci U S A. 2008 Feb 19;. Epub, [[PMID:18287021]]

Liang X, Graham DK. 
'''Natural killer cell neoplasms.''' 
Cancer. 2008 Feb 19;. Epub, [[PMID:18286525]]

Tamura Y, Teng A, Nozawa R, Takamoto-Matsui Y, Ishii Y. 
'''Characterization of the immature dendritic cells and cytotoxic cells both expanded after activation of invariant NKT cells with alpha-galactosylceramide in vivo.''' 
Biochem Biophys Res Commun. 2008 Feb 16;. Epub, [[PMID:18284915]]

Goldman-Wohl D, Yagel S. 
'''NK cells and pre-eclampsia.''' 
Reprod Biomed Online. 2008 Feb;16(2):227-31., [[PMID:18284877]]

Bilinski MJ, Thorne JG, Oh MJ, Leonard S, Murrant C, Tayade C, Croy BA. 
'''Uterine NK cells in murine pregnancy.''' 
Reprod Biomed Online. 2008 Feb;16(2):218-26., [[PMID:18284876]]

Szekeres-Bartho J. 
'''Regulation of NK cell cytotoxicity during pregnancy.''' 
Reprod Biomed Online. 2008 Feb;16(2):211-7., [[PMID:18284875]]

Santoni A, Carlino C, Gismondi A. 
'''Uterine NK cell development, migration and function.''' 
Reprod Biomed Online. 2008 Feb;16(2):202-10., [[PMID:18284874]]

Schmitt C, Ghazi B, Bensussan A. 
'''NK cells and surveillance in humans.''' 
Reprod Biomed Online. 2008 Feb;16(2):192-201., [[PMID:18284872]]

Yokoyama WM, Riley JK. 
'''NK cells and their receptors.''' 
Reprod Biomed Online. 2008 Feb;16(2):173-91., [[PMID:18284871]]

Chaouat G. 
'''Introduction.''' 
Reprod Biomed Online. 2008 Feb;16(2):170-2., [[PMID:18284870]]

Klingemann H, Boissel L. 
'''Targeted cellular therapy with natural killer cells.''' 
Horm Metab Res. 2008 Feb;40(2):122-5., [[PMID:18283630]]

Jacobs B, Wuttke M, Papewalis C, Fenk R, StÃƒÂ¼ssgen C, Baehring T, Schinner S, Raffel A, Seissler J, Schott M. 
'''Characterization of Monocyte-derived IFNalpha-generated Dendritic Cells.''' 
Horm Metab Res. 2008 Feb;40(2):117-21., [[PMID:18283629]]

Ullrich E, Chaput N, Zitvogel L. 
'''[[Killer Dendritic Cell]]s and their Potential Role in [[Immunotherapy]].''' 
Horm Metab Res. 2008 Feb;40(2):75-81., [[PMID:18283624]]

Congy-Jolivet N, Bolzec A, Ternant D, Ohresser M, Watier H, Thibault G. 
'''Fc gamma RIIIa expression is not increased on natural killer cells expressing the Fc gamma RIIIa-158V allotype.''' 
Cancer Res. 2008 Feb 15;68(4):976-80., [[PMID:18281470]]

Zhang C, Zhang J, Niu J, Zhang J, Tian Z. 
'''Interleukin-15 improves cytotoxicity of natural killer cells via up-regulating NKG2D and cytotoxic effector molecule expression as well as STAT1 and ERK1/2 phosphorylation.''' 
Cytokine. 2008 Feb 14;. Epub, [[PMID:18280748]]

Zhong M, Kadota Y, Shimizu Y, Gohda E. 
'''Induction of cytolytic activity and interferon-gamma production in murine natural killer cells by polymyxins B and E.''' 
Int Immunopharmacol. 2008 Mar;8(3):508-513., [[PMID:18279806]]

Martinez-Borra J, Khakoo SI. 
'''Speed and selection in the evolution of killer-cell immunoglobulin-like receptors.''' 
Int J Immunogenet. 2008 Feb 11;. Epub, [[PMID:18279370]]

Zeytin H, Reali E, Zaharoff DA, Rogers CJ, Schlom J, Greiner JW. 
'''Targeted Delivery of Murine IFN-gamma Using a Recombinant Fowlpox Virus: NK Cell Recruitment to Regional Lymph Nodes and Priming of Tumor-Specific Host Immunity.''' 
J Interferon Cytokine Res. 2008 Feb;28(2):73-87., [[PMID:18279103]]

Chanan-Khan AA, Cheson BD. 
'''Lenalidomide for the Treatment of B-Cell Malignancies.''' 
J Clin Oncol. 2008 Feb 19;. Epub, [[PMID:18285605]]

==February 22nd, MeltWaterNews NKG2D==
[http://www.newsrx.com/library/topics/Ovarian-Cancer/914.html Peritoneal natural killer cells from epithelial ovarian cancer patients show an altered phenotype and bind to the tumour marker MUC16 (CA125) @ NewsRx]

[http://calibre.mworld.com/m/m.w?lp=GetStory&id=294699471 Cellular & Molecular Immunology (High expression of NKG2A/CD94 and low expression of granzyme B are associated with reduced cord blood NK cell activity. Cellular & Molecular Immunology, 2007;4(5):377-382) @ Calibre MacroWorld]

[http://calibre.mworld.com/m/m.w?lp=GetStory&id=294677131 Clinical Cancer Research (NKG2D-Mediated antitumor activity by tumor-infiltrating lymphocytes and antigen-specific T-cell clones isolated from melanoma patients. Clinical Cancer Research, 2007;13(24):7459-7468) @ Calibre MacroWorld]

[http://www.jimmunol.org/cgi/content/abstract/180/5/2999 Rat CD4+CD8+ Macrophages Kill Tumor Cells through an NKG2D- and Granzyme/Perforin-Dependent Mechanism]

==February 19th, PubCrawler==
Chang YJ, Zhao XY, Huang XJ. 
'''Effects of the NK Cell Recovery on Outcomes of Unmanipulated Haploidentical Blood and Marrow Transplantation for Patients with Hematologic Malignancies.''' 
Biol Blood Marrow Transplant. 2008 Mar;14(3):323-334., [[PMID:18275899]]

Boyiadzis M, Memon S, Carson J, Allen K, Szczepanski MJ, Vance BA, Dean R, Bishop MR, Gress RE, Hakim FT. 
'''Up-regulation of NK Cell Activating Receptors Following Allogeneic Hematopoietic Stem Cell Transplantation under a Lymphodepleting Reduced Intensity Regimen is Associated with Elevated IL-15 Levels.''' 
Biol Blood Marrow Transplant. 2008 Mar;14(3):290-300., [[PMID:18275895]]

Velilla PA, Shata MT, Lages CS, Ying J, Fichtenbaum CJ, Chougnet C. 
'''Effect of Low-Dose IL-2 Immunotherapy on Frequency and Phenotype of Regulatory T Cells and NK Cells in HIV/HCV-Coinfected Patients.''' 
AIDS Res Hum Retroviruses. 2008 Jan;24(1):52-61., [[PMID:18275348]]

Arina A, Murillo O, Dubrot J, Azpilikueta A, Gabari I, Perez-Gracia JL, Alfaro C, Berasain C, Prieto J, Ferrini S, Hervas-Stubbs S, Melero I. 
'''Interleukin-15 liver gene transfer increases the number and function of IKDCs and NK cells.''' 
Gene Ther. 2008 Feb 14;. Epub, [[PMID:18273053]]

Parker AK, Yokoyama WM, Corbett JA, Chen N, Buller RM. 
'''Primary naive and interleukin-2-activated natural killer cells do not support efficient ectromelia virus replication.''' 
J Gen Virol. 2008 Mar;89(Pt 3):751-9., [[PMID:18272767]]

Kheradmand T, Trivedi PP, Wolf NA, Roberts PC, Swanborg RH. 
'''Characterization of a subset of bone marrow-derived natural killer cells that regulates T cell activation in rats.''' 
J Leukoc Biol. 2008 Feb 13;. Epub, [[PMID:18272589]]

Molano A, Illarionov PA, Besra GS, Putterman C, Porcelli SA. 
'''Modulation of invariant natural killer T cell cytokine responses by indoleamine 2,3-dioxygenase.''' 
Immunol Lett. 2008 Jan 28;. Epub, [[PMID:18272236]]

Yamaura A, Hotta C, Nakazawa M, Van Kaer L, Minami M. 
'''Human invariant V{alpha}24+ natural killer T cells acquire regulatory functions by interacting with IL-10-treated dendritic cells.''' 
Blood. 2008 Feb 13;. Epub, [[PMID:18270329]]

Rosenberger CM, Clark AE, Treuting PM, Johnson CD, Aderem A. 
'''ATF3 regulates MCMV infection in mice by modulating IFN-{gamma} expression in natural killer cells.''' 
Proc Natl Acad Sci U S A. 2008 Feb 11;. Epub, [[PMID:18268321]]

Fildes JE, Yonan N, Tunstall K, Walker AH, Griffiths-Davies L, Bishop P, Leonard CT. 
'''Natural killer cells in peripheral blood and lung tissue are associated with chronic rejection after lung transplantation.''' 
J Heart Lung Transplant. 2008 Feb;27(2):203-7., [[PMID:18267228]]

Fang M, Lanier LL, Sigal LJ. 
'''A Role for [[NKG2D]] in NK Cell-Mediated Resistance to Poxvirus Disease.''' 
PLoS Pathog. 2008 Feb 8;4(2):e30. Epub, [[PMID:18266471]]

Strowig T, Brilot F, Arrey F, Bougras G, Thomas D, Muller WA, MÃ¼nz C. 
'''[[Tonsilar NK Cell]]s Restrict B Cell Transformation by the Epstein-Barr Virus via IFN-gamma.''' 
PLoS Pathog. 2008 Feb 8;4(2):e27. Epub, [[PMID:18266470]], [[http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=18266470 Free Fulltext @ PubMedCentral]], [[http://pathogens.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.ppat.0040027&ct=1 Free Fulltext @ PLoS]]

Gros F, Cabillic F, Toutirais O, Maux AL, Sebti Y, Amiot L. 
'''Soluble HLA-G molecules impair natural killer/dendritic cell crosstalk via inhibition of dendritic cells.''' 
Eur J Immunol. 2008 Feb 11;. Epub, [[PMID:18266268]]

Boos MD, Ramirez K, Kee BL. 
'''Extrinsic and intrinsic regulation of early [[natural killer cell development]].''' 
Immunol Res. 2008;40(3):193-207., [[PMID:18266115]]

Hiby SE, Regan L, Lo W, Farrell L, Carrington M, Moffett A. 
'''Association of maternal [[killer-cell immunoglobulin-like receptor]]s and parental [[HLA-C]] genotypes with recurrent miscarriage.''' 
Hum Reprod. 2008 Feb 8;. Epub, [[PMID:18263639]]

Shaulov A, Yue S, Wang R, Joyce RM, Balk SP, Kim HT, Avigan DE, Uhl L, Sackstein R, Exley MA. 
'''Peripheral blood progenitor cell product contains Th1-biased noninvariant CD1d-reactive natural killer T cells: Implications for posttransplant survival.''' 
Exp Hematol. 2008 Feb 6;. Epub, [[PMID:18261838]]

==February 11th, Blood Table of Contents==
Gillian A. Lang, T. Scott Devera, and Mark L. Lang 
'''Requirement for CD1d expression by B cells to stimulate NKT cell-enhanced antibody production''' 
[http://bloodjournal.hematologylibrary.org/cgi/content/abstract/111/4/2158?etoc Blood 2008;111 2158-2162]

==February 10th, PubCrawler==
Lenac T, Arapovic J, Traven L, Krmpotic A, Jonjic S. 
'''Murine cytomegalovirus regulation of NKG2D ligands.''' 
Med Microbiol Immunol. 2008 Feb 8;. Epub, [[PMID:18259774]]

Krzewski K, Chen X, Strominger JL. 
'''WIP is essential for lytic granule polarization and NK cell cytotoxicity.''' 
Proc Natl Acad Sci U S A. 2008 Feb 7;. Epub, [[PMID:18258743]]

Diepstra A, Poppema S, Boot M, Visser L, Nolte IM, Niens M, Te Meerman GJ, van den Berg A. 
'''HLA-G protein expression as a potential immune escape mechanism in classical Hodgkin's lymphoma.''' 
Tissue Antigens. 2008 Mar;71(3):219-26., [[PMID:18257895]]

Clark DA, Wong K, Banwatt D, Chen Z, Liu J, Lee L, Gorczynski RM, Blajchman MA. 
'''CD200-dependent and nonCD200-dependant pathways of NK cell suppression by human IVIG.''' 
J Assist Reprod Genet. 2008 Feb 7;. Epub, [[PMID:18256920]]

Watanabe M, Nakamura Y, Matsuzuka F, Takamura Y, Miyauchi A, Iwatani Y. 
'''Decrease of Intrathyroidal CD161 (+)Valpha24(+)Vbeta11(+) NKT Cells in Graves' Disease.''' 
Endocr J. 2008 Feb 4;. Epub, [[PMID:18250538]]

Kim DH, Chang WS, Lee YS, Lee KA, Kim YK, Kwon BS, Kang CY. 
'''4-1BB Engagement Costimulates NKT Cell Activation and Exacerbates NKT Cell Ligand-Induced Airway Hyperresponsiveness and Inflammation.''' 
J Immunol. 2008 Feb 15;180(4):2062-8., [[PMID:18250411]]

VelÃ¡zquez P, Cameron TO, Kinjo Y, Nagarajan N, Kronenberg M, Dustin ML. 
'''Cutting edge: activation by innate cytokines or microbial antigens can cause arrest of natural killer T cell patrolling of liver sinusoids.''' 
J Immunol. 2008 Feb 15;180(4):2024-8., [[PMID:18250405]]

Pichavant M, Goya S, Meyer EH, Johnston RA, Kim HY, Matangkasombut P, Zhu M, Iwakura Y, Savage PB, Dekruyff RH, Shore SA, Umetsu DT. 
'''Ozone exposure in a mouse model induces airway hyperreactivity that requires the presence of natural killer T cells and IL-17.''' 
J Exp Med. 2008 Feb 4;. Epub, [[PMID:18250191]]

Othoro C, Moore JM, Wannemuehler KA, Moses S, Lal A, Otieno J, Nahlen B, Slutsker L, Shi YP. 
'''Elevated IFN-{gamma} producing NK cells, CD45RO memory-like T cells and CD4 T cells are associated with protection against malaria infection in pregnancy.''' 
Infect Immun. 2008 Feb 4;. Epub, [[PMID:18250175]]

Ahlenstiel G, Martin MP, Gao X, Carrington M, Rehermann B. 
'''Distinct KIR/HLA compound genotypes affect the kinetics of human antiviral natural killer cell responses.''' 
J Clin Invest. 2008 Feb 1;. Epub, [[PMID:18246204]]

Schellekens J, Rozemuller EH, Petersen EJ, van den Tweel JG, Verdonck LF, Tilanus MG. 
'''Activating KIRs exert a crucial role on relapse and overall survival after HLA-identical sibling transplantation.''' 
Mol Immunol. 2008 Feb 1;. Epub, [[PMID:18243319]]

Sun LL, Han Y, Chen JH, Yao YQ. 
'''Down-regulation of HLA-G boosted natural killer cell-mediated cytolysis in JEG-3 cells cultured in vitro.''' 
Fertil Steril. 2008 Feb 1;. Epub, [[PMID:18243178]]

Rezvani AR, Storb RF. 
'''Separation of graft-vs.-tumor effects from graft-vs.-host disease in allogeneic hematopoietic cell transplantation.''' 
J Autoimmun. 2008 Jan 30;. Epub, [[PMID:18242060]]

Nowicki MJ, Vigen C, Mack WJ, Seaberg E, Landay A, Anastos K, Young M, Minkoff H, Greenblatt R, Levine AM. 
'''Association of Cells with Natural Killer (NK) and NKT Immunophenotype with Incident Cancers in HIV-Infected Women.''' 
AIDS Res Hum Retroviruses. 2008 Feb 1;. Epub, [[PMID:18240964]]

Horn P, Kalz A, Lim CL, Pyne D, Saunders P, Mackinnon L, Peake J, Suzuki K. 
'''Exercise-recruited NK cells display exercise-associated eHSP-70.''' 
Exerc Immunol Rev. 2007;13:100-11., [[PMID:18198664]]

==February 3rd, PubCrawler==
Li G, Huang W, Xia Q, Yang K, Liu R, Zhu H, Jiang W. 
'''Role of uterine natural killer cells in angiogenesis of human decidua of the first-trimester pregnancy.''' 
Sci China C Life Sci. 2008 Apr;51(2):111-9., [[PMID:18239888]]

Thomas M, Boname JM, Field S, Nejentsev S, Salio M, Cerundolo V, Wills M, Lehner PJ. 
'''Down-regulation of [[NKG2D]] and [[NKp80]] ligands by Kaposi's sarcoma-associated herpesvirus K5 protects against NK cell cytotoxicity.''' 
Proc Natl Acad Sci U S A. 2008 Jan 29;. Epub, [[PMID:18230726]], NKref0552 (see below)

Veinotte LL, Halim TY, Takei F. 
'''Unique [[subset]] of natural killer cells develops from progenitors in lymph node.''' 
Blood. 2008 Jan 28;. Epub, [[PMID:18227350]]

Hasenkamp J, Borgerding A, Uhrberg M, Falk C, Chapuy B, Wulf G, Jung W, TrÃ¼mper L, Glass B. 
'''Self-tolerance of Human Natural Killer Cells Lacking Self-HLA-specific Inhibitory Receptors.''' 
Scand J Immunol. 2008 Jan 22;. Epub, [[PMID:18226015]]

Miyazaki Y, Iwabuchi K, Iwata D, Miyazaki A, Kon Y, Niino M, Kikuchi S, Yanagawa Y, Kaer LV, Sasaki H, OnoÃ© K. 
'''Effect of High Fat Diet on NKT Cell Function and NKT Cell-mediated Regulation of Th1 Responses.''' 
Scand J Immunol. 2008 Jan 22;. Epub, [[PMID:18226013]]

Check JH, Sansoucie L, Chern J, Amadi N, Srivastava M, Larece K. 
'''Evidence that progesterone receptor antagonists may help in the treatment of a variety of cancers by locally suppressing natural killer cell activity.''' 
Clin Exp Obstet Gynecol. 2007;34(4):207-11., [[PMID:18225679]]

Brazowski E, Eytan K, Eisenthal A. 
'''In vitro modulation of interleukin-2-mediated human peripheral mononuclear cell proliferation and antitumor cytotoxicity by 5-fluorouracil.''' 
Anticancer Res. 2007 Nov-Dec;27(6B):4135-41., [[PMID:18225584]]

Unni AM, Bondar T, Medzhitov R. 
'''Intrinsic sensor of oncogenic transformation induces a signal for innate immunosurveillance.''' 
Proc Natl Acad Sci U S A. 2008 Jan 25;. Epub, [[PMID:18223157]]

Kahraman A, Barreyro FJ, Bronk SF, Werneburg NW, Mott JL, Akazawa Y, Masuoka HC, Howe CL, Gores GJ. 
'''TRAIL mediates liver injury by the innate immune system in the bile duct-ligated mouse.''' 
Hepatology. 2008 Jan 10;. Epub, [[PMID:18220275]]

==January 31st, MeltWaterNews "NKG2D"==
Mair Thomas, Jessica M. Boname, Sarah Field, Sergey Nejentsev, Mariolina Salio, Vincenzo Cerundolo, Mark Wills, and Paul J. Lehner 
'''Down-regulation of [[NKG2D]] and [[NKp80]] ligands by Kaposi's sarcoma-associated herpesvirus K5 protects against [[NK cell]] cytotoxicity''' 
[http://www.pnas.org/cgi/content/short/0707883105v1 Proc. Natl. Acad. Sci. USA, 10.1073/pnas.0707883105] NKref0552

==January 27th, PubCrawler==
Khan N. 
'''The immunological burden of human cytomegalovirus infection.''' 
Arch Immunol Ther Exp (Warsz). 2007 Sep-Oct;55(5):299-308., [[PMID:18219760]]

Northfield JW, Kasprowicz V, Lucas M, Kersting N, Bengsh B, Kim A, Phillips RE, Walker BD, Thimme R, Lauer G, Klenerman P. 
'''CD161 expression on hepatitis C virus-specific CD8+ T cells suggests a distinct pathway of T cell differentiation.''' 
Hepatology. 2008 Jan 7;47(2):396-406. Epub, [[PMID:18219672]]

Fan YY, Yang BY, Wu CY. 
'''Phenotypic and functional heterogeneity of natural killer cells from umbilical cord blood mononuclear cells.''' 
Immunol Invest. 2008;37(1):79-96., [[PMID:18214801]]

Dayanc BE, Beachy SH, Ostberg JR, Repasky EA. 
'''Dissecting the role of hyperthermia in natural killer cell mediated anti-tumor responses.''' 
Int J Hyperthermia. 2008 Feb;24(1):41-56., [[PMID:18214768]]

Scott GB, Meade JL, Cook GP. 
'''Profiling killers; unravelling the pathways of human natural killer cell function.''' 
Brief Funct Genomic Proteomic. 2008 Jan 21;. Epub, [[PMID:18208863]]

Giancola R, Olioso P, Di Riti M, Capone A, Contento A, Pompetti F, Iacone A. 
'''Evaluation of an automated closed fluid management device for processing [[expand]]ed cytokine-induced killer cells to use in immunotherapy programs for cancer.''' 
Transfusion. 2008 Jan 15;. Epub, [[PMID:18208417]]

JonjiÃ„â€¡ S, BabiÃ„â€¡ M, PoliÃ„â€¡ B, KrmpotiÃ„â€¡ A. 
'''Immune evasion of natural killer cells by viruses.''' 
Curr Opin Immunol. 2008 Jan 16;. Epub, [[PMID:18206359]]

==January 22nd, Blood & JI CiteTrack; Meltwater News NKG2D==
Scott, G. B., Meade, J. L., Cook, G. P. 
'''Profiling killers; unravelling the pathways of human natural killer cell function''' 
[http://bfgp.oxfordjournals.org/cgi/content/abstract/elm037v1?ct Brief Funct Genomic Proteomic 2008 0: p. elm037v1-elm037]

Roy, S., Barnes, P. F., Garg, A., Wu, S., Cosman, D., Vankayalapati, R. 
'''NK Cells Lyse T Regulatory Cells That Expand in Response to an Intracellular Pathogen''' 
[http://www.jimmunol.org/cgi/content/abstract/180/3/1729?ct J Immunol 2008 180: p. 1729-1736], NKref0551

Takada, A., Kasahara, M., Takada, A., Kasahara, M. 
'''Two Novel [[NKG2D]] Ligands of the Mouse H60 Family with Differential Expression Patterns and Binding Affinities to [[NKG2D]]''' 
[http://www.jimmunol.org/cgi/content/abstract/180/3/1729?ct The Journal of Immunology, 2008, 180: 1678-1685.], NKref0550

==January 20th, PubCrawler==
Carrega P, Morandi B, Costa R, Frumento G, Forte G, Altavilla G, Ratto GB, Mingari MC, Moretta L, Ferlazzo G. 
'''Natural killer cells infiltrating human nonsmall-cell lung cancer are enriched in CD56(bright)CD16(-) cells and display an impaired capability to kill tumor cells.''' 
Cancer. 2008 Jan 17;. Epub, [[PMID:18203207]]

Meehan KR, Wu J, Webber SM, Barber A, Szczepiorkowski ZM, Sentman C. 
'''Development of a clinical model for ex vivo expansion of multiple populations of effector cells for adoptive cellular therapy.''' 
Cytotherapy. 2008;10(1):30-7., [[PMID:18202972]]

Reich S, Keitzer R, Schmidt RE, Jacobs R, Varnholt V, Buck D, Herold R, Renz H. 
'''Oculocutaneous albinism accompanied by minor morphologic stigmata and reduced number and function of NK cells. A new variant of NK cell defect?''' 
Eur J Pediatr. 2008 Jan 17;. Epub, [[PMID:18202852]]

Matsumura N, Mandai M, Hamanishi J, Yamaguchi K, Fukuhara K, Yagi H, Higuchi T, Takakura K, Fujii S. 
'''Immunostimulatory effect of Fms-like tyrosine kinase 3 ligand on peripheral monocyte-derived dendritic cells and natural killer cells: Utilization for ovarian cancer treatment.''' 
Oncol Rep. 2008 Feb;19(2):505-15., [[PMID:18202801]]

Sedelies KA, Ciccone A, Clarke CJ, Oliaro J, Sutton VR, Scott FL, Silke J, Susanto O, Green DR, Johnstone RW, Bird PI, Trapani JA, Waterhouse NJ. 
'''Blocking granule-mediated death by primary human NK cells requires both protection of mitochondria and inhibition of caspase activity.''' 
Cell Death Differ. 2008 Jan 18;. Epub, [[PMID:18202705]]

Hayashi T, Tsujii S, Iburi T, Tamanaha T, Yamagami K, Ishibashi R, Hori M, Sakamoto S, Ishii H, Murakami K. 
'''Laughter up-regulates the genes related to NK cell activity in diabetes.''' 
Biomed Res. 2008 Dec;28(6):281-5., [[PMID:18202517]]

Rai A, Chakravarty AK. 
'''Homing of radiolabelled recombinant interleukin-2 activated natural killer cells and their efficacy in adoptive immunotherapy against murine fibrosarcoma.''' 
J Biosci. 2007 Dec;32(7):1299-305., [[PMID:18202454]] NKref0549

Jinushi M, Vanneman M, Munshi NC, Tai YT, Prabhala RH, Ritz J, Neuberg D, Anderson KC, Carrasco DR, Dranoff G. 
'''MHC class I chain-related protein A antibodies and shedding are associated with the progression of multiple myeloma.''' 
Proc Natl Acad Sci U S A. 2008 Jan 17;. Epub, [[PMID:18202175]]

Choi EI, Wang R, Peterson L, Letvin NL, Reimann KA. 
'''Use of an anti-CD16 antibody for in vivo depletion of natural killer cells in rhesus macaques.''' 
Immunology. 2008 Jan 12;. Epub, [[PMID:18201184]]

Margenthaler JA, Ku G, Flye MW. 
'''Interleukin-12 regulates natural killer cell-dependent Propionibacterium acnes-primed, lipopolysaccharide-induced liver injury.''' 
Hepatol Res. 2008 Feb;38(2):183-93., [[PMID:18197879]]

Hong C, Park SH. 
'''Application of natural killer T cells in antitumor immunotherapy.''' 
Crit Rev Immunol. 2007;27(6):511-25., [[PMID:18197797]]

Tu Z, Bozorgzadeh A, Pierce RH, Kurtis J, Crispe IN, Orloff MS. 
'''TLR-dependent cross talk between human Kupffer cells and NK cells.''' 
J Exp Med. 2008 Jan 14;. Epub, [[PMID:18195076]]

Kondadasula SV, Varker KA, Lesinski GB, Benson DM Jr, Lehman A, Olencki T, Monk JP, Kendra K, Carson WE 3rd. 
'''Activation of extracellular signaling regulated kinase in natural killer cells and monocytes following IL-2 stimulation in vitro and in patients undergoing IL-2 immunotherapy: analysis via dual parameter flow-cytometric assay.''' 
Cancer Immunol Immunother. 2008 Jan 10;. Epub, [[PMID:18193422]]

Watarai H, Nakagawa R, Omori-Miyake M, Dashtsoodol N, Taniguchi M. 
'''Methods for detection, isolation and culture of mouse and human invariant NKT cells.''' 
Nat Protoc. 2008;3(1):70-8., [[PMID:18193023]]

Wai LE, Fujiki M, Takeda S, Martinez OM, Krams SM. 
'''Rapamycin, but not cyclosporine or FK506, alters natural killer cell function.''' 
Transplantation. 2008 Jan 15;85(1):145-9., [[PMID:18192925]]

Alici E, Sutlu T, Bjorkstrand B, Gilljam M, Stellan B, Nahi H, Quezada HC, Gahrton G, Ljunggren HG, Dilber MS. 
'''Autologous anti-tumor activity by NK cells [[expand]]ed from myeloma patients using GMP-compliant components.''' 
Blood. 2008 Jan 11;. Epub, [[PMID:18192509]]

Gross O, Grupp C, Steinberg C, Zimmermann S, Strasser D, Hannesschlager N, Reindl W, Jonsson H, Huo H, Littman DR, Peschel C, Yokoyama WM, Krug A, Ruland J. 
'''Multiple ITAM-coupled NK cell receptors engage the Bcl10/Malt1 complex via Carma1 for NF-{kappa}B and MAPK activation to selectively control cytokine production.''' 
Blood. 2008 Jan 11;. Epub, [[PMID:18192506]]

Rogers L, Burchat S, Gage J, Hasu M, Thabet M, Wilcox L, Ramsamy TA, Whitman SC. 
'''Deficiency of Invariant V{alpha}14 Natural Killer T Cells Decreases Atherosclerosis in LDL Receptor Null Mice.''' 
Cardiovasc Res. 2008 Jan 10;. Epub, [[PMID:18192239]]

Tessarz AS, Cerwenka A. 
'''The TREM-1/DAP12 pathway.''' 
Immunol Lett. 2007 Dec 26;. Epub, [[PMID:18192027]]

Alba A, Planas R, Clemente X, Carrillo J, Ampudia R, Puertas MC, Pastor X, Tolosa E, Pujol-Borrell R, Verdaguer J, Vives-Pi M. 
'''Natural killer cells are required for accelerated type 1 diabetes driven by interferon-beta.''' 
Clin Exp Immunol. 2008 Jan 8;. Epub, [[PMID:18190608]]

Kanno H, Watabe D, Shimizu N, Sawai T. 
'''Adhesion of Epstein-Barr virus-positive natural killer cell lines to cultured endothelial cells stimulated with inflammatory cytokines.''' 
Clin Exp Immunol. 2008 Jan 8;. Epub, [[PMID:18190605]]

==January 16th, Blood CiteTrack==
Deniz, G., Erten, G., Kucuksezer, U. C., Kocacik, D., Karagiannidis, C., Aktas, E., Akdis, C. A., Akdis, M. 
'''[[Regulatory NK Cell]]s Suppress Antigen-Specific T Cell Responses''' 
[http://www.jimmunol.org/cgi/content/abstract/180/2/850?ct J Immunol 2008 180: p. 850-857], NKref0548

==January 15th, PubCrawler==
Pavlova Y, Kolesar L, Striz I, Jabor A, Slavcev A. 
'''Distribution of KIR genes in the Czech population.''' 
Int J Immunogenet. 2008 Feb;35(1):57-61., [[PMID:18186800]]

Gowda A, Roda J, Hussain RS, Ramanunni A, Joshi T, Schmidt S, Zhang X, Lehman A, Jarjoura D, Kindsvogel W, Cheney C, Caligiuri MA, Tridandapani S, Carson WE, Muthusamy N, Byrd JC. 
'''IL-21 mediates apoptosis through up-regulation of the BH3 family member BIM and enhances both direct and antibody dependent cellular cytotoxicity in primary chronic lymphocytic cells.''' 
Blood. 2008 Jan 8;. Epub, [[PMID:18182577]]

Morandi B, Bramanti P, Bonaccorsi I, Montalto E, Oliveri D, Pezzino G, Navarra M, Ferlazzo G. 
'''Role of natural killer cells in the pathogenesis and progression of multiple sclerosis.''' 
Pharmacol Res. 2007 Nov 17;. Epub, [[PMID:18182304]]

Vilches C, CastaÃ±o J, MuÃ±oz P, PeÃ±alver J. 
'''Simple genotyping of functional polymorphisms of the human immunoglobulin G receptors CD16A and CD32A: a reference cell panel.''' 
Tissue Antigens. 2008 Jan 7;. Epub, [[PMID:18179643]]

Boysen P, Gunnes G, Pende D, Valheim M, Storset AK. 
'''Natural killer cells in lymph nodes of healthy calves express CD16 and show both cytotoxic and cytokine-producing properties.''' 
Dev Comp Immunol. 2007 Dec 18;. Epub, [[PMID:18177938]]

Klimas NG, Koneru AO. 
'''Chronic fatigue syndrome: inflammation, immune function, and neuroendocrine interactions.''' 
Curr Rheumatol Rep. 2007 Dec;9(6):482-7., [[PMID:18177602]]

Zhang R, Xu J, Hong K, Yuan L, Peng H, Tang H, Ma P, Zhang Y, Xing H, Ruan Y, Shao Y. 
'''Increased NKG2A found in cytotoxic natural killer subset in HIV-1 patients with advanced clinical status.''' 
AIDS. 2007 Dec;21 Suppl 8:S9-17., [[PMID:18172398]]

==January 7th, PubCrawler==
Kondadasula SV, Roda JM, Parihar R, Yu J, Lehman A, Caligiuri MA, Tridandapani S, Burry RW, Carson WE. 
'''Co-localization of the IL-12 receptor and Fc{gamma}RIIIa to natural killer cell lipid rafts leads to activation of ERK and enhanced production of interferon-{gamma}''' 
Blood. 2008 Jan 3;. Epub, [[PMID:18174382]]

Furue H, Matsuo K, Kumimoto H, Hiraki A, Suzuki T, Yatabe Y, Komori K, Kanemitsu Y, Hirai T, Kato T, Ueda M, Ishizaki K, Tajima K. 
'''Decreased risk of colorectal cancer with the high Natural-Killer (NK)-cell activity NKG2D genotype in Japanese.''' 
Carcinogenesis. 2008 Jan 3;. Epub, [[PMID:18174257]]

Oshima T, Sonoda KH, Nakao S, Hijioka K, Taniguchi M, Ishibashi T. 
'''Protective Role for CD1d-Reactive Invariant Natural Killer T Cells in Cauterization-Induced Corneal Inflammation.''' 
Invest Ophthalmol Vis Sci. 2008 Jan;49(1):105-12., [[PMID:18172081]]

MichaÃƒÂ«lsson J, Long BR, Loo CP, Lanier LL, Spotts G, Hecht FM, Nixon DF. 
'''Immune Reconstitution of CD56(dim) NK Cells in Individuals with Primary HIV-1 Infection Treated with Interleukin-2.''' 
J Infect Dis. 2008 Jan 1;197(1):117-125., [[PMID:18171294]]

Gao B, Jeong WI, Tian Z. 
'''Liver: An organ with predominant innate immunity.''' 
Hepatology. 2007 Dec 31;. Epub, [[PMID:18167066]]

Arteel GE. 
'''Silencing a killer among us: ethanol impairs immune surveillance of activated stellate cells by natural killer cells.''' 
Gastroenterology. 2008 Jan;134(1):351-3., [[PMID:18166364]]

Jeong WI, Park O, Gao B. 
'''Abrogation of the antifibrotic effects of natural killer cells/interferon-gamma contributes to alcohol acceleration of liver fibrosis.''' 
Gastroenterology. 2008 Jan;134(1):248-58., [[PMID:18166357]]

Iwai T, Tomita Y, Shimizu I, Kajiwara T, Onzuka T, Okano S, Yasunami Y, Yoshikai Y, Nomoto K, Tominaga R. 
'''The Immunoregulatory Roles of Natural Killer T Cells in Cyclophosphamide-Induced Tolerance.''' 
Transplantation. 2007 Dec 27;84(12):1686-1695., [[PMID:18165782]]

Zein NN. 
'''Mission poorly accomplished: The protective role of natural killer cells in recurrent hepatitis C after liver transplantation.''' 
Liver Transpl. 2007 Dec 27;14(1):4-6. Epub, [[PMID:18161796]]

Boyton R. 
'''The role of natural killer T cells in lung inflammation.''' 
J Pathol. 2007 Dec 27;214(2):276-282. Epub, [[PMID:18161753]]

Ito T, Ito N, Saatoff M, Hashizume H, Fukamizu H, Nickoloff BJ, Takigawa M, Paus R. 
'''Maintenance of Hair Follicle Immune Privilege Is Linked to Prevention of NK Cell Attack.''' 
J Invest Dermatol. 2007 Dec 27;. Epub, [[PMID:18160967]]

Yabe T, Matsuo K, Hirayasu K, Kashiwase K, Kawamura-Ishii S, Tanaka H, Ogawa A, Takanashi M, Satake M, Nakajima K, Tokunaga K, Inoko H, Saji H, Ogawa S, Juji T, Sasazuki T, Kodera Y, Morishima Y. 
'''Donor killer immunoglobulin-like receptor (KIR) genotype-patient cognate KIR ligand combination and antithymocyte globulin preadministration are critical factors in outcome of HLA-C-KIR ligand-mismatched T cell-replete unrelated bone marrow transplantation.''' 
Biol Blood Marrow Transplant. 2008 Jan;14(1):75-87., [[PMID:18158964]]

Ponnampalam AP, Gargett CE, Rogers PA. 
'''Identification and hormonal regulation of a novel form of [[NKp30]] in human endometrial epithelium.''' 
Eur J Immunol. 2008 Jan;38(1):216-26., [[PMID:18157817]]

Frias AM, Porada CD, Crapnell KB, Cabral JM, Zanjani ED, Almeida-Porada G. 
'''Generation of functional natural killer and dendritic cells in a human stromal-based serum-free culture system designed for cord blood expansion.''' 
Exp Hematol. 2008 Jan;36(1):61-8., [[PMID:18155552]]

Welton AR, Gralinski LE, Spindler KR. 
'''Mouse adenovirus type 1 infection of natural killer cell-deficient mice.''' 
Virology. 2007 Dec 19;. Epub, [[PMID:18155121]]

Park JE, Wu DY, Prendes M, Lu SX, Ragupathi G, Schrantz N, Chapman PB. 
'''Fine specificity of natural killer T cells against GD3 ganglioside and identification of GM3 as an inhibitory natural killer T-cell ligand.''' 
Immunology. 2008 Jan;123(1):145-55., [[PMID:18154620]]

==Quarterly Archive of [[NK Journal Screening]] Results==
{{NK Papers Archive}}

CD56 T cell

Volker Huppert — Tue, 13 May 2008 06:02:36 GMT

Summary:

==References==
Guia, S., Cognet, C., de Beaucoudrey, L., Tessmer, M. S., Jouanguy, E., Berger, C., Filipe-Santos, O., Feinberg, J., Camcioglu, Y., Levy, J., Al Jumaah, S., Al-Hajjar, S., Stephan, J.-L., Fieschi, C., Abel, L., Brossay, L., Casanova, J.-L., Vivier, E. 
'''A role for interleukin-12/23 in the maturation of human natural killer and [[ CD56 T cell|CD56+ T cell]]s in vivo''' 
[http://bloodjournal.hematologylibrary.org/cgi/content/abstract/111/10/5008?ct Blood 2008 111: p. 5008-5016]

==Further Reading==
* [[NKT cell]]

CD27

Volker Huppert — Fri, 04 Apr 2008 15:57:35 GMT

Summary:

==References==
Vossen, M. T. M., Matmati, M., Hertoghs, K. M. L., Baars, P. A., Gent, M.-R., Leclercq, G., Hamann, J., Kuijpers, T. W., van Lier, R. A. W. 
'''[[CD27]] Defines Phenotypically and Functionally Different Human [[NK Cell Subset]]s''' 
[http://www.jimmunol.org/cgi/content/abstract/180/6/3739?ct J Immunol 2008 180: p. 3739-3745]

==Weblinks==
* [[WikiPedia:CD27]]

Cytotoxicity

Volker Huppert — Fri, 04 Apr 2008 14:51:09 GMT

Summary:

==Weblinks==
* [[WikiPedia:Cytotoxicity]]

NK cell products

Volker Huppert — Fri, 21 Mar 2008 19:18:34 GMT

Summary:

==NK cell isolation==
===Human===
* [http://www.miltenyibiotec.com/en/NN_56_NK_cells.aspx MACS Separation of human NK cells]
===Murine===
* [http://www.miltenyibiotec.com/en/NN_90_NK_cells.aspx MACS Separation of mouse NK cells]

==NK cell analysis==
===Flow Cytometry===
* [http://www.coulter.com/eCatalog/Catalog/Flow_Cytometry/Discipline/NK_Cells Beckman Coulter]
* [http://www.miltenyibiotec.com/download/background_information/1005/NK_productlist.pdf Miltenyi Biotec NK cell product list]
===Gene and Transkript Analysis===
* [http://www.miltenyibiotec.com/en/PG_606_619_KIR_Typing_Kit.aspx KIR Typing]

==NK cell culture==

HLA-E

Volker Huppert — Sun, 09 Mar 2008 04:19:25 GMT

Summary:

==References==
Mazzarino P, Pietra G, Vacca P, Falco M, Colau D, Coulie P, Moretta L, Mingari MC. 
'''Identification of effector-memory CMV-specific T lymphocytes that kill [[CMV]]-infected target cells in an [[HLA-E]]-restricted fashion.''' 
Eur J Immunol. 2005 Nov;35(11):3240-7., [[PMID:16224817]]

CMV

Volker Huppert — Sun, 09 Mar 2008 04:19:07 GMT

Summary:

HLA

Volker Huppert — Sun, 09 Mar 2008 01:45:14 GMT

Summary:

==Ligands==
* [[KIR]]s
* Antibodies

==Weblinks==
* [[WikiPedia:Human_leukocyte_antigen]]
* [http://141.52.175.50:8080/yacysearch.html?display=0&search=HLA search for HLA @ sciencenet.fzk.de]

Multiple Myeloma

Volker Huppert — Thu, 28 Feb 2008 21:53:00 GMT

Summary:

==Introduction==
[[Multiple myeloma]] (also known as [[MM]], [[myeloma]], [[plasma cell myeloma]], or as [[Kahler's disease]] ([[WikiPedia:Otto Kahler]]) is a hematological malignancy (malignant neoplasm), a type of cancer of plasma cells. Myeloma is regarded as incurable, but remissions may be induced with glucocorticoid steroids, chemotherapy, thalidomide and [[stem cell transplant]]s. [[NK cell therapy]] of [[MM]] has been evaluated, but success was limited. MM accounts for 20% of deaths caused by hematological malignancies (Alici 2008, Kuehl 2002).

The immune system of MM patients is significantly impaired, MM patients are susceptible to infections (Zinneman 1954). MM cells are resistant to lysis by resting and IL-2 activated autologous NK cells, (in part) due to impaired NK cytotoxicity, increased levels of soluble IL-2 receptors and decreased activating NK cell receptor expression (Uchida, Bianchi, OgmundsdÃ³ttir, Nielsen, Fauriat).

Alici et al. (2008) show, that [[NK cell]]s from [[MM]] patients can be expanded more than 500 fold within 20 days. Expanded NK cells had an increased expression of activating receptors (including [[CD16]], [[NCR]]s and [[NKG2D]]) and showed increased cytotoxicity against both [[K562]] and autologous [[Multiple Myeloma]] cells but no significant cytotoxicity towards non-MM cells.

Several activating receptors contribute synergistically to NK cytotoxicity towards MM cells (Alici 2008, Bryceson 2006), resulting in 30% degranulation of NK cells in co-culture with MM cells. Thus the impaired NK cell function of MM patients can be overcome by long term culture under appropriate conditions.

==References==
Alici E, Sutlu T, Bjorkstrand B, Gilljam M, Stellan B, Nahi H, Quezada HC, Gahrton G, Ljunggren HG, Dilber MS. 
'''Autologous anti-tumor activity by [[NK cell]]s [[expand]]ed from [[myeloma]] patients using GMP-compliant components.''' 
Blood. 2008 Jan 11;. Epub, [[PMID:18192509]]

Kuehl WM, Bergsagel PL. 
'''[[Multiple myeloma]]: evolving genetic events and host interactions.''' 
Nat Rev Cancer. 2002 Mar;2(3):175-87. Review., [[PMID:11990854]]

Bryceson YT, March ME, Ljunggren HG, Long EO. 
'''Synergy among receptors on resting [[NK cell]]s for the [[activation]] of natural cytotoxicity and cytokine secretion.''' 
Blood. 2006 Jan 1;107(1):159-66. Epub 2005 Sep 8., [[PMID:16150947]] [[http://bloodjournal.hematologylibrary.org/cgi/content/full/107/1/159 Free Fulltext]]

Uchida A, Yagita M, Sugiyama H, Hoshino T, Moore M. 
'''Strong natural killer (NK) cell activity in bone marrow of myeloma patients: accelerated maturation of bone marrow NK cells and their interaction with other bone marrow cells.''' 
Int J Cancer. 1984 Sep 15;34(3):375-81., [[PMID:6592156]]

Bianchi A, OmedÃ© P, Attisano C, Camponi A, Dianzani U, Boccadoro M, Pileri A, Massaia M. 
'''Phenotypic and functional analysis of peripheral blood lymphocytes during interferon-alpha 2b therapy in multiple myeloma patients with low tumor mass.''' 
Haematologica. 1991 Sep-Oct;76(5):383-8., [[PMID:1806441]]

OgmundsdÃ³ttir HM. 
'''Natural killer cell activity in patients with multiple myeloma.''' 
Cancer Detect Prev. 1988;12(1-6):133-43., [[PMID:2460235]]

Nielsen H, Nielsen HJ, Tvede N, Klarlund K, Mansa B, Moesgaard F, Drivsholm A. 
'''Immune dysfunction in [[multiple myeloma]]. Reduced natural killer cell activity and increased levels of soluble [[interleukin-2]] receptors.''' 
APMIS. 1991 Apr;99(4):340-6., [[PMID:2036217]]

Fauriat C, Mallet F, Olive D, Costello RT. 
'''Impaired activating receptor expression pattern in natural killer cells from patients with [[multiple myeloma]].''' 
Leukemia. 2006 Apr;20(4):732-3. [[PMID:16437151]]

Zinneman HH, Hall WH. 
'''Recurrent pneumonia in multiple myeloma and some observations on immunologic response.''' 
Ann Intern Med. 1954 Dec;41(6):1152-63., [[PMID:13218500]]

==Weblinks==
* [[WikiPedia:Multiple_Myeloma]]
* [http://www.myeloma.org.uk Myeloma UK]
* [http://www.myeloma.org International Myeloma Foundation]
* [http://www.multiplemyeloma.org Multiple Myeloma Research Foundation]
* [http://www.mmsupport.net/ MM Support Network]
* [http://www.myeloma-euronet.org Myeloma Euronet] - European Network of Myeloma Patient Groups
* [http://www.leukemia-lymphoma.org/all_page?item_id=7032 The Leukemia & Lymphoma Society's Myeloma Page]
* [http://www.mayoclinic.org/multiple-myeloma/ Overview at Mayo Clinic]

Feeder Cell

Volker Huppert — Thu, 28 Feb 2008 19:28:56 GMT

Summary:

[[Feeder Cell]]s are frequently used in [[NK Cell Expansion]] Protocols. They provide either soluble factors such as cytokines or receptor mediated triggering, frequently both. Soluble factors and/or receptor triggering promote growth of NK cells.
Feeder Cells are usually irradiated before co-culture with NK cells to avoid overgrowth of the feeders. Alternatively to cell cycle arrest by irradation feeder cells can also be treated with Mytomycin.

Frequently used Feeder Cells:
* [[K562]]
* [[RPMI8866]]
* [[HFWT]]
* [[K562-mb15-41BBL]]
* (mixed) allogeneic PBMC

NK Papers Q4 2007

Volker Huppert — Thu, 21 Feb 2008 23:01:43 GMT

Summary:

==December 28th, PubCrawler==
Chuang YH, Lian ZX, Yang GX, Shu SA, Moritoki Y, Ridgway WM, Ansari AA, Kronenberg M, Flavell RA, Gao B, Gershwin ME. 
'''Natural killer T cells exacerbate liver injury in a transforming growth factor beta receptor II dominant-negative mouse model of primary biliary cirrhosis.''' 
Hepatology. 2007 Dec 20;. Epub, [[PMID:18098320]]

Harada H, Murakami T, Tea SS, Takeuchi A, Koga T, Okada S, Suico MA, Shuto T, Kai H. 
'''Heat shock suppresses human NK cell cytotoxicity via regulation of perforin.''' 
Int J Hyperthermia. 2007 Dec;23(8):657-65., [[PMID:18097852]]

Fausther-Bovendo H, Wauquier N, Cherfils-Vicini J, Cremer I, DebrÃƒÂ© P, Vieillard V. 
'''NKG2C is a major triggering receptor involved in the Vdelta1 T cell-mediated cytotoxicity against HIV-infected CD4 T cells.''' 
AIDS. 2008 Jan 11;22(2):217-226., [[PMID:18097224]]

Kobayashi A, Hara H, Ohashi M, Nishimoto T, Yoshida K, Ohkohchi N, Yoshida T, Aoki K. 
'''Allogeneic MHC gene transfer enhances an effective antitumor immunity in the early period of autologous hematopoietic stem cell transplantation.''' 
Clin Cancer Res. 2007 Dec 15;13(24):7469-79., [[PMID:18094431]]

Walsh KB, Lodoen MB, Edwards RA, Lanier LL, Lane TE. 
'''Evidence for differential roles for NKG2D signaling in innate host defense against coronavirus-induced neurological and liver disease.''' 
J Virol. 2007 Dec 19;. Epub, [[PMID:18094157]]

Gardiner CM. 
'''Killer cell immunoglobulin-like receptors on NK cells: the how, where and why.''' 
Int J Immunogenet. 2007 Dec 18;. Epub, [[PMID:18093180]]

Byrd A, Hoffmann SC, Jarahian M, Momburg F, Watzl C. 
'''Expression Analysis of the Ligands for the Natural Killer Cell Receptors NKp30 and NKp44.''' 
PLoS ONE. 2007 Dec 19;2(12):e1339., [[PMID:18092004]]

Kunert K, Seiler M, Mashreghi MF, Klippert K, SchÃƒÂ¶nemann C, Neumann K, Pratschke J, Reinke P, Volk HD, Kotsch K. 
'''KIR/HLA Ligand Incompatibility in Kidney Transplantation.''' 
Transplantation. 2007 Dec 15;84(11):1527-1533., [[PMID:18091530]]

Barker E, Martinson J, Brooks C, Landay A, Deeks S. 
'''Dysfunctional natural killer cells, in vivo, are governed by HIV viremia regardless of whether the infected individual is on antiretroviral therapy.''' 
AIDS. 2007 Nov 12;21(17):2363-5., [[PMID:18090295]]

Mela CM, Steel A, Lindsay J, Gazzard BG, Gotch FM, Goodier MR. 
'''Depletion of natural killer cells in the colonic lamina propria of viraemic HIV-1-infected individuals.''' 
AIDS. 2007 Oct 18;21(16):2177-82., [[PMID:18090044]]

Varchetta S, Gibelli N, Oliviero B, Nardini E, Gennari R, Gatti G, Silva LS, Villani L, Tagliabue E, MÃƒÂ©nard S, Costa A, Fagnoni FF. 
'''Elements related to heterogeneity of antibody-dependent cell cytotoxicity in patients under trastuzumab therapy for primary operable breast cancer overexpressing Her2.''' 
Cancer Res. 2007 Dec 15;67(24):11991-9., [[PMID:18089830]]

Zhu FM, Jiang K, LÃ¼ QF, Zhang W, He J, Xu XG, Yan LX. 
'''Analysis of Natural Killer Cell Immunoglobulin-like Receptor Gene Family in HLA-identical Sibling.''' 
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2007 Dec;15(6):1276-80. Chinese., [[PMID:18088483]]

Lee IF, Qin H, Priatel JJ, Tan R. 
'''Critical role for IFN-gamma in natural killer cell-mediated protection from diabetes.''' 
Eur J Immunol. 2007 Dec 12;. Epub, [[PMID:18085661]]

Sullivan LC, Clements CS, Beddoe T, Johnson D, Hoare HL, Lin J, Huyton T, Hopkins EJ, Reid HH, Wilce MC, Kabat J, Borrego F, Coligan JE, Rossjohn J, Brooks AG. 
'''The Heterodimeric Assembly of the CD94-NKG2 Receptor Family and Implications for Human Leukocyte Antigen-E Recognition.''' 
Immunity. 2007 Dec;27(6):900-11., [[PMID:18083576]]

KnÃ¶fler M, Simmons DG, Lash GE, Harris LK, Armant DR. 
'''Regulation of Trophoblast Invasion-A Workshop Report.''' 
Placenta. 2007 Dec 14;. Epub, [[PMID:18083227]]

==December 16th, PubCrawler==
Gober MD, Fishelevich R, Zhao Y, Unutmaz D, Gaspari AA. 
'''Human Natural Killer T Cells Infiltrate into the Skin at Elicitation Sites of Allergic Contact Dermatitis.''' 
J Invest Dermatol. 2007 Dec 13;. Epub, [[PMID:18079745]]

Lang GA, Devera TS, Lang ML. 
'''Requirement for CD1d expression by B cells to stimulate NKT cell-enhanced antibody production.''' 
Blood. 2007 Dec 12;. Epub, [[PMID:18077787]]

Lengacher CA, Bennett MP, Gonzalez L, Gilvary D, Cox CE, Cantor A, Jacobsen PB, Yang C, Djeu J. 
'''Immune responses to guided imagery during breast cancer treatment.''' 
Biol Res Nurs. 2008 Jan;9(3):205-14., [[PMID:18077773]]

Ho JW, Hershkovitz O, Peiris M, Zilka A, Bar-Ilan A, Nal B, Chu K, Kudelko M, Kam YW, Achdout H, Mandelboim M, Altmeyer R, Mandelboim O, Bruzzone R, Porgador A. 
'''H5-type Influenza Hemagglutinin is Functionally Recognized by the Natural Killer Activating Receptor, [[NKp44]].''' 
J Virol. 2007 Dec 12;. Epub, [[PMID:18077718]]

Salio M, Speak AO, Shepherd D, Polzella P, Illarionov PA, Veerapen N, Besra GS, Platt FM, Cerundolo V. 
'''Modulation of human natural killer T cell ligands on TLR-mediated antigen-presenting cell activation.''' 
Proc Natl Acad Sci U S A. 2007 Dec 11;. Epub, [[PMID:18077358]]

van den Heuvel MJ, Hatta K, Peralta CG, Han VK, Clark DA. 
'''CD56(+) Cells are Recruited to the Uterus in Two Waves: at Ovulation and During the First 2 Weeks after Missed Menses.''' 
Am J Reprod Immunol. 2007 Nov 25;. Epub, [[PMID:18076635]]

Behar G, SibÃ©ril S, Groulet A, Chames P, PugniÃ¨re M, Boix C, SautÃ¨s-Fridman C, Teillaud JL, Baty D. 
'''Isolation and characterization of anti-Fc{gamma}RIII (CD16) llama single-domain antibodies that activate natural killer cells.''' 
Protein Eng Des Sel. 2007 Dec 11;. Epub, [[PMID:18073223]]

Wilkinson GW, Tomasec P, Stanton RJ, Armstrong M, Prod'homme V, Aicheler R, McSharry BP, Rickards CR, Cochrane D, Llewellyn-Lacey S, Wang EC, Griffin CA, Davison AJ. 
'''Modulation of natural killer cells by human cytomegalovirus.''' 
J Clin Virol. 2007 Dec 7;. Epub, [[PMID:18069056]]

Li W, Lidebjer C, Yuan XM, Szymanowski A, Backteman K, Ernerudh J, Leanderson P, Nilsson L, Swahn E, Jonasson L. 
'''NK cell apoptosis in coronary artery disease Relation to oxidative stress.''' 
Atherosclerosis. 2007 Dec 7;. Epub, [[PMID:18068708]]

Li D, Chen N, McMichael AJ, Screaton GR, Xu XN. 
'''Generation and characterisation of CD1d tetramer produced by a lentiviral expression system.''' 
J Immunol Methods. 2007 Nov 26;. Epub, [[PMID:18068183]]

Kusakabe K, Naka M, Ito Y, Eid N, Otsuki Y. 
'''Regulation of natural-killer cell cytotoxicity and enhancement of complement factors in the spontaneously aborted mouse placenta.''' 
Fertil Steril. 2007 Dec 6;., [[PMID:18068164]]

Yoon TJ, Kim TJ, Lee H, Shin KS, Yun YP, Moon WK, Kim DW, Lee KH. 
'''Anti-tumor metastatic activity of beta-glucan purified from mutated Saccharomyces cerevisiae.''' 
Int Immunopharmacol. 2008 Jan;8(1):36-42., [[PMID:18068098]]

Barral DC, Brenner MB. 
'''CD1 antigen presentation: how it works.''' 
Nat Rev Immunol. 2007 Dec;7(12):929-41., [[PMID:18037897]]

also see latest [http://www.nkcells.info/BioMail/2007_12_15_biomail_01.htm BioMail addition].

==December 14th, PubCrawler==
Li Q, Kobayashi M, Kawada T. 
'''DDVP markedly decreases the expression of granzyme B and granzyme 3/K in human NK cells.''' 
Toxicology. 2007 Oct 26;. Epub, [[PMID:18063463]]

Airas L, Saraste M, Rinta S, Elovaara I, Huang YH, Wiendl H. 
'''Immunoregulatory factors in multiple sclerosis patients during and after pregnancy: relevance of natural killer cells.''' 
Clin Exp Immunol. 2007 Dec 6;. Epub, [[PMID:18062798]]

Scordamaglia F, Balsamo M, Scordamaglia A, Moretta A, Mingari MC, Canonica GW, Moretta L, Vitale M. 
'''Perturbations of natural killer cell regulatory functions in respiratory allergic diseases.''' 
J Allergy Clin Immunol. 2007 Nov 30;. Epub, [[PMID:18061653]]

Karimi K, Boudreau JE, Fraser K, Liu H, Delanghe J, Gauldie J, Xing Z, Bramson JL, Wan Y. 
'''Enhanced Antitumor Immunity Elicited by Dendritic Cell Vaccines Is a Result of Their Ability to Engage Both CTL and IFNgamma-producing NK Cells.''' 
Mol Ther. 2007 Dec 4;. Epub, [[PMID:18059374]]

Kitajima M, Abe T, Miyano-Kurosaki N, Taniguchi M, Nakayama T, Takaku H. 
'''Induction of Natural Killer Cell-dependent Antitumor Immunity by the Autographa californica Multiple Nuclear Polyhedrosis Virus.''' 
Mol Ther. 2007 Dec 4;. Epub, [[PMID:18059370]]

Davis ID, Skak K, Smyth MJ, Kristjansen PE, Miller DM, Sivakumar PV. 
'''Interleukin-21 signaling: functions in cancer and autoimmunity.''' 
Clin Cancer Res. 2007 Dec 1;13(23):6926-32., [[PMID:18056166]]

Bergamaschi C, Rosati M, Jalah R, Valentin A, Kulkarni V, Alicea C, Zhang GM, Patel V, Felber BK, Pavlakis GN. 
'''Intracellular interaction of IL-15 with its receptor alpha during production leads to mutual stabilization and increased bioactivity.''' 
J Biol Chem. 2007 Nov 30;. Epub, [[PMID:18055460]]

Pogge von Strandmann E, Simhadri VR, von Tresckow B, Sasse S, Reiners KS, Hansen HP, Rothe A, BÃƒÂ¶ll B, Simhadri VL, Borchmann P, McKinnon PJ, Hallek M, Engert A 
'''Human Leukocyte Antigen-B-Associated Transcript 3 Is Released from Tumor Cells and Engages the NKp30 Receptor on Natural Killer Cells.''' 
Immunity. 2007 Dec 3;. Epub, [[PMID:18055229]]

de Rham C, Ferrari-Lacraz S, Jendly S, Schneiter G, Dayer JM, Villard J. 
'''The pro-inflammatory cytokines IL-2, IL-15 and IL-21 modulate the repertoire of mature human natural killer cell receptors.''' 
Arthritis Res Ther. 2007 Dec 3;9(6):R125. Epub, [[PMID:18053164]]

Takahashi T, Strober S. 
'''Natural killer T cells and innate immune B cells from lupus-prone NZB/W mice interact to generate IgM and IgG autoantibodies.''' 
Eur J Immunol. 2007 Nov 29;. Epub, [[PMID:18050273]]

Saboia-Dantas CJ, Coutrin de Toledo LF, Siqueira JF Jr, Sampaio-Filho HR, Carvalho JJ, Pereira MJ. 
'''Natural killer cells and alterations in collagen density: signs of periradicular herpesvirus infection?''' 
Clin Oral Investig. 2007 Nov 29;. Epub, [[PMID:18046588]]

Spreu J, Kienle EC, Schrage B, Steinle A. 
'''[[CLEC2A]]: a novel, alternatively spliced and skin-associated member of the NKC-encoded [[AICL]]-CD69-LLT1 family.''' 
Immunogenetics. 2007 Nov 29;. Epub, [[PMID:18046548]]

Verheyden S, Demanet C. 
'''NK cell receptors and their ligands in leukemia.''' 
Leukemia. 2007 Nov 29;. Epub, [[PMID:18046448]]

Kalita JK, Chandrashekar K, Hans R, Selvam P. 
'''Computational modelling and simulation of the immune system.''' 
Int J Bioinform Res Appl. 2006;2(1):63-88., [[PMID:18048154]]

Marcet-Palacios M, Odemuyiwa SO, Coughlin J, Garofoli D, Ewen C, Davidson C, Ghaffari M, Kane KP, Lacy P, Logan MR, Befus AD, Bleackley RC, Moqbel R. 
'''Vesicle-associated membrane protein 7 (VAMP-7) is essential for target cell killing in a natural killer cell line.''' 
Biochem Biophys Res Commun. 2007 Nov 24;. Epub, [[PMID:18042464]]

Verneris MR, Wagner JE. 
'''Recent developments in cell-based immune therapy for neuroblastoma.''' 
J Neuroimmune Pharmacol. 2007 Jun;2(2):134-9., [[PMID:18040838]]

Manaster I, Mandelboim O. 
'''The unique properties of human NK cells in the uterine mucosa.''' 
Placenta. 2007 Nov 24;. Epub, [[PMID:18039547]]

Guruvayoorappan C, Kuttan G. 
'''Amentoflavone, a biflavonoid from Biophytum sensitivum augments lymphocyte proliferation, natural killer cell and antibody dependent cellular cytotoxicity through enhanced production of IL-2 and IFN-gamma and restrains serum sialic acid and gamma glutamyl transpeptidase production in tumor - bearing animals.''' 
J Exp Ther Oncol. 2007;6(4):285-95., [[PMID:18038762]]

Hattori T, Kokura S, Okuda T, Okayama T, Takagi T, Handa O, Naito Y, Yoshida N, Yoshikawa T. 
'''Antitumor effect of whole body hyperthermia with alpha-galactosylceramide in a subcutaneous tumor model of colon cancer.''' 
Int J Hyperthermia. 2007 Nov;23(7):591-8., [[PMID:18038289]]

Smetak M, Kimmel B, Birkmann J, Schaefer-Eckart K, Einsele H, Wilhelm M, Kunzmann V. 
'''Clinical-scale single-step CD4(+) and CD8(+) cell depletion for donor innate lymphocyte infusion (DILI).''' 
Bone Marrow Transplant. 2007 Nov 26;. Epub, [[PMID:18037935]]

Alici E, Konstantinidis KV, Sutlu T, Aints A, Gahrton G, Ljunggren HG, Dilber MS. 
'''Anti-myeloma activity of endogenous and adoptively transferred activated natural killer cells in experimental multiple myeloma model.''' 
Exp Hematol. 2007 Dec;35(12):1839-46., [[PMID:18036444]]

==November 26th, PubCrawler==
Kock H, Fischer U. 
'''A novel immunoglobulin-like transcript from rainbow trout with two Ig-like domains and two isoforms.''' 
Mol Immunol. 2007 Nov 20;. Epub, [[PMID:18035417]]

Salaun B, Romero P, Lebecque S. 
'''Toll-like receptors' two-edged sword: when immunity meets apoptosis.''' 
Eur J Immunol. 2007 Nov 22;. Epub, [[PMID:18034428]]

Nachmias B, Mizrahi S, Elmalech M, Lazar I, Ashhab Y, Gazit R, Markel G, Ben-Yehuda D, Mandelboim O. 
'''Manipulation of NK cytotoxicity by the IAP family member Livin.''' 
Eur J Immunol. 2007 Nov 22;. Epub, [[PMID:18034418]]

Nguyen S, Kuentz M, Vernant JP, Dhedin N, Bories D, DebrÃ© P, Vieillard V. 
'''Involvement of mature donor T cells in the NK cell reconstitution after haploidentical hematopoietic stem-cell transplantation.''' 
Leukemia. 2007 Nov 22;. Epub, [[PMID:18033316]]

Moretta L. 
'''NK cell-mediated immune response against cancer.''' 
Surg Oncol. 2007 Nov 19;. Epub, [[PMID:18032029]]

Griewank K, Borowski C, Rietdijk S, Wang N, Julien A, Wei DG, Mamchak AA, Terhorst C, Bendelac A. 
'''Homotypic interactions mediated by slamf1 and slamf6 receptors control NKT cell lineage development.''' 
Immunity. 2007 Nov;27(5):751-62., [[PMID:18031695]]

Mandelli F, Capria S, Vignetti M, Meloni G. 
'''Use of interleukin-2 in the management of haematological malignancies: focus on minimal residual disease.''' 
BioDrugs. 1999 Jul;12(1):43-53., [[PMID:1803116]]

Vacher-Coponat H, Brunet C, Lyonnet L, Bonnet E, Loundou A, Sampol J, Moal V, Dussol B, Brunet P, Berland Y, Dignat-George F, Paul P. 
'''Natural killer cell alterations correlate with loss of renal function and dialysis duration in uraemic patients.''' 
Nephrol Dial Transplant. 2007 Nov 20;. Epub, [[PMID:18029366]]

Vahlne G, Becker S, Brodin P, Johansson MH. 
'''IFN-gamma Production and Degranulation are Differentially Regulated in Response to Stimulation in Murine Natural Killer Cells.''' 
Scand J Immunol. 2007 Nov 19;. Epub, [[PMID:18028287]]

Persson CM, Assarsson E, Vahlne G, Brodin P, Chambers BJ. 
'''Critical Role of Qa1(b) in the Protection of Mature Dendritic Cells from NK Cell-Mediated Killing.''' 
Scand J Immunol. 2007 Nov 19;. Epub, [[PMID:18028286]]

Damaj BB, Becerra CB, Esber HJ, Wen Y, Maghazachi AA. 
'''Functional expression of h4 histamine receptor in human natural killer cells, monocytes, and dendritic cells.''' 
J Immunol. 2007 Dec 1;179(11):7907-15., [[PMID:18025238]]

Alter G, Martin MP, Teigen N, Carr WH, Suscovich TJ, Schneidewind A, Streeck H, Waring M, Meier A, Brander C, Lifson JD, Allen TM, Carrington M, Altfeld M. 
'''Differential natural killer cell mediated inhibition of HIV-1 replication based on distinct KIR/HLA subtypes.''' 
J Exp Med. 2007 Nov 19;. Epub, [[PMID:18025129]]

Morita I, Kizuka Y, Kakuda S, Oka S. 
'''Expression and function of the HNK-1 carbohydrate.''' 
J Biochem (Tokyo). 2007 Nov 20;. Epub, [[PMID:18024472]]

Emoto M, Yoshizawa I, Emoto Y, Takahashi Y, Hurwitz R, Miamoto M, Kaufmann SH. 
'''Reversible NK1.1 surface expression on invariant liver natural killer T cells during Listeria monocytogenes infection.''' 
Microbes Infect. 2007 Oct 7;. Epub, [[PMID:18024119]]

Zhang Y, Zhao A, Wang X, Shi G, Jin H, Lin Q. 
'''Expressions of natural cytotoxicity receptors and NKG2D on decidual natural killer cells in patients having spontaneous abortions.''' 
Fertil Steril. 2007 Nov 17;. Epub, [[PMID:18023431]]

Melum E, Karlsen TH, Schrumpf E, Bergquist A, Thorsby E, Boberg KM, Lie BA. 
'''Cholangiocarcinoma in primary sclerosing cholangitis is associated with NKG2D polymorphisms.''' 
Hepatology. 2007 Nov 19;. Epub, [[PMID:18023027]]

Reier A, Mitsuyasu RT. 
'''Use of interleukin-2 in immunotherapy of human immunodeficiency virus infection.''' 
BioDrugs. 1998 Sep;10(3):215-25., [[PMID:18020597]]

Chueh C, Kahan BD. 
'''Altered major histocompatibility complex proteins and peptides for the induction of tolerance after organ transplantation.''' 
BioDrugs. 1998 May;9(5):397-417., [[PMID:18020574]]

Chen W, Xia C, Wang J, Thapa P, Li Y, Nadas J, Zhang W, Zhou D, Wang PG. 
'''Synthesis and Structure-Activity Relationship Study of Isoglobotrihexosylceramide Analogues.''' 
J Org Chem. 2007 Nov 17;. Epub, [[PMID:18020363]]

==November 19th, Blood Table of Contents==
Shengqiao Li, Yehong Yan, Yuan Lin, Dominique M. Bullens, Omer Rutgeerts, Jozef Goebels, Constant Segers, Louis Boon, Ahmad Kasran, Rita De Vos, Christiane Dewolf-Peeters, Mark Waer, and An D. Billiau 
'''Rapidly induced, T-cell independent xenoantibody production is mediated by marginal zone B cells and requires help from NK cells''' 
[http://bloodjournal.hematologylibrary.org/cgi/content/abstract/110/12/3926?etoc Blood 2007;110 3926-3935]

==November 18th, PubCrawler==
Hershkovitz O, Jarahian M, Zilka A, Bar-Ilan A, Landau G, Jivov S, Tekoah Y, Glicklis R, Gallagher JT, Hoffmann SC, Zer H, Mandelboim O, Watzl C, Momburg F, Porgador A. 
'''Altered Glycosylation of Recombinant [[NKp30]] Hampers Binding to Heparan Sulfate: a Lesson for the Use of Recombinant Immuno-Receptors as an Immunological Tool.''' 
Glycobiology. 2007 Nov 15;. Epub, [[PMID:18006589]]

Yasuo T, Kitaya K, Yamaguchi T, Fushiki S, Honjo H. 
'''Possible role of hematopoietic CD44/chondroitin sulfate interaction in extravasation of peripheral blood CD16(-) natural killer cells into human endometrium.''' 
J Reprod Immunol. 2007 Nov 13;. Epub, [[PMID:18006074]]

Morita M, Fujino M, Li XK, Kimura H, Nakayama T, Taniguchi M, Sugioka A. 
'''Spontaneous tolerance involving natural killer T cells after hepatic grafting in mice.''' 
Transpl Immunol. 2007 Nov;18(2):142-145., [[PMID:18005859]]

Penack O, Fischer L, Gentilini C, Nogai A, Muessig A, Rieger K, Ganepola S, Thiel E, Uharek L. 
'''The type of ATG matters - Natural killer cells are influenced differentially by Thymoglobulin, Lymphoglobulin and ATG-Fresenius.''' 
Transpl Immunol. 2007 Nov;18(2):85-87., [[PMID:18005849]]

Skak K, Frederiksen KS, Lundsgaard D. 
'''Interleukin-21 activates human natural killer cells and modulates their surface receptor expression.''' 
Immunology. 2007 Nov 14;. Epub, [[PMID:18005035]]

Iizuka A, Ikarashi Y, Yoshida M, Heike Y, Takeda K, Quinn G, Wakasugi H, Kitagawa M, Takaue Y. 
'''Interleukin (IL)-4 promotes T helper type 2-biased natural killer T (NKT) cell expansion, which is regulated by NKT cell-derived interferon-gamma and IL-4.''' 
Immunology. 2007 Nov 14;. Epub, [[PMID:18005033]]

Kao IT, Yao CL, Kong ZL, Wu ML, Chuang TL, Hwang SM. 
'''Generation of Natural Killer Cells from Serum-Free, Expanded Human Umbilical Cord Blood CD34(+) Cells.''' 
Stem Cells Dev. 2007 Nov 14;. Epub, [[PMID:17999637]]

Kim HM, Lim J, Yoon YD, Ahn JM, Kang JS, Lee K, Park SK, Jeong YJ, Kim JM, Han G, Yang KH, Kim YJ, Kim Y, Han SB. 
'''Anti-tumor activity of ex vivo expanded cytokine-induced killer cells against human hepatocellular carcinoma.''' 
Int Immunopharmacol. 2007 Dec 15;7(13):1793-801., [[PMID:17996690]]

Hao S, Zhao J, Zhou J, Zhao S, Hu Y, Hou Y. 
'''Modulation of 17beta-estradiol on the number and cytotoxicity of NK cells in vivo related to MCM and activating receptors.''' 
Int Immunopharmacol. 2007 Dec 15;7(13):1765-75., [[PMID:17996687]]

Reddy N, Hernandez-Ilizaliturri FJ, Deeb G, Roth M, Vaughn M, Knight J, Wallace P, Czuczman MS. 
'''Immunomodulatory drugs stimulate natural killer-cell function, alter cytokine production by dendritic cells, and inhibit angiogenesis enhancing the anti-tumour activity of rituximab in vivo.''' 
Br J Haematol. 2007 Nov 11;. Epub, [[PMID:17995965]]

Diermayr S, Himmelreich H, Durovic B, Mathys-Schneeberger A, Siegler U, Langenkamp U, Hofsteenge J, Gratwohl A, Tichelli A, Paluszewska M, Wiktor-Jedrzejczak W, Kalberer CP, Wodnar-Filipowicz A. 
'''[[NKG2D]] ligand expression in AML increases in response to HDAC inhibitor valproic acid and contributes to allorecognition by NK cell lines with single [[KIR]]-HLA-class I specificities.''' 
Blood. 2007 Nov 9;. Epub, [[PMID:17993609]]

==November 11th, PubCrawler==
Vaknin I, Blinder L, Wang L, Gazit R, Shapira E, Genina O, Pines M, Pikarsky E, Baniyash M. 
'''A common pathway mediated through Toll-like receptors leads to T and natural killer cell immunosuppression.''' 
Blood. 2007 Nov 8;. Epub, [[PMID:17991807]]

Vilarinho S, Ogasawara K, Nishimura S, Lanier LL, Baron JL. 
'''Blockade of NKG2D on NKT cells prevents hepatitis and the acute immune response to hepatitis B virus.''' 
Proc Natl Acad Sci U S A. 2007 Nov 8;. Epub, [[PMID:17991774]]

El Haj M, Ya'acov AB, Lalazar G, Ilan Y. 
'''Potential role of NKT regulatory cell ligands for the treatment of immune mediated colitis.''' 
World J Gastroenterol. 2007 Nov 28;13(44):5799-804., [[PMID:17990345]]

Kreijveld E, van der Meer A, Tijssen HJ, Hilbrands LB, Joosten I. 
'''KIR gene and KIR ligand analysis to predict graft rejection after renal transplantation.''' 
Transplantation. 2007 Oct 27;84(8):1045-51., [[PMID:17989611]]]

Latour S. 
'''Natural killer T cells and X-linked lymphoproliferative syndrome.''' 
Curr Opin Allergy Clin Immunol. 2007 Dec;7(6):510-4., [[PMID:17989527]]

Dalbeth N, Callan MF. 
'''Phenotypic and functional analysis of synovial natural killer cells.''' 
Methods Mol Med. 2007;136:149-63., [[PMID:17983146]]

Penack O, Fischer L, Stroux A, Gentilini C, Nogai A, Muessig A, Rieger K, Ganepola S, Herr W, Meyer RG, Thiel E, Uharek L. 
'''Serotherapy with thymoglobulin and alemtuzumab differentially influences frequency and function of natural killer cells after allogeneic stem cell transplantation.''' 
Bone Marrow Transplant. 2007 Nov 5;., [[PMID:17982494]]

Claus M, Meinke S, Bhat R, Watzl C. 
'''Regulation of NK cell activity by 2B4, NTB-A and CRACC.''' 
Front Biosci. 2008 Jan 1;13:956-65., [[PMID:17981603]]

Fujii S, Shimizu K, Hemmi H, Steinman RM. 
'''Innate Valpha14(+) natural killer T cells mature dendritic cells, leading to strong adaptive immunity.''' 
Immunol Rev. 2007 Dec;220(1):183-98., [[PMID:17979847]]

Gregoire C, Chasson L, Luci C, Tomasello E, Geissmann F, Vivier E, Walzer T. 
'''The trafficking of natural killer cells.''' 
Immunol Rev. 2007 Dec;220(1):169-82., [[PMID:17979846]]

Li Q, Morimoto K, Nakadai A, Inagaki H, Katsumata M, Shimizu T, Hirata Y, Hirata K, Suzuki H, Miyazaki Y, Kagawa T, Koyama Y, Ohira T, Takayama N, Krensky AM, Kawada T. 
'''Forest bathing enhances human natural killer activity and expression of anti-cancer proteins.''' 
Int J Immunopathol Pharmacol. 2007 Apr-Jun;20(2 Suppl 2):1-8., [[PMID:17903349]]

==November 9th, Meltwater News==
Wrobel P, Shojaei H, Schittek B, Gieseler F, Wollenberg B, Kalthoff H, Kabelitz D, Wesch D. 
'''Lysis of a broad range of epithelial tumour cells by human [[gamma delta T cell]]s: involvement of [[NKG2D]] ligands and T-cell receptor- versus [[NKG2D]]-dependent recognition.''' 
Scand J Immunol. 2007 Aug-Sep;66(2-3):320-8., [[PMID:17635809]], [[http://calibre.mworld.com/m/m.w?lp=GetStory&id=279597241]]

SÃlvia Vilarinho, Kouetsu Ogasawara, Stephen Nishimura, Lewis L. Lanier, and Jody L. Baron 
'''Blockade of [[NKG2D]] on [[NKT cell]]s prevents hepatitis and the acute immune response to hepatitis B virus''' 
[http://www.pnas.org/cgi/content/short/0708968104v1 Proc. Natl. Acad. Sci. USA, 10.1073/pnas.0708968104]

==November 5th, Meltwater News & Blood/JI CiteTrack==
Jim Kim, Catherine K. Chang, Tracy Hayden, Feng-Chun Liu, Jonathan Benjamin, Jessica A. Hamerman, Lewis L. Lanier and Sang-Mo Kang 
'''The Activating Immunoreceptor [[NKG2D]] and Its Ligands Are Involved in Allograft Transplant Rejection''' 
[http://www.jimmunol.org/cgi/content/abstract/179/10/6416 The Journal of Immunology, 2007, 179: 6416-6420.]

Stern-Ginossar, N., Nedvetzki, S., Markel, G., Gazit, R., Betser-Cohen, G., Achdout, H., Aker, M., Blumberg, R. S., Davis, D.M., Appelmelk, B., Mandelboim, O. 
'''Intercellular Transfer of Carcinoembryonic Antigen from Tumor Cells to NK Cells''' 
[http://www.jimmunol.org/cgi/content/abstract/179/7/4424?ct J Immunol 2007 179: p. 4424-4434], NKref0546

Ebihara, T., Masuda, H., Akazawa, T., Shingai, M., Kikuta, H., Ariga, T., Matsumoto, M., Seya, T. 
'''Induction of [[NKG2D]] ligands on human dendritic cells by [[TLR]] ligand stimulation and RNA virus infection''' 
[http://intimm.oxfordjournals.org/cgi/content/abstract/dxm073v1?ct Int Immunol 2007 0: p. dxm073v1-dxm073], NKref0547

==November 4th, PubCrawler==
Shi YY, Ling B, Zhou Y, Gao T, Feng DQ, Xiao M, Feng L. 
'''Interferon-gamma Expression in Natural Killer Cells and Natural Killer T Cells Is Suppressed in Early Pregnancy.''' 
Cell Mol Immunol. 2007 Oct;4(5):389-394., [[PMID:17976320]]

Park S, Cheon S, Cho D. 
'''The Dual Effects of Interleukin-18 in Tumor Progression.''' 
Cell Mol Immunol. 2007 Oct;4(5):329-335., [[PMID:17976312]]

Cullen SP, Martin SJ. 
'''Mechanisms of granule-dependent killing.''' 
Cell Death Differ. 2007 Nov 2;. Epub, [[PMID:17975553]]

Zahran WA, Ghonaim MM, Koura BA, El-Banna H, Ali SM, El-Sheikh N. 
'''Human natural killer T cells (NKT), NK and T cells in pulmonary tuberculosis: potential indicators for disease activity and prognosis.''' 
Egypt J Immunol. 2006;13(1):67-78., [[PMID:17974151]]

Konjevic G, Jovic V, Vuletic A, Radulovic S, Jelic S, Spuzic I. 
'''CD69 on CD56+ NK cells and response to chemoimmunotherapy in metastatic melanoma.''' 
Eur J Clin Invest. 2007 Nov;37(11):887-96., [[PMID:17973783]]

Cagnano E, Hershkovitz O, Zilka A, Bar-Ilan A, Golder A, Sion-Vardy N, Bogdanov-Berezovsky A, Mandelboim O, Benharroch D, Porgador A. 
'''Expression of Ligands to NKp46 in Benign and Malignant Melanocytes.''' 
J Invest Dermatol. 2007 Nov 1;. Epub, [[PMID:17972960]]

Gomes AQ, Correia DV, Silva-Santos B. 
'''Non-classical major histocompatibility complex proteins as determinants of tumour immunosurveillance.''' 
EMBO Rep. 2007 Nov;8(11):1024-30., [[PMID:17972902]]

Macdonald HR. 
'''NKT cells: In the beginning...''' 
Eur J Immunol. 2007 Oct 31;37(S1):111-115. Epub, [[PMID:17972354]]

Arjona A, Sarkar DK. 
'''Are Circadian Rhythms the Code of Hypothalamic-Immune Communication? Insights from Natural Killer Cells.''' 
Neurochem Res. 2007 Oct 27;. Epub, [[PMID:17965936]]

Walzer T, Chiossone L, Chaix J, Calver A, Carozzo C, Garrigue-Antar L, Jacques Y, Baratin M, Tomasello E, Vivier E. 
'''Natural killer cell trafficking in vivo requires a dedicated sphingosine 1-phosphate receptor.''' 
Nat Immunol. 2007 Oct 28;. Epub, [[PMID:17965716]]

Ruggeri L, Mancusi A, Burchielli E, Capanni M, Carotti A, Aloisi T, Aversa F, Martelli MF, Velardi A. 
'''NK cell alloreactivity and allogeneic hematopoietic stem cell transplantation.''' 
Blood Cells Mol Dis. 2007 Oct 25;. Epub, [[PMID:17964828]]

Terabe M, Berzofsky JA. 
'''NKT cells in immunoregulation of tumor immunity: a new immunoregulatory axis.''' 
Trends Immunol. 2007 Oct 24;. Epub, [[PMID:17964217]]

Sivori S, Falco M, Carlomagno S, Romeo E, Moretta L, Moretta A. 
'''Heterogeneity of TLR3 mRNA transcripts and responsiveness to poly (I:C) in human NK cells derived from different donors.''' 
Int Immunol. 2007 Oct 25;. Epub, [[PMID:17962643]]

Roda JM, Joshi T, Butchar JP, McAlees JW, Lehman A, Tridandapani S, Carson WE 3rd. 
'''The Activation of Natural Killer Cell Effector Functions by Cetuximab-Coated, Epidermal Growth Factor Receptor Positive Tumor Cells is Enhanced By Cytokines.''' 
Clin Cancer Res. 2007 Oct 25;. Epub, [[PMID:17962339]]

ose A, Baral R. 
'''Natural killer cell mediated cytotoxicity of tumor cells initiated by neem leaf preparation is associated with CD40-CD40L-mediated endogenous production of interleukin-12.''' 
Hum Immunol. 2007 Oct;68(10):823-831., [[PMID:17961770]]

Huhn MH, Hultcrantz M, Lind K, Ljunggren HG, Malmberg KJ, Flodstrom-Tullberg M. 
'''IFN-gamma production dominates the early human natural killer cell response to Coxsackievirus infection.''' 
Cell Microbiol. 2007 Oct 24;. Epub, [[PMID:17961184]]

Moga E, Alvarez E, Canto E, Vidal S, Rodriguez-Sanchez JL, Sierra J, Briones J. 
'''NK cells stimulated with IL-15 or CpG ODN enhance rituximab-dependent cellular cytotoxicity against B-cell lymphoma.''' 
Exp Hematol. 2007 Oct 22;. Epub, [[PMID:17959301]]

Spolski R, Leonard WJ. 
'''Interleukin-21: Basic Biology and Implications for Cancer and Autoimmunity.''' 
Annu Rev Immunol. 2007 Oct 22;. Epub, [[PMID:17953510]]

Horng T, Bezbradica JS, Medzhitov R. 
'''NKG2D signaling is coupled to the interleukin 15 receptor signaling pathway.''' 
Nat Immunol. 2007 Oct 21;. Epub, [[PMID:17952078]]

Spaggiari GM, Capobianco A, Abdelrazik H, Becchetti F, Mingari MC, Moretta L. 
'''Mesenchymal stem cells inhibit natural killer cell proliferation, cytotoxicity and cytokine production: role of indoleamine 2,3-dioxygenase and prostaglandin E2.''' 
Blood. 2007 Oct 19;. Epub, [[PMID:17951526]]

Koh LP, Rizzieri DA, Chao NJ. 
'''Allogeneic hematopoietic stem cell transplant using mismatched/haploidentical donors.''' 
Biol Blood Marrow Transplant. 2007 Nov;13(11):1249-67., [[PMID:17950913]]

Fuhshuku KI, Hongo N, Tashiro T, Masuda Y, Nakagawa R, Seino KI, Taniguchi M, Mori K. 
'''RCAI-8, 9, 18, 19, and 49-52, conformationally restricted analogues of KRN7000 with an azetidine or a pyrrolidine ring: Their synthesis and bioactivity for mouse natural killer T cells to produce cytokines.''' 
Bioorg Med Chem. 2007 Oct 10;. Epub, [[PMID:17950609]]

Velikovsky CA, Deng L, Chlewicki LK, Fernandez MM, Kumar V, Mariuzza RA. 
'''Structure of Natural Killer Receptor 2B4 Bound to CD48 Reveals Basis for Heterophilic Recognition in Signaling Lymphocyte Activation Molecule Family.''' 
Immunity. 2007 Oct 17;. Epub, [[PMID:17950006]]

Paget C, Mallevaey T, Speak AO, Torres D, Fontaine J, Sheehan KC, Capron M, Ryffel B, Faveeuw C, Leite de Moraes M, Platt F, Trottein F. 
'''Activation of Invariant NKT Cells by Toll-like Receptor 9-Stimulated Dendritic Cells Requires Type I Interferon and Charged Glycosphingolipids.''' 
Immunity. 2007 Oct 17;. Epub, [[PMID:17950005]]

Nishio S, Yamada N, Ohyama H, Yamanegi K, Nakasho K, Hata M, Nakamura Y, Fukunaga S, Futani H, Yoshiya S, Ueda H, Taniguchi M, Okamura H, Terada N. 
'''Enhanced suppression of pulmonary metastasis of malignant melanoma cells by combined administration of alpha-galactosylceramide and interleukin-18.''' 
Cancer Sci. 2007 Oct 19;. Epub, [[PMID:17949451]]

Madjd Z, Spendlove I, Moss R, Bevin S, Pinder SE, Watson NF, Ellis I, Durrant LG. 
'''Upregulation of MICA on high-grade invasive operable breast carcinoma.''' 
Cancer Immun. 2007 Oct 22;7:17., [[PMID:17948965]]

==October 24th, Blood CiteTrack & Table of Contents==
Tha-In, T., Metselaar, H. J., Tilanus, H. W., Groothuismink, Z. M. A., Kuipers, E. J., de Man, R. A., Kwekkeboom, J. 
'''Intravenous immunoglobulins suppress T-cell priming by modulating the bidirectional [[interaction between dendritic cells and natural killer cells]]''' 
[http://bloodjournal.hematologylibrary.org/cgi/content/abstract/110/9/3253?ct Blood 2007 110: p. 3253-3262], NKref0545

Kim, N., Saudemont, A., Webb, L., Camps, M., Ruckle, T., Hirsch, E., Turner, M., Colucci, F. 
'''The p110delta catalytic isoform of PI3K is a key player in NK-cell development and cytokine secretion''' 
[http://bloodjournal.hematologylibrary.org/cgi/content/abstract/110/9/3202?ct Blood 2007 110: p. 3202-3208], NKref0544

==October 20th, PubCrawler==
Chan CW, Housseau F. 
'''The 'kiss of death' by dendritic cells to cancer cells.''' 
Cell Death Differ. 2007 Oct 19;. Epub, [[PMID:17948029]]

Yu J, Heller G, Chewning J, Kim S, Yokoyama WM, Hsu KC. 
'''Hierarchy of the Human Natural Killer Cell Response Is Determined by Class and Quantity of Inhibitory Receptors for Self-HLA-B and HLA-C Ligands.''' 
J Immunol. 2007 Nov 1;179(9):5977-89., [[PMID:17947671]]

Shi J, Tricot GJ, Garg TK, Malaviarachchi PA, Szmania SM, Kellum RE, Storrie B, Mulder A, Shaughnessy JD Jr, Barlogie B, van Rhee F. 
'''Bortezomib down-regulates the cell surface expression of HLA-class I and enhances natural killer cell-mediated lysis of myeloma.''' 
Blood. 2007 Oct 18;. Epub, [[PMID:17947507]]

Wingender G, Kronenberg M. 
'''The role of canonical Natural Killer T cells in mucosal immunity and inflammation.''' 
Am J Physiol Gastrointest Liver Physiol. 2007 Oct 18;. Epub, [[PMID:17947447]]

Yutkin V, Pode D, Pikarsky E, Mandelboim O. 
'''The Expression Level of Ligands for Natural Killer Cell Receptors Predicts Response to Bacillus Calmette-Guerin Therapy: A Pilot Study.''' 
J Urol. 2007 Oct 16;. Epub, [[PMID:17945285]]

Evans DL, Lynch KG, Benton T, Dube B, Gettes DR, Tustin NB, Lai JP, Metzger D, Douglas SD. 
'''Selective Serotonin Reuptake Inhibitor and Substance P Antagonist Enhancement of Natural Killer Cell Innate Immunity in Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome.''' 
Biol Psychiatry. 2007 Oct 16;. Epub, [[PMID:17945197]]

Chang CL, Tsai YC, He L, Wu TC, Hung CF. 
'''Cancer immunotherapy using irradiated tumor cells secreting [[heat shock protein 70]].''' 
Cancer Res. 2007 Oct 15;67(20):10047-57., [[PMID:17942939]]

Zimmer J, Bausinger H, Andres E, Donato L, Hanau D, Hentges F, Moretta A, de la Salle H. 
'''Phenotypic studies of natural killer cell subsets in human transporter associated with antigen processing deficiency.''' 
PLoS ONE. 2007 Oct 17;2(10):e1033., [[PMID:17940597]]

Meyer EH, Dekruyff RH, Umetsu DT. 
'''T Cells and NKT Cells in the Pathogenesis of Asthma.''' 
Annu Rev Med. 2007 Oct 11;. Epub, [[PMID:17937589]]

Tsirigotis P, Economopoulos T. 
'''Monoclonal antibodies in the treatment of lymphoid malignancies.''' 
J Steroid Biochem Mol Biol. 2007 Sep 7;. Epub, [[PMID:17935974]]

Yue WF, Yao ML, Liu JM, Li GL, Li XH, Wu XF, Deng W, Sun HX, Zhou JY, Zhang CX, Miao YG. 
'''Manganese superoxide dismutase expressed in silkworm larvae, Bombyx mori L enhances the NK activity and splenocyte proliferation against Sarcoma 180 tumor cells in vivo.''' 
Mol Biol Rep. 2007 Oct 14;. Epub, [[PMID:17934870]]

Kanto T, Hayashi N. 
'''Innate immunity in hepatitis C virus infection: Interplay among dendritic cells, natural killer cells and natural killer T cells.''' 
Hepatol Res. 2007 Oct;37 Suppl 3:S319-26., [[PMID:17931181]]

Vosshenrich CA, Lesjean-Pottier S, Hasan M, Goff OR, Corcuff E, Mandelboim O, Di Santo JP. 
'''CD11cloB220+ interferon-producing killer dendritic cells are activated natural killer cells.''' 
J Exp Med. 2007 Oct 8;. Epub, [[PMID:17923507]]

Caminschi I, Ahmet F, Heger K, Brady J, Nutt SL, Vremec D, Pietersz S, Lahoud MH, Schofield L, Hansen DS, O'keeffe M, Smyth MJ, Bedoui S, Davey GM, Villadangos JA, Heath WR, Shortman K. 
'''Putative IKDCs are functionally and developmentally similar to natural killer cells, but not to dendritic cells.''' 
J Exp Med. 2007 Oct 8;. Epub, [[PMID:17923506]]

Blasius AL, Barchet W, Cella M, Colonna M. 
'''Development and function of murine B220+CD11c+NK1.1+ cells identify them as a subset of NK cells.''' 
J Exp Med. 2007 Oct 8;. Epub, [[PMID:17923504]]

Costa IG, Roepcke S, Schliep A. 
'''Gene expression trees in lymphoid development.''' 
BMC Immunol. 2007 Oct 9;8(1):25. Epub, [[PMID:17925013]]

Goldszmid RS, Bafica A, Jankovic D, Feng CG, Caspar P, Winkler-Pickett R, Trinchieri G, Sher A. 
'''TAP-1 indirectly regulates CD4+ T cell priming in Toxoplasma gondii infection by controlling NK cell IFN-{gamma} production.''' 
J Exp Med. 2007 Oct 8;. Epub, [[PMID:17923502]]

Hadinedoushan H, Mirahmadian M, Aflatounian A. 
'''Increased Natural Killer Cell Cytotoxicity and IL-2 Production in Recurrent Spontaneous Abortion.''' 
Am J Reprod Immunol. 2007 Nov;58(5):409-14., [[PMID:17922693]]

von Muller L, Klemm A, Durmus N, Weiss M, Suger-Wiedeck H, Schneider M, Hampl W, Mertens T. 
'''Cellular immunity and active human cytomegalovirus infection in patients with septic shock.''' 
J Infect Dis. 2007 Nov 1;196(9):1288-95., [[PMID:17922392]]

Fan YY, Yang BY, Wu CY. 
'''Phenotypically and functionally distinct [[subset]]s of [[natural killer cell]]s in human PBMCs.''' 
Cell Biol Int. 2007 Sep 7;., [[PMID:17920947]]

Zimmer J, Michel T, Andres E, Hentges F. 
'''Up-regulation of [[NKG2D]] ligands by AML cells to increase sensitivity to [[NK cell]]s: The tumour might strike back Comment on "Differentiation-promoting drugs up-regulate [[NKG2D]] ligand expression and enhance the susceptibility of acute myeloid leukemia cells to natural killer cell-mediated lysis" by Rohner et al. [Leuk Res 2007;31:1393-402].''' 
Leuk Res. 2007 Oct 5;. Epub, [[PMID:17920678]]

Multhoff G. 
'''[[Heat shock protein 70]] ([[Hsp70]]): Membrane location, export and immunological relevance.''' 
Methods. 2007 Nov;43(3):229-37., [[PMID:17920520]]

==October 8th, PubCrawler==
Castriconi R, Dondero A, Negri F, Bellora F, Nozza P, Carnemolla B, Raso A, Moretta L, Moretta A, Bottino C. 
'''Both CD133(+) and CD133(-) medulloblastoma cell lines express ligands for triggering NK receptors and are susceptible to NK-mediated cytotoxicity.''' 
Eur J Immunol. 2007 Oct 4;. Epub, [[PMID:17918205]]

Chaleff S, Otto M, Barfield R, Leimig T, Iyengar R, Martin J, Holiday M, Houston J, Geiger T, Huppert V, Handgretinger R. 
'''A large-scale method for the selective depletion of alphabeta T lymphocytes from PBSC for allogeneic transplantation.''' 
Cytotherapy. 2007 Oct 4;:1-9. Epub, [[PMID:17917892]]

Ballas ZK. 
'''Modulation of NK cell activity by CpG oligodeoxynucleotides.''' 
Immunol Res. 2007 Nov;39(1-3):15-21., [[PMID:17917052]]

Niemeyer M, Darmoise A, Mollenkopf HJ, Hahnke K, Hurwitz R, Besra GS, Schaible UE, Kaufmann SH. 
'''Natural killer T-cell characterization through gene expression profiling: an account of versatility bridging T helper type 1 (Th1), Th2 and Th17 immune responses.''' 
Immunology. 2007 Oct 4;. Epub, [[PMID:17916165]]

Taniguchi T, Tachikawa S, Kanda Y, Kawamura T, Tomiyama-Miyaji C, Li C, Watanabe H, Sekikawa H, Abo T. 
'''Malaria protection in beta(2)-microglobulin-deficient mice lacking major histocompatibility complex class I antigens: essential role of innate immunity, including gammadeltaT cells.''' 
Immunology. 2007 Oct 4;. Epub, [[PMID:17916163]]

Oshimi K. 
'''Progress in understanding and managing natural killer-cell malignancies.''' 
Br J Haematol. 2007 Oct 3;. Epub, [[PMID:17916099]]

Pintaric M, Gerner W, Saalmuller A. 
'''Synergistic effects of IL-2, IL-12 and IL-18 on cytolytic activity, perforin expression and IFN-gamma production of porcine natural killer cells.''' 
Vet Immunol Immunopathol. 2007 Aug 25;. Epub, [[PMID:17913242]]

Gambelunghe G, Brozzetti A, Ghaderi M, Candeloro P, Tortoioli C, Falorni A. 
'''MICA Gene Polymorphism in the Pathogenesis of Type 1 Diabetes.''' 
Ann N Y Acad Sci. 2007 Sep;1110:92-8., [[PMID:17911424]]

Kabalak G, Koch S, Dobberstein B, The YH, Matthias T, Schnarr S, Schmidt RE, Witte T. 
'''Immunoglobulin-like Transcripts as Risk Genes for Autoimmunity.''' 
Ann N Y Acad Sci. 2007 Sep;1110:10-4., [[PMID:17911415]]

Jiang YJ, Zhang ZN, Diao YY, Geng WQ, Dai D, Liu J, Wang YN, Zhang M, Han XX, Shang H. 
'''Distribution of natural killer cell receptors in HIV infected individuals.''' 
Chin Med J (Engl). 2007 Sep 5;120(17):1544-8., [[PMID:17908466]]

Zhang H, Meadows GG. 
'''Chronic alcohol consumption perturbs the balance between thymus-derived and bone marrow-derived natural killer cells in the spleen.''' 
J Leukoc Biol. 2007 Sep 28;. Epub, [[PMID:17906116]]

Segal BM. 
'''The role of natural killer cells in curbing neuroinflammation.''' 
J Neuroimmunol. 2007 Sep 27;. Epub, [[PMID:17904646]]

Khan N. 
'''The immunological burden of human cytomegalovirus infection.''' 
Arch Immunol Ther Exp (Warsz). 2007 Oct 1;. Epub, [[PMID:17906950]]

Fink LN, Zeuthen LH, Ferlazzo G, Frokiaer H. 
'''Human antigen-presenting cells respond differently to gut-derived probiotic bacteria but mediate similar strain-dependent NK and T cell activation.''' 
FEMS Immunol Med Microbiol. 2007 Sep 28;. Epub, [[PMID:17903206]]

Park HR, Jung U, Jo SK. 
'''Impairment of Natural Killer (NK) Cells is an Important Factor in a Weak Th1-like Response in Irradiated Mice.''' 
Radiat Res. 2007 Oct;168(4):446-52., [[PMID:17903039]]

==October 3rd, PubCrawler & Manual Journal Screen==
Cecchetti S, Spadaro F, Lugini L, Podo F, Ramoni C. 
'''Functional role of phosphatidylcholine-specific phospholipase C in regulating CD16 membrane expression in natural killer cells.''' 
Eur J Immunol. 2007 Sep 26;37(10):2912-2922. Epub, [[PMID:17899539]]

Korthals M, Safaian N, Kronenwett R, Maihofer D, Schott M, Papewalis C, Diaz Blanco E, Winter M, Czibere A, Haas R, Kobbe G, Fenk R. 
'''Monocyte derived dendritic cells generated by IFN-alpha acquire mature dendritic and natural killer cell properties as shown by gene expression analysis.''' 
J Transl Med. 2007 Sep 25;5(1):46. Epub, [[PMID:17894866]]

Lambiase A, Normando EM, Vitiello L, Micera A, Sacchetti M, Perrella E, Racioppi L, Bonini S, Bonini S. 
'''Natural killer cells in vernal keratoconjunctivitis.''' 
Mol Vis. 2007 Aug 30;13:1562-7., [[PMID:17893656]]

Jukes JP, Wood KJ, Jones ND. 
'''Natural killer T cells: a bridge to tolerance or a pathway to rejection?''' 
Transplantation. 2007 Sep 27;84(6):679-81., [[PMID:17893598]]

Borg NA, Kjer-Nielsen L, McCluskey J, Rossjohn J. 
'''Structural insight into natural killer T cell receptor recognition of CD1d.''' 
Adv Exp Med Biol. 2007;598:20-34., [[PMID:17892202]]

Marcenaro E, Della Chiesa M, Ferranti B, Moretta A. 
'''In the thick of the fray: NK cells in inflamed tissues.''' 
Adv Exp Med Biol. 2007;598:12-9., [[PMID:17892201]]

Lauzon NM, Mian F, Ashkar AA. 
'''Toll-like receptors, natural killer cells and innate immunity.''' 
Adv Exp Med Biol. 2007;598:1-11., [[PMID:17892200]]

Gao JQ, Okada N, Mayumi T, Nakagawa S. 
'''Immune Cell Recruitment and Cell-Based System for Cancer Therapy.''' 
Pharm Res. 2007 Sep 22;. Epub, [[PMID:17891483]]

Blewett MM. 
'''Hypothesized role of galactocerebroside and NKT cells in the etiology of multiple sclerosis.''' 
Med Hypotheses. 2007 Sep 20;. Epub, [[PMID:17889444]]

Hart AN, Zaske LA, Patterson KM, Drapeau C, Jensen GS. 
'''Natural Killer Cell Activation and Modulation of Chemokine Receptor Profile In Vitro by an Extract from the Cyanophyta Aphanizomenon flos-aquae.''' 
J Med Food. 2007 Sep;10(3):435-41., [[PMID:17887936]]

Zhai Z, Liu Y, Wu L, Senchina DS, Wurtele ES, Murphy PA, Kohut ML, Cunnick JE. 
'''Enhancement of innate and adaptive immune functions by multiple echinacea species.''' 
J Med Food. 2007 Sep;10(3):423-34.m [[PMID:17887935]]

Lanier LL. 
'''Back to the future - defining NK cells and T cells.''' 
Eur J Immunol. 2007 Jun;37(6):1424-6., [[PMID:17523211]]

Stewart CA, Walzer T, Robbins SH, Malissen B, Vivier E, Prinz I. 
'''Germ-line and rearranged Tcrd transcription distinguish bona fide NK cells and NK-like gammadelta T cells.''' 
Eur J Immunol. 2007 Jun;37(6):1442-52., [[PMID:17492716]]

D'Ombrain MC, Hansen DS, Simpson KM, Schofield L. 
'''gammadelta-T cells expressing NK receptors predominate over NK cells and conventional T cells in the innate IFN-gamma response to Plasmodium falciparum malaria.''' 
Eur J Immunol. 2007 Jul;37(7):1864-73., [[PMID:17557374]]

GÃ³mez-Lozano N, Trompeter HI, de Pablo R, EstefanÃa E, Uhrberg M, Vilches C. 
'''Epigenetic silencing of potentially functional [[KIR2DL5]] alleles: Implications for the acquisition of [[KIR repertoire]]s by [[NK cell]]s.''' 
Eur J Immunol. 2007 Jul;37(7):1954-65., [[PMID:17557377]]

==Quarterly Archive of [[NK Journal Screening]] Results==
{{NK Papers Archive}}

Natural killer cell development

Volker Huppert — Wed, 20 Feb 2008 23:24:56 GMT

Summary:

==References==
Boos MD, Ramirez K, Kee BL. 
'''Extrinsic and intrinsic regulation of early [[natural killer cell development]].''' 
Immunol Res. 2008;40(3):193-207., [[PMID:18266115]]

Tonsilar NK Cell

Volker Huppert — Wed, 20 Feb 2008 23:23:09 GMT

Summary:

==Introduction==

==References==
Strowig T, Brilot F, Arrey F, Bougras G, Thomas D, Muller WA, MÃ¼nz C. 
'''[[Tonsilar NK Cell]]s Restrict B Cell Transformation by the Epstein-Barr Virus via IFN-gamma.''' 
PLoS Pathog. 2008 Feb 8;4(2):e27. Epub, [[PMID:18266470]], [[http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=18266470 Free Fulltext @ PubMedCentral]], [[http://pathogens.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.ppat.0040027&ct=1 Free Fulltext @ PLoS]]

==Weblinks==
* [[WikiPedia:Tonsil]]

Cytokine-induced killer cell

Volker Huppert — Sun, 27 Jan 2008 16:45:23 GMT

Summary:

==References==
Giancola R, Olioso P, Di Riti M, Capone A, Contento A, Pompetti F, Iacone A. 
'''Evaluation of an automated closed fluid management device for processing [[expand]]ed [[cytokine-induced killer cell]]s to use in immunotherapy programs for cancer.''' 
Transfusion. 2008 Jan 15;. Epub, [[PMID:18208417]]

NK Papers Q3 2007

Volker Huppert — Wed, 09 Jan 2008 01:12:22 GMT

Summary:

==September 24th, PubCrawler==
Strom A, Wigren M, Hultgardh-Nilsson A, Saxena A, Gomez MF, Cardell S, Fredrikson GN, Nilsson J. 
'''Involvement of the CD1d Natural Killer T Cell Pathway in Neointima Formation After Vascular Injury.''' 
Circ Res. 2007 Sep 20;. Epub, [[PMID:17885216]]

Koh LP, Chao NJ. 
'''Nonmyeloablative allogeneic hematopoietic stem cell transplant using mismatched/haploidentical donors: A review.''' 
Blood Cells Mol Dis. 2007 Sep 18;. Epub, [[PMID:17884641]]

Sambrook JG, Beck S. 
'''Evolutionary vignettes of natural killer cell receptors.''' 
Curr Opin Immunol. 2007 Sep 18;. Epub, [[PMID:17884420]]

Schellekens J, Rozemuller EH, Petersen EJ, van den Tweel JG, Verdonck LF, Tilanus MG. 
'''Patients benefit from the addition of KIR repertoire data to the donor selection procedure for unrelated haematopoietic stem cell transplantation.''' 
Mol Immunol. 2007 Sep 17;. Epub, [[PMID:17881057]]

El-Sherbiny YM, Meade JL, Holmes TD, McGonagle D, Mackie SL, Morgan AW, Cook G, Feyler S, Richards SJ, Davies FE, Morgan GJ, Cook GP. 
'''The Requirement for DNAM-1, NKG2D, and NKp46 in the Natural Killer Cell-Mediated Killing of Myeloma Cells.''' 
Cancer Res. 2007 Sep 15;67(18):8444-9., [[PMID:17875681]]

Andzelm MM, Chen X, Krzewski K, Orange JS, Strominger JL. 
'''Myosin IIA is required for cytolytic granule exocytosis in human NK cells.''' 
J Exp Med. 2007 Sep 17;. Epub, [[PMID:17875677]]

Trotta R, Ciarlariello D, Col JD, Allard J 2nd, Neviani P, Santhanam R, Mao H, Becknell B, Yu J, Ferketich AK, Thomas B, Modi A, Blaser BW, Perrotti D, Caligiuri MA. 
'''The PP2A inhibitor SET regulates natural killer cell IFN-{gamma} production.''' 
J Exp Med. 2007 Sep 17;. Epub, [[PMID:17875674]]

Jurisic V, Srdic T, Konjevic G, Markovic O, Colovic M. 
'''Clinical stage-depending decrease of NK cell activity in multiple myeloma patients.''' 
Med Oncol. 2007;24(3):312-7., [[PMID:17873307]]

Bethge WA, Faul C, Bornhauser M, Stuhler G, Beelen DW, Lang P, Stelljes M, Vogel W, Hagele M, Handgretinger R, Kanz L. 
'''Haploidentical allogeneic hematopoietic cell transplantation in adults using CD3/CD19 depletion and reduced intensity conditioning: An update.''' 
Blood Cells Mol Dis. 2007 Sep 13;. Epub, [[PMID:17869547]]

Stavenhagen JB, Gorlatov S, Tuaillon N, Rankin CT, Li H, Burke S, Huang L, Johnson S, Bonvini E, Koenig S. 
'''Fc Optimization of Therapeutic Antibodies Enhances Their Ability to Kill Tumor Cells In vitro and Controls Tumor Expansion In vivo via Low-Affinity Activating Fc{gamma} Receptors.''' 
Cancer Res. 2007 Sep 15;67(18):8882-90., [[PMID:17875730]]

==September 20th, manual screening==
Park SW, Bae JH, Kim SD, Son YO, Kim JY, Park HJ, Lee CH, Park DY, Kim JY, Lee MK, Chung BS, Kim SH, Kang CD. 
'''Comparison of level of NKG2D ligands between normal and tumor tissue using multiplex RT-PCR.''' 
Cancer Invest. 2007 Aug;25(5):299-307., [[PMID:17661204]]

==September 19th, JI CiteTrack==
El-Sherbiny, Y. M., Meade, J. L., Holmes, T. D., McGonagle, D., Mackie, S. L., Morgan, A. W., Cook, G., Feyler, S., Richards, S. J., Davies, F. E., Morgan, G. J., Cook, G. P. 
'''The Requirement for DNAM-1, NKG2D, and NKp46 in the Natural Killer Cell-Mediated Killing of Myeloma Cells''' 
[http://cancerres.aacrjournals.org/cgi/content/abstract/67/18/8444?ct Cancer Res 2007 67: p. 8444-8449]

==September 16th, PubCrawler==
Yoon SR, Chung JW, Choi I. 
'''Development of natural killer cells from hematopoietic stem cells.''' 
Mol Cells. 2007 Aug 31;24(1):1-8., [[PMID:17846493]]

Miyagi T, Gil MP, Wang X, Louten J, Chu WM, Biron CA. 
'''High basal STAT4 balanced by STAT1 induction to control type 1 interferon effects in natural killer cells.''' 
J Exp Med. 2007 Sep 10;. Epub, [[PMID:17846149]]

Rajeswari DN, Selvaraj P, Raghavan S, Jawahar MS, Narayanan PR. 
'''Influence of HLA-DR2 on perforin-positive cells in pulmonary tuberculosis.''' 
Int J Immunogenet. 2007 Oct;34(5):379-84., [[PMID:17845310]]

Bottley G, Watherston OG, Hiew YL, Norrild B, Cook GP, Blair GE. 
'''High-risk human papillomavirus E7 expression reduces cell-surface MHC class I molecules and increases susceptibility to natural killer cells.''' 
Oncogene. 2007 Sep 10;. Epub, [[PMID:17828295]]

Scott-Browne JP, Matsuda JL, Mallevaey T, White J, Borg NA, McCluskey J, Rossjohn J, Kappler J, Marrack P, Gapin L. 
'''Germline-encoded recognition of diverse glycolipids by natural killer T cells.''' 
Nat Immunol. 2007 Sep 9;. Epub, [[PMID:17828267]]

Esendagli G, Bruderek K, Goldmann T, Busche A, Branscheid D, Vollmer E, Brandau S. 
'''Malignant and non-malignant lung tissue areas are differentially populated by natural killer cells and regulatory T cells in non-small cell lung cancer.''' 
Lung Cancer. 2007 Sep 6;. Epub, [[PMID:17825949]]

Stronge VS, Salio M, Jones EY, Cerundolo V. 
'''A closer look at CD1d molecules: new horizons in studying NKT cells.''' 
Trends Immunol. 2007 Sep 6;. Epub, [[PMID:17825624]]

Passweg JR, Huard B, Tiercy JM, Roosnek E. 
'''HLA and KIR polymorphisms affect NK-cell anti-tumor activity.''' 
Trends Immunol. 2007 Sep 6;. Epub, [[PMID:17825623]]

==September 11th, PubCrawler==
Oling V, Marttila J, Knip M, Simell O, Ilonen J. 
'''Circulating CD4+CD25 high regulatory T cells and natural killer T cells in children with newly diagnosed type 1 diabetes or with diabetes-associated autoantibodies.''' 
Ann N Y Acad Sci. 2007 Jun;1107:363-72., [[PMID:17804564]]

Carp HJ, Shoenfeld Y. 
'''Recurrent spontaneous abortions in antiphospholipid syndrome: natural killer cells an additional mechanism in a multi factorial process.''' 
Rheumatology (Oxford). 2007 Sep 5;. Epub, [[PMID:17804454]]

Xie L, Pries R, Kesselring R, Wulff S, Wollenberg B. 
'''Head and neck cancer triggers the internalization of TLR3 in natural killer cells.''' 
Int J Mol Med. 2007 Oct;20(4):493-9., [[PMID:17786279]]

Ilhan F, Kandi B, Akbulut H, Turgut D, Cicek D. 
'''Atopic dermatitis and valpha24 natural killer T cells.''' 
Skinmed. 2007 Sep-Oct;6(5):218-20., [[PMID:17786098]]

Allende ML, Zhou D, Kalkofen DN, Benhamed S, Tuymetova G, Borowski C, Bendelac A, Proia RL. 
'''S1P1 receptor expression regulates emergence of NKT cells in peripheral tissues.''' 
FASEB J. 2007 Sep 4;. Epub, [[PMID:17785606]]

Poggi A, Prevosto C, Zancolli M, Canevali P, Musso A, Zocchi MR. 
'''[[NKG2D]] and [[Natural Cytotoxicity Receptor]]s Are Involved in Natural Killer Cell Interaction with Self-Antigen Presenting Cells and Stromal Cells.''' 
Ann N Y Acad Sci. 2007 Sep;1109:47-57., [[PMID:17785290]]

Dong ZJ, Wei HM, Sun R, Tian ZG. 
'''The roles of innate immune cells in liver injury and regeneration.''' 
Cell Mol Immunol. 2007 Aug;4(4):241-52., [[PMID:17764614]]

Hou Q, Zhao T, Zhang H, Lu H, Zhang Q, Sun L, Fan Z. 
'''[[Granzyme H]] induces apoptosis of target tumor cells characterized by DNA fragmentation and Bid-dependent mitochondrial damage.''' 
Mol Immunol. 2007 Aug 31;. Epub, [[PMID:17765974]]

==September 2nd, PubCrawler==
Harrington L, Srikanth CV, Antony R, Shi HN, Cherayil BJ. 
'''A role for natural killer cells in intestinal inflammation caused by infection with Salmonella enterica serovar Typhimurium.''' 
FEMS Immunol Med Microbiol. 2007 Aug 29;. Epub, [[PMID:17727655]]

Baba T, Hanagiri T, Ichiki Y, Kuroda K, Shigematsu Y, Mizukami M, Sugaya M, Takenoyama M, Sugio K, Yasumoto K. 
'''Lack and restoration of sensitivity of lung cancer cells to cellular attack with special reference to expression of human leukocyte antigen class I and/or major histocompatibility complex class I chain related molecules A/B.''' 
Cancer Sci. 2007 Aug 28;. Epub, [[PMID:17725806]]

Xu CF, Yu CH, Li YM, Xu L, Du J, Shen Z. 
'''Association of the frequency of peripheral natural killer T cells with nonalcoholic fatty liver disease.''' 
World J Gastroenterol. 2007 Sep 7;13(33):4504-8., [[PMID:17724809]]

Robbins SH, Bessou G, Cornillon A, Zucchini N, Rupp B, Ruzsics Z, Sacher T, Tomasello E, Vivier E, Koszinowski UH, Dalod M. 
'''Natural Killer Cells Promote Early CD8 T Cell Responses against Cytomegalovirus.''' 
PLoS Pathog. 2007 Aug 24;3(8):e123. Epub, [[PMID:17722980]]

Wang L, Halliday D, Johnson PM, Christmas SE. 
'''Expression of complement regulatory proteins on human natural killer cell subsets.''' 
Immunol Lett. 2007 Aug 9;. Epub, [[PMID:17719652]]

Muller T, Uherek C, Maki G, Chow KU, Schimpf A, Klingemann HG, Tonn T, Wels WS. 
'''Expression of a CD20-specific chimeric antigen receptor enhances cytotoxic activity of NK cells and overcomes NK-resistance of lymphoma and leukemia cells.''' 
Cancer Immunol Immunother. 2007 Aug 24;. Epub, [[PMID:17717662]]

Huntington ND, Vosshenrich CA, Di Santo JP. 
'''Developmental pathways that generate natural-killer-cell diversity in mice and humans.''' 
Nat Rev Immunol. 2007 Sep;7(9):703-14., [[PMID:17717540]]

van Weel V, Toes RE, Seghers L, Deckers MM, de Vries MR, Eilers PH, Sipkens J, Schepers A, Eefting D, van Hinsbergh VW, van Bockel JH, Quax PH. 
'''Natural Killer Cells and CD4+ T-Cells Modulate Collateral Artery Development.''' 
Arterioscler Thromb Vasc Biol. 2007 Aug 23;. Epub, [[PMID:17717295]]

Zeissig S, Kaser A, Dougan SK, Nieuwenhuis EE, Blumberg RS. 
'''Role of NKT cells in Intestinal Immunity.''' 
Am J Physiol Gastrointest Liver Physiol. 2007 Aug 23;. Epub, [[PMID:17717040]]

Yang X. 
'''Natural killer T (NKT) cell subsets in chlamydial infections.''' 
Adv Exp Med Biol. 2007;601:243-6., [[PMID:17713011]]

Orange JS. 
'''The lytic NK cell immunological synapse and sequential steps in its formation.''' 
Adv Exp Med Biol. 2007;601:225-33., [[PMID:17713009]]

Yamamoto H, Okamoto Y, Horiguchi S, Kunii N, Yonekura S, Nakayama T. 
'''Detection of natural killer T cells in the sinus mucosa from asthmatics with chronic sinusitis.''' 
Allergy. 2007 Aug 17;. Epub, [[PMID:17711556]]

Song L, Ara T, Wu HW, Woo CW, Reynolds CP, Seeger RC, Declerck YA, Thiele CJ, Sposto R, Metelitsa LS. 
'''Oncogene MYCN regulates localization of NKT cells to the site of disease in neuroblastoma.''' 
J Clin Invest. 2007 Aug 16;. Epub, [[PMID:17710228]]

Ballan WM, Vu BA, Long BR, Loo CP, Michaelsson J, Barbour JD, Lanier LL, Wiznia AA, Abadi J, Fennelly GJ, Rosenberg MG, Nixon DF. 
'''Natural Killer Cells in Perinatally HIV-1-Infected Children Exhibit Less Degranulation Compared to HIV-1-Exposed Uninfected Children and Their Expression of KIR2DL3, NKG2C, and NKp46 Correlates with Disease Severity.''' 
J Immunol. 2007 Sep 1;179(5):3362-70., [[PMID:17709553]]

Schierloh P, Yokobori N, Aleman M, Landoni V, Geffner L, Musella RM, Castagnino J, Baldini M, Abbate E, de la Barrera SS, Sasiain MC. 
'''Mycobacterium tuberculosis-induced IFN-{gamma} Production by Natural Killer Cells Requires Cross-Talk with Antigen Presenting Cells Involving Toll-Like Receptors 2 and 4 and Mannose Receptor In Tuberculous Pleurisy.''' 
Infect Immun. 2007 Aug 20;. Epub, [[PMID:17709420]]

Burshtyn DN, Long EO. 
'''Regulation through inhibitory receptors: Lessons from natural killer cells.''' 
Trends Cell Biol. 1997 Dec;7(12):473-9., [[PMID:17709010]]

Seliger B, Schlaf G. 
'''Structure, expression and function of HLA-G in renal cell carcinoma.''' 
Semin Cancer Biol. 2007 Jul 13;. Epub, [[PMID:17707652]]

Kumano M, Hara I, Furukawa J, Oniki S, Nagai H, Miyake H, Fujisawa M. 
'''Interleukin-21 Activates Cytotoxic T Lymphocytes and Natural Killer Cells to Generate Antitumor Response in Mouse Renal Cell Carcinoma.''' 
J Urol. 2007 Aug 15;. Epub, [[PMID:17707061]]

Galandrini R, Porpora MG, Stoppacciaro A, Micucci F, Capuano C, Tassi I, Di Felice A, Benedetti-Panici P, Santoni A. 
'''Increased frequency of human leukocyte antigen-E inhibitory receptor CD94/NKG2A-expressing peritoneal natural killer cells in patients with endometriosis.''' 
Fertil Steril. 2007 Aug 11;. Epub, [[PMID:17706207]]

Carter C, Savic S, Cole J, Wood P. 
'''Natural killer cell receptor expression in patients with severe and recurrent Herpes simplex virus-1 (HSV-1) infections.''' 
Cell Immunol. 2007 Aug 10;. Epub, [[PMID:17706187]]

Perricone C, De Carolis C, Giacomelli R, Zaccari G, Cipriani P, Bizzi E, Perricone R. 
'''High levels of NK cells in the peripheral blood of patients affected with anti-phospholipid syndrome and recurrent spontaneous abortion: a potential new hypothesis.''' 
Rheumatology (Oxford). 2007 Aug 17;. Epub, [[PMID:17704519]]

==August 23rd, PubCrawler==
Mihara T, Nakashima M, Kuroiwa A, Akitake Y, Ono K, Hosokawa M, Yamada T, Takahashi M. 
'''Natural killer cells of Parkinson's disease patients are set up for activation: A possible role for innate immunity in the pathogenesis of this disease.''' 
Parkinsonism Relat Disord. 2007 Aug 14;. Epub, [[PMID:17702627]]

Hansen DS, D'Ombrain MC, Schofield L. 
'''The role of leukocytes bearing Natural Killer Complex receptors and Killer Immunoglobulin-like Receptors in the immunology of malaria.''' 
Curr Opin Immunol. 2007 Aug 14;. Epub, [[PMID:17702559]]

Srivastava MD, Thomas A, Srivastava BI, Check JH. 
'''Expression and modulation of progesterone induced blocking factor (PIBF) and innate immune factors in human leukemia cell lines by progesterone and mifepristone.''' 
Leuk Lymphoma. 2007 Aug;48(8):1610-7., [[PMID:17701593]]

Del Vecchio M, Bajetta E, Canova S, Lotze MT, Wesa A, Parmiani G, Anichini A. 
'''Interleukin-12: Biological Properties and Clinical Application.''' 
Clin Cancer Res. 2007 Aug 15;13(16):4677-4685., [[PMID:17699845]]

Norman PJ, Abi-Rached L, Gendzekhadze K, Korbel D, Gleimer M, Rowley D, Bruno D, Carrington CV, Chandanayingyong D, Chang YH, Crespi C, Saruhan-Direskeneli G, Fraser PA, Hameed K, Kamkamidze G, Koram KA, Layrisse Z, Matamoros N, Mila J, Park MH, Pitchappan RM, Ramdath DD, Shiau MY, Stephens HA, Struik S, Verity DH, Vaughan RW, Tyan D, Davis RW, Riley EM, Ronaghi M, Parham P. 
'''Unusual selection on the KIR3DL1/S1 natural killer cell receptor in Africans.''' 
Nat Genet. 2007 Aug 12;. Epub, [[PMID:17694054]]

Mihaylova I, Deruyter M, Rummens JL, Bosmans E, Maes M. 
'''Decreased expression of CD69 in chronic fatigue syndrome in relation to inflammatory markers: evidence for a severe disorder in the early activation of T lymphocytes and natural killer cells.''' 
Neuro Endocrinol Lett. 2007 Jul 11;28(4). Epub, [[PMID:17693977]]

Lazaris AC, Segas JV, Nikolopoulos TP, Patsouris ES. 
'''Tissue detection of natural killer cells in laryngeal carcinoma.''' 
Neoplasma. 2007;54(5):379-82., [[PMID:17688367]]

Moebius JM, Widera D, Schmitz J, Kaltschmidt C, Piechaczek C. 
'''Impact of polysialylated CD56 on natural killer cell cytotoxicity.''' 
BMC Immunol. 2007 Aug 6;8(1):13. Epub, [[PMID:17683591]]

Li Q, Kobayashi M, Kawada T. 
'''Organophosphorus pesticides induce apoptosis in human NK cells.''' 
Toxicology. 2007 Jul 5;. Epub, [[PMID:17681413]]

Chinen H, Matsuoka K, Sato T, Kamada N, Okamoto S, Hisamatsu T, Kobayashi T, Hasegawa H, Sugita A, Kinjo F, Fujita J, Hibi T. 
'''Lamina Propria c-kit(+) Immune Precursors Reside in Human Adult Intestine and Differentiate Into Natural Killer Cells.''' 
Gastroenterology. 2007 Aug;133(2):559-573., [[PMID:17681176]]

Santoni A, Zingoni A, Cerboni C, Gismondi A. 
'''Natural killer (NK) cells from killers to regulators: distinct features between peripheral blood and decidual NK cells.''' 
Am J Reprod Immunol. 2007 Sep;58(3):280-8., [[PMID:17681044]]

Liu XC, Liang H, Tian Z, Ruan YS, Zhang L, Chen Y. 
'''Proteomic Analysis of Human NK-92 Cells after NK Cell-Mediated Cytotoxicity against K562 Cells.''' 
Biochemistry (Mosc). 2007 Jul;72(7):716-27., [[PMID:17680763]]

Huntington ND. 
'''10th Meeting of the Society for Natural Immunity, Cambridge, UK, 11-14 April 2007.''' 
Immunol Cell Biol. 2007 Aug 7;. Epub, [[PMID:17680009]]

Goding SR, Yang Q, Knudsen KB, Potter DM, Basse PH. 
'''Cytokine Gene Therapy Using Adenovirally Transduced, Tumor-Seeking Activated Natural Killer Cells.''' 
Hum Gene Ther. 2007 Aug 3;. Epub, [[PMID:17678438]]

Guillard C, Zidi I, Marcou C, Menier C, Carosella ED, Moreau P. 
'''Role of HLA-G in innate immunity through direct activation of NF-kappaB in natural killer cells.''' 
Mol Immunol. 2007 Jul 31;. Epub, [[PMID:17675239]]

==August 6th, CiteTrack==
Plonquet, A, Haioun, C, Jais, J-P, Debard, A-L, Salles, G, Bene, M-C, Feugier, P, Rabian, C, Casasnovas, O, Labalette, M, Kuhlein, E, Farcet, J-P, Emile, J-F, Gisselbrecht, C, Delfau-Larue, M-H 
'''Peripheral blood natural killer cell count is associated with clinical outcome in patients with aaIPI 2 3 diffuse large B-cell lymphoma''' 
[http://annonc.oxfordjournals.org/cgi/content/abstract/18/7/1209?ct Ann Oncol 2007 18: p. 1209-1215]

==August 5th, PubCrawler==
Eagle RA, Trowsdale J. 
'''Promiscuity and the single receptor: [[NKG2D]].''' 
Nat Rev Immunol. 2007 Aug 3;. [[PMID:17673918]]

Savani BN, Mielke S, Adams S, Uribe M, Rezvani K, Yong AS, Zeilah J, Kurlander R, Srinivasan R, Childs R, Hensel N, Barrett AJ. 
'''Rapid natural killer cell recovery determines outcome after T-cell-depleted HLA-identical stem cell transplantation in patients with myeloid leukemias but not with acute lymphoblastic leukemia.''' 
Leukemia. 2007 Aug 2;. Epub, [[PMID:17673900]]

Tha-In T, Metselaar HJ, Tilanus HW, Groothuismink ZM, Kuipers EJ, de Man RA, Kwekkeboom J. 
'''Intravenous immunoglobulins suppress T-cell priming by modulating the bi-directional interaction between dendritic cells and natural killer cells.''' 
Blood. 2007 Aug 2;. Epub, [[PMID:17673603]]

Radaeva S, Wang L, Radaev S, Jeong WI, Park O, Gao B. 
'''Retinoic Acid Signaling Sensitizes Hepatic Stellate Cells to NK Cell Killing via Upregulation of NK Cell Activating Ligand RAE1.''' 
Am J Physiol Gastrointest Liver Physiol. 2007 Aug 2;. Epub, [[PMID:17673545]]

Rahman M, Nara H, Onoda T, Araki A, Li J, Hoshino T, Asao H. 
'''Cloning and characterization of an isoform of interleukin-21.''' 
FEBS Lett. 2007 Jul 25;. Epub, [[PMID:17673207]]

Owen RE, Yamada E, Thompson CI, Phillipson LJ, Thompson C, Taylor E, Zambon M, Osborn HM, Barclay WS, Borrow P. 
'''Alterations in receptor binding properties of recent human influenza H3N2 viruses are associated with reduced natural killer cell lysis of infected cells.''' 
J Virol. 2007 Aug 1;. Epub, [[PMID:17670834]]

van der Vliet HJ, Koon HB, Atkins MB, Balk SP, Exley MA. 
'''Exploiting Regulatory T-cell Populations for the Immunotherapy of Cancer.''' 
J Immunother (1997). 2007 Sep;30(6):591-595., [[PMID:17667522]]

Dorak MT. 
'''Role of natural killer cells and [[killer immunoglobulin-like receptor]] polymorphisms: association of HLA and [[KIR]]s.''' 
Methods Mol Med. 2007;134:123-44., [[PMID:17666748]]

Kloss S, Bochennek K, Huenecke S, Zimmermann SY, Kuci S, Muller T, Wels WS, Klingebiel T, Esser R, Koehl U. 
'''A novel five-colour flow cytometric assay to determine NK cell cytotoxicity against neuroblastoma and other adherent tumour cells.''' 
J Immunol Methods. 2007 Jul 16;. Epub, [[PMID:17663991]]

Montoya CJ, Pollard D, Martinson J, Kumari K, Wasserfall C, Mulder CB, Rugeles MT, Atkinson MA, Landay AL, Wilson SB. 
'''Characterization of human invariant natural killer T subsets in health and disease using a novel invariant natural killer T cell-clonotypic monoclonal antibody, [[6B11]].''' 
Immunology. 2007 Jul 28;. Epub, [[PMID:17662044]], NKref542

Wingender G, Kronenberg M. 
'''Invariant natural killer cells in the response to bacteria: the advent of specific antigens.''' 
Future Microbiol. 2006 Oct;1:325-340., [[PMID:17661645]]

==July 30st, PubCrawler==
Bottley G, Cook GP, Blair GE. 
'''A flow cytometric assay for analysis of natural-killer cell-mediated cytolysis of adenovirus-transformed cells.''' 
Methods Mol Med. 2007;131:221-30., [[PMID:17656786]]

Routes JM 
'''Measurement of natural-killer cell lytic activity of adenovirus-infected or adenovirus-transformed cells.''' 
Methods Mol Med. 2007;131:213-20., [[PMID:17656785]]

Tuckerman E, Laird SM, Prakash A, Li TC. 
'''Prognostic value of the measurement of uterine natural killer cells in the endometrium of women with recurrent miscarriage.''' 
Hum Reprod. 2007 Aug;22(8):2208-13., [[PMID:17656418]]

Rajalingam R. 
'''Killer Cell Immunoglobulin-Like Receptors Influence the Innate and Adaptive Immune Responses.''' 
Iran J Immunol. 2007 Jun;4(2):61-78., [[PMID:17652846]]

Omwandho CA, Peters C, Falconer J, Roberts TK, Tinneberg HR, Tumbo-Oeri AG. 
'''Ovine and Human Placental IgG inhibit Human Natural Killer Cell Cytotoxicity in vitro.''' 
Afr J Health Sci. 2001 Jan-Jun;8(1-2):47-54., [[PMID:17650047]]

Omwandho CA, Tumbo-Oeri AG, Tinneberg HR, Roberts TK, Falconer J. 
'''Immunological Role of the Placenta, Blocking Factors and NK Cells in Post-implantation Pregnancy.''' 
Afr J Health Sci. 2001 Jan-Jun;8(1-2):2-16., [[PMID:17650042]]

Luo L, Du Z, Sharma SK, Cullen R, Spellman S, Reed EF, Rajalingam R. 
'''Chain-terminating natural mutations affect the function of activating KIR receptors 3DS1 and 2DS3.''' 
Immunogenetics. 2007 Jul 24;. Epub, [[PMID:17646980]]

Wu HJ, Sawaya H, Binstadt B, Brickelmaier M, Blasius A, Gorelik L, Mahmood U, Weissleder R, Carulli J, Benoist C, Mathis D. 
'''Inflammatory arthritis can be reined in by CpG-induced DC NK cell cross talk.''' 
J Exp Med. 2007 Jul 23;. Epub, [[PMID:17646407]]

Korosec P, Osolnik K, Kern I, Silar M, Mohorcic K, Kosnik M. 
'''Expansion of Pulmonary CD8+CD56+ NKT Cells in Hypersensitivity Pneumonitis.''' 
Chest. 2007 Jul 23;. Epub. [[PMID:17646229]]

Kim N, Saudemont A, Webb L, Camps M, Ruckle T, Hirsch E, Turner M, Colucci F. 
'''The p110delta catalytic isoform of PI3K is a key player in NK cell development and cytokine secretion.''' 
Blood. 2007 Jul 20;. Epub, [[PMID:17644738]]

Macneil AJ, Pohajdak B. 
'''Polarization of endosomal SNX27 in migrating and tumor-engaged Natural Killer cells.''' 
Biochem Biophys Res Commun. 2007 Jul 16;. Epub, [[PMID:17644068]]

Spadaro M, Curcio C, Varadhachary A, Cavallo F, Engelmayer J, Blezinger P, Pericle F, Forni G. 
'''Requirement for IFN-gamma, CD8+ T lymphocytes, and NKT cells in talactoferrin-induced inhibition of neu+ tumors.''' 
Cancer Res. 2007 Jul 1;67(13):6425-32., [[PMID:17616703]]

==July 23rd, PubCrawler==
Stern-Ginossar N, Elefant N, Zimmermann A, Wolf DG, Saleh N, Biton M, Horwitz E, Prokocimer Z, Prichard M, Hahn G, Goldman-Wohl D, Greenfield C, Yagel S, Hengel H, Altuvia Y, Margalit H, Mandelboim O. 
'''Host Immune System Gene Targeting by a Viral miRNA.''' 
Science. 2007 Jul 20;317(5836):376-81., [[PMID:17641203]]

Pascal V, Yamada E, Martin MP, Alter G, Altfeld M, Metcalf JA, Baseler MW, Adelsberger JW, Carrington M, Anderson SK, McVicar DW. 
'''Detection of KIR3DS1 on the Cell Surface of Peripheral Blood NK Cells Facilitates Identification of a Novel Null Allele and Assessment of KIR3DS1 Expression during HIV-1 Infection.''' 
J Immunol. 2007 Aug 1;179(3):1625-33., [[PMID:17641029]]

Kawahara T, Rodriguez-Barbosa JI, Zhao Y, Zhao G, Sykes M. 
'''Global Unresponsiveness as a Mechanism of Natural Killer Cell Tolerance in Mixed Xenogeneic Chimeras.''' 
Am J Transplant. 2007 Jul 19;. Epub, [[PMID:17640313]]

Herington JL, Bany BM. 
'''The conceptus increases secreted phosphoprotein 1 gene expression in the mouse uterus during the progression of decidualization mainly due to its effects on uterine natural killer cells.''' 
Reproduction. 2007 Jun;133(6):1213-21., [[PMID:17636175]]

Sundstrom Y, Nilsson C, Lilja G, Karre K, Troye-Blomberg M, Berg L. 
'''The expression of human natural killer cell receptors in early life.''' 
Scand J Immunol. 2007 Aug;66(2-3):335-44., [[PMID:17635811]]

Wendt K, Wilk E, Buyny S, Schmidt RE, Jacobs R. 
'''Interleukin-21 differentially affects human natural killer cell subsets.''' 
Immunology. 2007 Jul 16;. Epub, [[PMID:17635612]]

Sandberg JK, Moll M. 
'''Effects of Interleukin-2 Treatment on CD1d-Restricted Natural Killer T Cells.''' 
Clin Cancer Res. 2007 Jul 15;13(14):4311., [[PMID:17634563]]

van der Vliet H, Koon H, Exley M. 
'''Effects of Interleukin-2 Treatment on CD1d-Restricted Natural Killer T Cells.''' 
Clin Cancer Res. 2007 Jul 15;13(14):4311., [[PMID:17634562]]

Beilke JN, Gill RG. 
'''Frontiers in Nephrology: The Varied Faces of Natural Killer Cells in Transplantation--Contributions to Both Allograft Immunity and Tolerance.''' 
J Am Soc Nephrol. 2007 Jul 18;. Epub, [[PMID:17634430]]

Bratke K, Julius P, Virchow JC. 
'''Invariant natural killer T cells in obstructive pulmonary diseases.''' 
N Engl J Med. 2007 Jul 12;357(2):194; author reply 194-5., [[PMID:17632897]]

Li S, Yan Y, Lin Y, Bullens DM, Rutgeerts O, Goebels J, Segers C, Boon L, Kasran A, De Vos R, Dewolf-Peeters C, Waer M, Billiau AD. 
'''Rapidly induced, T-independent xenoantibody production is mediated by marginal zone B cells and requires help from NK cells.''' 
Blood. 2007 Jul 13;. Epub, [[PMID:17630353]]

==July 20th, JI Cite Track==
'''Detection of KIR3DS1 on the Cell Surface of Peripheral Blood NK Cells Facilitates Identification of a Novel Null Allele and Assessment of KIR3DS1 Expression during HIV-1 Infection''' 
Pascal, V., Yamada, E., Martin, M. P., Alter, G., Altfeld, M., Metcalf, J. A., Baseler, M. W., Adelsberger, J. W., Carrington, M.,
Anderson, S. K., McVicar, D. W. 
http://www.jimmunol.org/cgi/content/abstract/179/3/1625?ct J Immunol 2007 179: p. 1625-1633

'''NK Cells Enhance Dendritic Cell Response against Parasite Antigens via NKG2D Pathway''' 
Guan, H., Moretto, M., Bzik, D. J., Gigley, J., Khan, I. A. 
http://www.jimmunol.org/cgi/content/abstract/179/1/590?ct J Immunol 2007 179: p. 590-596

'''Cutting Edge: Antioxidative Properties of Myeloid Dendritic Cells: Protection of T Cells and NK Cells from Oxygen Radical-Induced Inactivation and Apoptosis''' 
Thoren, F. B., Betten, A., Romero, A. I., Hellstrand, K. 
http://www.jimmunol.org/cgi/content/abstract/179/1/21?ct J Immunol 2007 179: p. 21-25

'''Single-Stranded RNA Derived from HIV-1 Serves as a Potent Activator of NK Cells''' 
Alter, G., Suscovich, T. J., Teigen, N., Meier, A., Streeck, H., Brander, C., Altfeld, M. 
http://www.jimmunol.org/cgi/content/abstract/178/12/7658?ct J Immunol 2007 178: p. 7658-7666

'''Intercellular protein transfer at the NK cell immune synapse: mechanisms and physiological significance''' 
Roda-Navarro, P., Reyburn, H. T. 
http://www.fasebj.org/cgi/content/abstract/21/8/1636?ct FASEB J. 2007 21: p. 1636-1646

'''Distinctive NK-cell receptor repertoires sustain high-level constitutive NK-cell activation in HIV-exposed uninfected individuals''' 
Ravet, S., Scott-Algara, D., Bonnet, E., Tran, H. K., Tran, T., Nguyen, N., Truong, L. X., Theodorou, I., Barre-Sinoussi, F., Pancino, G., Paul, P.
http://bloodjournal.hematologylibrary.org/cgi/content/abstract/109/10/4296?ct Blood 2007 109: p. 4296-4305

==July 15th, PubCrawler==
Shinagawa N, Yamazaki K, Tamura Y, Imai A, Kikuchi E, Yokouchi H, Hommura F, Oizumi S, Nishimura M. 
'''Immunotherapy with dendritic cells pulsed with tumor-derived gp96 against murine lung cancer is effective through immune response of '''CD8(+) cytotoxic T lymphocytes and natural killer cells.''' 
Cancer Immunol Immunother. 2007 Jul 13;. Epub, [[PMID:17628800]]

Titanji K, Sammicheli S, De Milito A, Mantagani P, Fortis C, Berg L, Karre K, Travi G, Tassandin C, Lopalco L, Rethi B, Tambussi G, Chiodi F. 
'''Altered distribution of natural killer cell subsets identified by CD56, CD27 and CD70 in primary and chronic human immunodeficiency virus-1 infection.''' 
Immunology. 2007 Jul 11;. Epub, [[PMID:17627773]]

Neill M, Dixon PS. 
'''Effects of a preincisional 14-day course of valerian on natural killer cell activity in sprague-dawley male rats undergoing abdominal surgery.''' 
Holist Nurs Pract. 2007 Jul-Aug;21(4):187-93., [[PMID:17627197]]

Zhang AL, Colmenero P, Purath U, Teixeira de Matos C, Hueber W, Klareskog L, Tarner IH, Engleman EG, Soderstrom K. 
'''Natural killer cells trigger differentiation of monocytes into dendritic cells.''' 
Blood. 2007 Jul 12;. Epub, [[PMID:17626840]]

Heron M, Claessen AM, Grutters JC. 
'''Invariant natural killer T cells in obstructive pulmonary diseases.''' 
N Engl J Med. 2007 Jul 12;357(2):194; author reply 194-5., [[PMID:17626309]]

Chen Y, Wei H, Sun R, Dong Z, Zhang J, Tian Z. 
'''Increased susceptibility to liver injury in hepatitis B virus transgenic mice involves NKG2D-ligand interaction and natural killer cells.''' 
Hepatology. 2007 Jul 11;. Epub, [[PMID:17626270]]

Kato N, Tanaka J, Sugita J, Toubai T, Miura Y, Ibata M, Syono Y, Ota S, Kondo T, Asaka M, Imamura M. 
'''Regulation of the expression of MHC class I-related chain A, B (MICA, MICB) via chromatin remodeling and its impact on the susceptibility of leukemic cells to the cytotoxicity of NKG2D-expressing cells.''' 
Leukemia. 2007 Jul 12;. [Epub ahead of print]
PMID: 17625602 [PubMed - as supplied by publisher]

Akbari O, Faul JL, Umetsu DT. 
'''Invariant natural killer T cells in obstructive pulmonary diseases.''' 
N Engl J Med. 2007 Jul 12;357(2):193-4; author reply 194-5., [[PMID:17625134]]

Dybkaer K, Iqbal J, Zhou G, Geng H, Xiao L, Schmitz A, D' Amore F, Chan WC. 
'''Genome wide transcriptional analysis of resting and IL2 activated human natural killer cells: gene expression signatures indicative of novel molecular signaling pathways.''' 
BMC Genomics. 2007 Jul 10;8(1):230. Epub, [[PMID:17623099]]

Zhang J, Tian Z. 
'''UNK cells: their role in tissue re-modelling and preeclampsia.''' 
Semin Immunopathol. 2007 Jun;29(2):123-33., [[PMID:17621698]]

Saito S, Shiozaki A, Sasaki Y, Nakashima A, Shima T, Ito M. 
'''Regulatory T cells and regulatory natural killer (NK) cells play important roles in feto-maternal tolerance.''' 
Semin Immunopathol. 2007 Jun;29(2):115-22., [[PMID:17621697]]

Huntington ND, Puthalakath H, Gunn P, Naik E, Michalak EM, Smyth MJ, Tabarias H, Degli-Esposti MA, Dewson G, Willis SN, Motoyama N, Huang DC, Nutt SL, Tarlinton DM, Strasser A. 
'''Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1.''' 
Nat Immunol. 2007 Jul 8;. Epub, [[PMID:17618288]]

Hamby K, Trexler A, Pearson TC, Larsen CP, Rigby MR, Kean LS. 
'''NK Cells Rapidly Reject Allogeneic Bone Marrow in the Spleen Through a Perforin- and Ly49D-Dependent, but NKG2D-Independent Mechanism.''' 
Am J Transplant. 2007 Aug;7(8):1884-96., [[PMID:17617852]]

Kim GG, Donnenberg VS, Donnenberg AD, Gooding W, Whiteside TL. 
'''A novel multiparametric flow cytometry-based cytotoxicity assay simultaneously immunophenotypes effector cells: Comparisons to a 4 h (51)Cr-release assay.''' 
J Immunol Methods. 2007 Jun 28;. Epub, [[PMID:17617419]]

Wang S, Zhao YR, Jiao YL, Wang LC, Li JF, Cui B, Xu CY, Shi YH, Chen ZJ. 
'''Increased activating killer immunoglobulin-like receptor genes and decreased specific HLA-C alleles in couples with recurrent spontaneous abortion.''' 
Biochem Biophys Res Commun. 2007 Jul 2;. Epub, [[PMID:17617375]]

Gigli G, Caielli S, Cutuli D, Falcone M. 
'''Innate immunity modulates autoimmunity: type 1 interferon-beta treatment in multiple sclerosis promotes growth and function of regulatory invariant natural killer T cells through dendritic cell maturation.''' 
Immunology. 2007 Jul 6;. Epub, [[PMID:17617156]]

Belisle JA, Gubbels JA, Raphael CA, Migneault M, Rancourt C, Connor JP, Patankar MS. 
'''Peritoneal natural killer cells from epithelial ovarian cancer patients show an altered phenotype and bind to the tumour marker MUC16 (CA125).''' 
Immunology. 2007 Jul 6;. Epub, [[PMID:17617155]]

Chaouat G. 
'''The Th1/Th2 paradigm: still important in pregnancy?''' 
Semin Immunopathol. 2007 Jun;29(2):95-113., [[PMID:17626305]]

==July 9th, PubCrawler==
Mistry AR, O'callaghan CA. 
'''Regulation of ligands for the activating receptor NKG2D.''' 
Immunology. 2007 Aug;121(4):439-47., [[PMID:17614877]]

Fujibayashi Y, Fujimori Y, Kasumoto I, Kai S, Hara H, Okamura H, Tsutsui H, Ogawa H, Nakanishi K. 
'''Interleukin-18 regulates T helper 1 or 2 immune responses of human cord blood CD4+ Valpha24+Vbeta11+ natural killer T cells.''' 
Int J Mol Med. 2007 Aug;20(2):241-5., [[PMID:17611643]]

O'connor GM, Holmes A, Mulcahy F, Gardiner CM. 
'''Natural Killer cells from long-term non-progressor HIV patients are characterized by altered phenotype and function.''' 
Clin Immunol. 2007 Jul 2;. Epub, [[PMID:17611161]]

Garrod KR, Wei SH, Parker I, Cahalan MD. 
'''Natural killer cells actively patrol peripheral lymph nodes forming stable conjugates to eliminate MHC-mismatched targets.''' 
Proc Natl Acad Sci U S A. 2007 Jul 3;. Epub, [[PMID:17609379]]

Banerjee P, Feuer G, Barker E. 
'''HTLV-1 p12I down-modulates ICAM-1 and -2 and reduces natural killer cell adherence thereby protecting HTLV-1-infected primary CD4+ T cells from autologous natural killer cell-mediated cytotoxicity despite the reduction of major histocompatibility complex class I molecules on the infected cells.''' 
J Virol. 2007 Jul 3;. Epub, [[PMID:17609265]]

Nakamura I, Ochiai K, Imai Y, Moriyasu F, Imawari M. 
'''Restoration of innate host defense responses by oral supplementation of branched-chain amino acids in decompensated cirrhotic patients.''' 
Hepatol Res. 2007 Jul 1;. Epub, [[PMID:17608669]]

Xia C, Schumann J, Emmanuel R, Zhang Y, Chen W, Zhang W, Libero GD, Wang PG. 
'''Modification of the Ceramide Moiety of Isoglobotrihexosylceramide on Its Agonist Activity in Stimulation of Invariant Natural Killer T Cells.''' 
J Med Chem. 2007 Jul 4;. Epub, [[PMID:17608465]]

Yang L, Jhaveri R, Huang J, Qi Y, Diehl AM. 
'''Endoplasmic reticulum stress, hepatocyte CD1d and NKT cell abnormalities in murine fatty livers.''' 
Lab Invest. 2007 Jul 2;. Epub, [[PMID:17607300]]

Williams GS, Collinson LM, Brzostek J, Eissmann P, Almeida CR, McCann FE, Burshtyn D, Davis DM. 
'''Membranous Structures Transfer Cell Surface Proteins Across NK Cell Immune Synapses.''' 
Traffic. 2007 Jul 1;. Epub, [[PMID:17605758]]

Peralbo E, Alonso C, Solana R. 
'''Invariant NKT and NKT-like lymphocytes: Two different T cell subsets that are differentially affected by ageing.''' 
Exp Gerontol. 2007 May 21;. Epub, [[PMID:17604928]]

French AR, Kim S, Fehniger TA, Pratt JR, Yang L, Song YJ, Caligiuri MA, Yokoyama WM. 
'''Chronic lymphocytosis of functionally immature natural killer cells.''' 
J Allergy Clin Immunol. 2007 Jun 28;. Epub, [[PMID:17604094]]

Saraste M, Irjala H, Airas L. 
'''Expansion of CD56(Bright) natural killer cells in the peripheral blood of multiple sclerosis patients treated with interferon-beta.''' 
Neurol Sci. 2007 Jun;28(3):121-6., [[PMID:17603762]]

==July 2nd, PubCrawler & JI Cite Track==
Cerboni, C., Zingoni, A., Cippitelli, M., Piccoli, M., Frati, L., Santoni, A. 
'''Antigen-activated human T lymphocytes express cell-surface NKG2D ligands via an ATM/ATR-dependent mechanism and become susceptible to autologous NK-cell lysis''' 
[http://bloodjournal.hematologylibrary.org/cgi/content/abstract/110/2/606?ctÂ¡ Blood 2007 110: p. 606-615]

Wu L, Van Kaer L. 
'''NKT cells and diabetes.''' 
Am J Physiol Gastrointest Liver Physiol. 2007 Jun 28;. Epub, [[PMID:17600041]]

Veldt BJ, van der Vliet HJ, von Blomberg BM, van Vlierberghe H, Gerken G, Nishi N, Hayashi K, Scheper RJ, de Knegt RJ, van den Eertwegh AJ, Janssen HL, van Nieuwkerk CM. 
'''Randomized placebo controlled phase I/II trial of alpha-galactosylceramide for the treatment of chronic hepatitis C.''' 
J Hepatol. 2007 Jun 6;. Epub, [[PMID:17599630]]

Ren XB, Yu JP, Cao S, Ren BZ, Li H, Liu H, Min WP, Hao XS. 
'''Antitumor Effect of Large Doses IL-2-Activated HLA Haploidentical Peripheral Blood Stem Cells on Refractory Metastatic Solid Tumor Treatment.''' 
Cancer Biother Radiopharm. 2007 Apr;22(2):223-34., [[PMID:17600469]]

Shibata F, Toma T, Wada T, Inoue M, Tone Y, Ohta K, Kasahara Y, Sano F, Kimura M, Ikeno M, Koizumi S, Yachie A. 
'''Skin infiltration of CD56(bright) CD16(-) natural killer cells in a case of X-SCID with Omenn syndrome-like manifestations.''' 
Eur J Haematol. 2007 Jul;79(1):81-5., [[PMID:17598841]]

Prolo P, Chiappelli F, Angeli A, Dovio A, Perotti P, Pautasso M, Sartori ML, Saba L, Mussino S, Fraccalini T, Fanto F, Mocellini C, Rosso MG, Grasso E. 
'''Physiologic modulation of natural killer cell activity as an index of Alzheimer's disease progression.''' 
Bioinformation. 2007 Mar 21;1(9):363-6., [[PMID:17597922]]

Sprangers B, Van Wijmeersch B, Fevery S, Waer M, Billiau AD. 
'''Experimental and clinical approaches for optimization of the graft-versus-leukemia effect.''' 
Nat Clin Pract Oncol. 2007 Jul;4(7):404-14., [[PMID:17597705]]

Alkim H, Unal S, Okur H, Imir T. 
'''Omeprazole Inhibits Natural Killer Cell Functions.''' 
Dig Dis Sci. 2007 Jun 28;. Epub, [[PMID:17597410]]

Meyer EH, DeKruyff RH, Umetsu DT. 
'''iNKT cells in allergic disease.''' 
Curr Top Microbiol Immunol. 2007;314:269-91., [[PMID:17593665]]

Miyake S, Yamamura T. 
'''NKT cells and autoimmune diseases: unraveling the complexity.''' 
Curr Top Microbiol Immunol. 2007;314:251-67., [[PMID:17593664]]

MacDonald HR, Mycko MP. 
'''Development and selection of Valpha l4i NKT cells.''' 
Curr Top Microbiol Immunol. 2007;314:195-212., [[PMID:17593662]]

Naoe M, Ogawa Y, Takeshita K, Morita J, Iwamoto S, Miyazaki A, Yoshida H. 
'''Bacillus Calmette-Guerin-pulsed dendritic cells stimulate natural killer T cells and gammadeltaT cells.''' 
Int J Urol. 2007 Jun;14(6):532-8., [[PMID:17593099]]

Godfrey DI, Berzins SP. 
'''Control points in NKT-cell development.''' 
Nat Rev Immunol. 2007 Jul;7(7):505-18., [[PMID:17589542]]

Sivula J, Volin L, Porkka K, Vettenranta K, Itala M, Partanen J, Turpeinen H. 
'''Killer-cell immunoglobulin-like receptor ligand compatibility in the outcome of Finnish unrelated donor hematopoietic stem cell transplantation.''' 
Transpl Immunol. 2007 Jul;18(1):62-6., [[PMID:17584604]]

Chung Y, Qin H, Kang CY, Kim S, Kwak LW, Dong C. 
'''An NKT-mediated autologous vaccine generates CD4 T cell-dependent potent anti-lymphoma immunity.''' 
Blood. 2007 Jun 20;. Epub, [[PMID:17581919]]

Borg NA, Wun KS, Kjer-Nielsen L, Wilce MC, Pellicci DG, Koh R, Besra GS, Bharadwaj M, Godfrey DI, McCluskey J, Rossjohn J. 
'''CD1d-lipid-antigen recognition by the semi-invariant NKT T-cell receptor.''' 
Nature. 2007 Jun 20;. Epub, [[PMID:17581592]]

Pfister K, Radons J, Busch R, Tidball JG, Pfeifer M, Freitag L, Feldmann HJ, Milani V, Issels R, Multhoff G. 
'''Patient survival by Hsp70 membrane phenotype : association with different routes of metastasis.''' 
Cancer. 2007 Jun 19;. Epub, [[PMID:17580361]]

Sforcin JM. 
'''Propolis and the immune system: a review.''' 
J Ethnopharmacol. 2007 May 22;. Epub, [[PMID:17580109]]

Wittnebel S, Da Rocha S, Giron-Michel J, Jalil A, Opolon P, Escudier B, Validire P, Khawam K, Chouaib S, Azzarone B, Caignard A. 
'''Membrane-Bound Interleukin (IL)-15 on Renal Tumor Cells Rescues Natural Killer Cells from IL-2 Starvation-Induced Apoptosis.''' 
Cancer Res. 2007 Jun 15;67(12):5594-9., [[PMID:17575122]]

Allez M, Tieng V, Nakazawa A, Treton X, Pacault V, Dulphy N, Caillat-Zucman S, Paul P, Gornet JM, Douay C, Ravet S, Tamouza R, Charron D, Lemann M, Mayer L, Toubert A 
'''CD4+NKG2D+ T cells in Crohn's disease mediate inflammatory and cytotoxic responses through MICA interactions.''' 
Gastroenterology. 2007 Jun;132(7):2346-58. Epub 2007 Mar 16., [[PMID:17570210]]

Estefania E, Gomez-Lozano N, Portero F, de Pablo R, Solis R, Sepulveda S, Vaquero M, Gonzalez MA, Suarez E, Roustan G, Vilches C 
'''Influence of KIR gene diversity on the course of HSV-1 infection: resistance to the disease is associated with the absence of KIR2DL2 and KIR2DS2.''' 
Tissue Antigens. 2007 Jul;70(1):34-41., [[PMID:17559579]]

Tamaki S, Sanefuzi N, Ohgi K, Imai Y, Kawakami M, Yamamoto K, Ishitani A, Hatake K, Kirita T 
'''An association between the MICA-A5.1 allele and an increased susceptibility to oral squamous cell carcinoma in Japanese patients.''' 
J Oral Pathol Med. 2007 Jul;36(6):351-6., [[PMID:17559497]]

==Quarterly Archive of [[NK Journal Screening]] Results==
{{NK Papers Archive}}
----

De:Pattern-recognition receptor

Volker Huppert — Wed, 09 Jan 2008 01:07:02 GMT

Summary:

Unter dem Begriff '''''pattern-recognition receptors''''' (PRRs, Ã¼bersetzt etwa "mustererkennende Rezeptoren") werden eine Vielzahl unterschiedlicher Proteine zusammengefasst, die Pathogene anhand von charakteristischen Mustern (siehe [[PAMP | ''pathogen-associated molecular patterns'']], PAMPs) erkennen und so wesentlich an der Einleitung einer [[Immunantwort]] beteiligt sind. Einige PRRs kommen frei lÃ¶slich im Blut vor, die meisten sind jedoch an die OberflÃ¤che von Immunzellen gebunden oder finden sich in deren Zellinneren. PRRs auf der ZelloberflÃ¤che kÃ¶nnen die [[Phagozytose]] von Pathogenen ermÃ¶glichen oder aktivierende Signale in die Zelle weiterleiten. Die Aktivierung der Immunzellen ist auch die Hauptfunktion aller intrazellulÃ¤ren PRRs. Immunzellen kÃ¶nnen auf diese Aktivierung auf vielfÃ¤ltige Weise reagieren, etwa durch Freisetzung von lÃ¶slichen VerteidigungsmolekÃ¼len, durch AbtÃ¶ten von infizierten Zellen oder durch eine verbesserte FÃ¤higkeit zur [[AntigenprÃ¤sentation]]. Aufgrund struktureller Ã„hnlichkeiten werden die zellgebundenen PRRs in mehrere Rezeptorfamilien unterteilt.

==LÃ¶sliche PRRs==
Ein gut untersuchter lÃ¶slicher PRR ist das Mannose-bindende Lektin, welches an ZuckermolekÃ¼le bindet, wenn diese in einer bestimmten Anordnung auf der OberflÃ¤che von Mikroorganismen vorkommen. Diese Bindung lÃ¶st die [[ Komplementsystem | Komplement-Kaskade]] aus, wodurch der Erreger letztendlich unschÃ¤dlich gemacht wird.

==OberflÃ¤chen-PRRs==
===Scavenger-Rezeptoren===
Die Scavenger-Rezeptoren (''scavenger'' [engl.] = StraÃŸenfeger) ermÃ¶glichen Fresszellen die Phagozytose von Pathogenen. Insgesamt wurden mindestens neun unterschiedliche Rezeptoren nachgewiesen, die auf Grund von Strukturmerkmalen in unterschiedliche Klassen (SR-A, -B, -C usw.) aufgeteilt werden. SR-A1 kommt vor allem in Makrophagen vor und bindet an unterschiedlichste polyanionische Liganden, was u.a. die Aufnahme von Bakterien (sowohl Gram-positiv als auch â€“negativ) und toten Zellen ermÃ¶glicht. Die Bedeutung dieses Rezeptors wird dadurch unterstrichen, dass zumindest in MÃ¤usen bei Abwesenheit von SR-A bestimmte Bakterien nicht mehr wirksam abgewehrt werden kÃ¶nnen.

===C-Typ Lektin-Rezeptoren===
Diese Rezeptoren sind ebenfalls an der Phagozytose von Pathogenen beteiligt. Die Bindung an unterschiedlichste Erreger wie Bakterien, Viren, Pilze und Parasiten erfolgt Ã¼ber eine Calcium-abhÃ¤ngige Erkennung von typischen Zuckerverbindungen. Zu den ungefÃ¤hr 10 verschiedenen Mitgliedern dieser Familie zÃ¤hlt auch der Mannose-Rezeptor der Makrophagen, der Erreger auf eine Ã¤hnliche Weise erkennt wie das Mannose-bindende Lektin.

===''Toll-like receptors'' (TLRs)===
:Siehe auch den [[Toll-like_Receptor|Hauptartikel ''Toll-like receptor'']].
TLRs erkennen unterschiedlichste Bestandteile von Bakterien, Viren, Pilze und Protozoen und lÃ¶sen eine starke Aktivierung der Immunzellen aus, u.a. Ã¼ber den Transkriptionsfaktor [[NF-kB|NF- ÎºB]]. Alle 11 Mitglieder dieser Familie sind Bestandteile der Zellmembran, manche sind aber nicht auf der ZelloberflÃ¤che sondern befinden sich in intrazellulÃ¤ren Organellen.

==IntrazellulÃ¤re PRRs==
===''NOD-like receptors'' (NLRs)===
Von den mehr als 23 Varianten im humanen Genom sind nur wenige gut untersucht. Diese erkennen Bakterien und rufen eine Aktivierung der Immunzellen durch Mobilisierung des Transkriptionsfaktors NF-kB und dem [[Interleukin-1]]-aktivierenden Enzym Caspase-1 hervor. Diese Rezeptorfamilie weist strukturelle Ã„hnlichkeiten mit einer Klasse von Abwehrstoffen in Pflanzen auf, den R-Proteinen.

===RIG-I-Ã¤hnliche Proteine===
Die drei bisher bekannten Mitglieder dieser Familie (darunter das namensgebende [[RIG-I]]) haben eine [[Helikase|RNA-Helikase]]-AktivitÃ¤t und sind an der Erkennung von Viren beteiligt. Sie lÃ¶sen eine Aktivierung von Immunzellen durch die Transkriptionsfaktoren der IRF-Familie und NF-kB aus.

==Literatur==

* Charles A. Janeway, Paul Travers, Mark Walport: ''Immunobiology''. B&T; 6. Auflage (2005) ISBN 0815341016
* L. Peiser et al.: ''Scavenger receptors in innate immunity''. In: ''Curr.Opin.Immunol''. Bd. 14, Nr. 1, 2002, S. 123-128. [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&query_hl=1&itool=pubmed_docsum&list_uids=11790542 Abstract]
* E. P. McGreal et al.: ''Ligand recognition by antigen-presenting cell C-type lectin receptors''. In: ''Curr.Opin.Immunol''. Bd. 17, Nr. 1, 2005, S. 18-24. [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&query_hl=1&itool=pubmed_docsum&list_uids=15653305 Abstract]
* E. M. Creagh et al.: ''TLRs, NLRs and RLRs: a trinity of pathogen sensors that co-operate in innate immunity''. In: ''Trends Immunol''. Bd. 27, Nr. 8, 2006, S. 352-357. [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&query_hl=1&itool=pubmed_docsum&list_uids=16807108 Abstract]
* F. Martinon et al.: ''NLRs join TLRs as innate sensors of pathogens''. In: ''Trends Immunol''. Bd. 26, Nr. 8, 2005, S. 447-454. [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&query_hl=1&itool=pubmed_docsum&list_uids=15967716 Abstract]
* E. Meylan et al.: ''Intracellular pattern recognition receptors in the host response''. In: ''Nature''. Bd. 442, Nr. 7098, 2006, S. 39-44. [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&query_hl=1&itool=pubmed_docsum&list_uids=16823444 Abstract]

[[Kategorie:Immunologie]]

Pattern recognition receptor

Volker Huppert — Wed, 09 Jan 2008 01:05:27 GMT

Summary:

'''Pattern recognition receptors''', or '''PRR'''s, are [[protein]]s expressed by cells of the [[immune system]] to identify molecules associated with microbial [[pathogens]] or cellular stress.

==Molecules recognized==
The microbe-specific molecules that are recognized by a given PRR are called PAMPs: [[pathogen-associated molecular pattern]]s and include bacterial carbohydrates (e.g. [[lipopolysaccharide]] or LPS, [[mannose]]), nucleic acids (e.g. bacterial or viral DNA or RNA), [[peptidoglycan]]s and [[lipotechoic acid]]s (from Gram positive bacteria), [[N-Formylmethionine|''N''-formylmethionine]], [[lipoprotein]]s and fungal [[glucan]]s.

Endogenous stress signals are called DAMPs ([[danger-associated molecular pattern]]s) and include [[uric acid]].

==Classification==
PRRs are classified according to their [[ligand]] specificity, function, localization and/or evolutionary relationships. On the basis of function, PRRs may divided into endocytic PRRs or signaling PRRs.

* ''Signaling PRRs'' include the large families of membrane-bound [[Toll-like receptors]] and cytoplasmic NOD-like receptors.

* ''Endocytic PRRs'' promote the attachment, engulfment and destruction of microorganisms by phagocytes, without relaying an intracellular signal. These PRRs recognize carbohydrates and include mannose receptors of [[macrophage]]s, [[glucan]] receptors present on all [[phagocytes]] and [[scavenger receptor]]s that recognize charged ligands, are found on all phagocytes and mediate removal of apoptotic cells.

==Types==
===Membrane-bound PRRs===
====Toll-like receptors====
Recognition of extracellular or endosomal pathogen-associated molecular patterns is mediated by an array of transmembrane proteins known as [[toll-like receptor]]s (TLRs).<ref>Beutler et al. GENETIC ANALYSIS OF HOST RESISTANCE: Toll-Like Receptor Signaling and Immunity at Large. Annual Review of Immunology Volume 24, pages 353-389.</ref> Toll-like receptors were first discovered in ''[[Drosophila melanogaster|Drosophila]]'' and are known to trigger a series of mechanisms leading to the synthesis and secretion of cytokines and activation other host defense programs that are crucial to the development of innate or adaptative immune responses. At present, TLRs have been found in many species. In mammals, these receptors have been assigned numbers 1 to 11 (TLR1-TLR11). Interaction of TLRs with their specific PAMP induces [[NFkB|NFÎºB]] signaling and [[Mitogen-activated protein kinase|MAP kinase]] pathway and therefore the secretion of pro-inflammatory [[cytokine]]s and [[co-stimulation|co-stimulatory molecule]]s. Molecules released following TLR activation signal to other cells of the immune system making TLRs key elements of [[innate immunity]] and [[adaptive immunity]].<ref>Doyle and O'Neill. Toll-like receptors: From the discovery of NFÎºB to new insights into transcriptional regulations in innate immunity. Biochemical Pharmacology Volume 72, Issue 9 , 2006, Pages 1102-1113.
</ref>

====The mannose receptor====
The [[mannose receptor]] (MR) is a PRR primarily present on the surface of [[macrophage]]s and [[dendritic cell]]s. It recognizes and binds to carbohydrates on the surfaces of infectious agents and its activation triggers endocytosis and phagocytosis of the microbe. The MR belongs to the multilectin receptor protein group and, like the TLRs, provides a link between innate and adaptive immunity.<ref>Apostolopoulos and McKenzie. Role of the Mannose Receptor in the Immune Response. Current Molecular Medicine 2001, Volume 1, pages 469-474.</ref>

===Cytoplasmic PRRs===
====NOD Like Receptors====
The NOD-like receptors (NLRs) are cytoplasmic proteins that may have a variety of functions in regulation of inflammatory and apoptotic responses. Approximately 20 of these proteins have been found in the mammalian genome and include two major subfamilies called NODs and NALPs, the [[MHC Class II]] transactivator ([[CIITA]]), and some other molecules (e.g. IPAF and BIRC1). Current understanding suggests some of these proteins recognize endogenous or microbial molecules or stress responses and form oligomers that activate inflammatory caspases (e.g. [[caspase 1]]) causing cleavage and activation of important inflammatory [[cytokine]]s such as [[IL-1]], and/or activate the [[NF-ÎºB]] signaling pathway to induce production of inflammatory molecules. The NLR family is known under several different names, including the CATERPILLER (or CLR) or NOD-LRR family.<ref>Ting JP, Williams KL. The CATERPILLER family: an ancient family of immune/apoptotic proteins. Clinical Immunology, 2005, Volume 115(1):33-7.</ref><ref>Harton JA et al., CATERPILLER: a large family of mammalian genes containing CARD, pyrin, nucleotide-binding, and leucine-rich repeat domains. J Immunol. 2002 Volume 169(8):4088-93.</ref><ref>Inohara et al., NOD-LRR proteins: role in host-microbial interactions and inflammatory disease. Annu Rev Biochem. 2005, Volume 74:355-83.</ref>

:;NODS
::The ligands are currently known for [[NOD1]] and [[NOD2]]. NOD1 recognizes a molecule called meso-DAP, that is a [[peptidoglycan]] constituent of only [[Gram negative]] bacteria. NOD2 proteins recognize intracellular MDP (muramyl dipeptide), which is a peptidoglycan constituent of both Gram positive and Gram negative bacteria. NODS transduce signals in the pathway of [[NF-ÎºB]] and [[MAP kinase]]s via the [[serine-threonine kinase]] called RIP2. NOD proteins are so named as they contain a [[nucleotide-binding oligomerization domain]] which binds [[nucleotide]] triphosphate. NODs signal via N-terminal [[CARD domain]]s to activate downstream gene induction events, and interact with microbial molecules by means of a [[C-terminal]] [[leucine-rich repeat]] (LRR) region.<ref>Strober et al., Signalling pathways and molecular interactions of NOD1 and NOD2. Nat Rev Immunol. 2006, Volume 6(1):9-20.</ref>

:;NALPS
::Like NODs, these proteins contain C-terminal LRRs, which appear to act as a regulatory domain and may be involved in the recognition of microbial pathogens. Also like NODs, these proteins also contain a nucleotide binding site (NBS) for nucleotide triphosphates. Interaction with other proteins (e.g. the adaptor molecule ASC) is mediated via N-terminal pyrin (PYD) domain. There are 14 members of this subfamily in humans (called NALP1 to NALP14). Mutations in NALP3 are responsible for the autoinflammatory diseases [[familial cold autoinflammatory syndrome]], [[Muckle-Wells syndrome]] and [[neonatal onset multisystem inflammatory disease]]. Activators of NALP3 include [[muramyl dipeptide]], bacterial DNA, [[Adenosine triphosphate|ATP]], toxins, double stranded [[RNA]], [[paramyxovirus]]es and [[uric acid]] crystals. Although these specific molecules have been shown to activate NALP3, it remains unclear whether this is due to direct binding or due to cellular stress induced by these agents.

:;Other NLRs
::Other NLRs such as Ipaf and NAIP5/Birc1e have also been shown to activate caspase-1 in response to [[Salmonella]] and [[Legionella]].

====RNA Helicases====
Intracellular recognition of viral double-stranded (ds) and single stranded [[RNA]] has been shown to be mediated by a group of [[RNA Helicase]]s which in turn recruit factors via twin N-terminal [[CARD domain]]s to activate antiviral gene programs. Three such helicases have been described in mammals--RIG-I and MDA5 (recognizing 5'triphosphate-RNA and dsRNA, respectively), which activate antiviral signaling , and LGP2, which appears to act as a [[dominant-negative]] inhibitor.

<gallery>
Image:Simon (RIG-I and Mda5).jpg|RIG-I and Mda5-mediated signalling pathway.

</gallery>

====Plant R Proteins====
Plants contain a significant number of PRRs that share remarkable structural and functional similarity with those found in higher organisms such as drosophila and mammals. As can be predicted, these proteins activate host defense mechanisms in response to infection. Several characterized proteins feature NBS and LRR domains, as well as some conserved interaction domains such as the TIR. As in mammalian systems, controversy exists as to whether R proteins recognize discreet ligands via their LRRs, are activated by cellular stress, or a combination of the two.

===Secreted PRRs===
A number of PRRs do not remain associated with the cell that produces them. [[Complement (biology)|Complement receptor]]s, [[collectin]]s, [[pentraxin]] proteins such as serum [[amyloid]] and [[C-reactive protein]], [[lipid transferase]]s and [[peptidoglycan recognition protein]]s (PGRs) are all secreted proteins. One very important collectin is [[mannan-binding lectin]] (MBL), a major PRR of the innate immune system that binds to a wide range of bacteria, viruses, fungi and protozoa. MBL predominantly recognizes certain sugar groups on the surface of microorganisms but also binds [[phospholipid]]s, [[nucleic acid]]s and non-[[glycosylation|glycosylated]] proteins.<ref>Dommett et al., Mannose-binding lectin in innate immunity: past, present and future. Tissue Antigens, 2006, Volume 68 Issue 3 Page 193</ref>



==External links==




[[Category:Immune system]]

[[de:Pattern-recognition receptor]]

CLEC2A

Volker Huppert — Fri, 14 Dec 2007 01:36:43 GMT

Summary:

==References==
Spreu J, Kienle EC, Schrage B, Steinle A. 
'''[[CLEC2A]]: a novel, alternatively spliced and skin-associated member of the NKC-encoded [[AICL]]-CD69-LLT1 family.''' 
Immunogenetics. 2007 Nov 29;. Epub, [[PMID:18046548]]

==Weblinks==
[http://harvester.fzk.de/harvester/human/IPI00398/IPI00398946.htm CLEC2A @ KIT Bioinformatics Harvester]

NK cell protocols

Volker Huppert — Sun, 04 Nov 2007 21:01:37 GMT

Summary:

==Further Reading==
* [[NK cell activation]]
* [[NK cell expansion]]
* [[NK cell therapy]]

==References==

==WebLinks==
* [http://www.openwetware.org OpenWetWare.org]