NK cell subsets

From NKcells.info

Contents 1 Introduction 2 Further Reading 3 References 3.1 References CD56- 3.2 References CD56bright / CD56dim 3.3 References CD8+/- NK cells 3.4 References murine B220+CD11c+NK1.1+ NK cells 3.5 References for additional NK cell subsets

Introduction

Initially Natural Killer Cells have been regarded as a uniform subset of peripheral blood lymphocytes. During the past years at least the following NK cell subsets have been described.

• CD56dimCD3- NK cells
  • sometimes referred to as cytotoxic NK cells
  • mainly CD16+panKIR+NKp46+
• CD56brightCD3- NK cells
  • sometime referred to as regulatory NK cells or cytokine secreting NK cells
  • CD16-NKp46+
• CD56-CD161+CD3- NK cells
• CD56-CD16+ NK cells
  • Mavilio et al., PNAS 2005, PMID: 15699323
• NK helper cells CD56(+)/CD83(+)/CCR7(+)/CD25(+)
• decidual NK cells
• murine B220+CD11c+NK1.1+ cells
  • Blasius AL et al., J Exp Med. 2007 Oct 8;. Epub, PMID:17923504
• additional subsets with significant overlap with each other
  • CD56+CD3-CD8- NK cells
  • CD56+CD3-CD8+ NK cells
    • Addison et al., 2005 [1]
  • CD56+CD3-CD25+ activated NK cells
  • CD56+CD3-CD25- non-activated NK cells
  • CD56+CD3-CD69+ activated NK cells
  • CD56+CD3-CD69- non-activated NK cells
  • CD56+CD3-CD94+ NK cells
  • CD56+CD3-CD94- NK cells
  • CD56+CD3-CD57- non-exhausted NK cells
  • CD56+CD3-CD57+ exhausted NK cells
  • CD56+CD3-CD16- non-ADCC NKs
  • CD56+CD3-CD16+ regular NKs, capable of ADCC

Leukocyte subset with at least partial overlap with NK receptors:

• CD56+CD3+ NKT cells
  • CD161+CD3+ NKT cells is a more general definition as CD161 is not restricted to humans.
• CD56+CD3+TCRa/b-TCRg/d+ NKT cells
• CD56+CD3+TCRa/b+TCRg/d- NKT cells
• [iNKT]s
  • Valpha24 in humans, Valpha14 in mice
• CD56+CD14+ Monocytes

Further Reading

• CD56bright Natural Killer cells
• CD56dim Natural Killer cells
• NKT cells

References

References CD56-

Mavilio D, Lombardo G, Benjamin J, Kim D, Follman D, Marcenaro E, O'shea MA, Kinter A, Kovacs C, Moretta A, Fauci AS.
Characterization of CD56-/CD16+ natural killer (NK) cells: A highly dysfunctional NK subset expanded in HIV-infected viremic individuals.
Proc Natl Acad Sci U S A. 2005 Feb 7;. Epub PMID: 15699323 NKref0424

Nguyen S, Morel V, Le Garff-Tavernier M, Bolgert F, Leblond V, Debre P, Vieillard V.
Persistence of CD16(+)/CD56(-)/2B4(+) natural killer cells: A highly dysfunctional NK subset expanded in ocular myasthenia gravis.
J Neuroimmunol. 2006 Aug 10;. Epub, PMID:16904757

References CD56bright / CD56dim

Fan YY, Yang BY, Wu CY.
Phenotypically and functionally distinct subsets of natural killer cells in human PBMCs.
Cell Biol Int. 2007 Sep 7;., PMID:17920947

Evidence for NK Cell Subsets Based on Chemokine Receptor Expression
Berahovich, R. D., Lai, N. L., Wei, Z., Lanier, L. L., Schall, T. J.
J Immunol 2006 177: p. 7833-7840 NKref0529

Batoni G, Esin S, Favilli F, Pardini M, Bottai D, Maisetta G, Florio W, Campa M.
Human CD56dim and CD56bright Natural Killer Cell Subsets Respond Differentially to Direct Stimulation with Mycobacterium bovis Bacillus Calmette-Guerin.
Scand J Immunol. 2005 Dec;62(6):498-506. PMID: 16316416

Differential Mobilization of Functionally Distinct Natural Killer Subsets During Acute Psychologic Stress
Bosch, J. A., Berntson, G. G., Cacioppo, J. T., Marucha, P. T.
Psychosom Med 2005 67: p. 366-375

Differential expression of SHIP1 in CD56bright and CD56dim NK cells provides a molecular basis for distinct functional responses to monokine costimulation
Trotta, R., Parihar, R., Yu, J., Becknell, B., Allard, J. II, Wen, J.,Ding, W., Mao, H., Tridandapani, S., Carson, W. E., Caligiuri, M. A.
Blood 2005 105: p. 3011-3018

NK cell cytokine secretion regulated by SHIP1
Ritz, J.
Blood 2005 105: p. 3003-3003

The IL-12 Signature: NK Cell Terminal CD56+high Stage and Effector Functions
Loza, M. J., Perussia, B.
J Immunol 2004 172: p. 88-96

Vitale M, Della Chiesa M, Carlomagno S, Romagnani C, Thiel A, Moretta L, Moretta A.
The small subset of CD56brightCD16- natural killer cells is selectively responsible for both cell proliferation and interferon-gamma production upon interaction with dendritic cells.
Eur J Immunol. 2004 Jun;34(6):1715-22. PMID: 15162442 NKref0312 (CD56bright, NK/DC interaction)

Human natural killer cells: a unique innate immunoregulatory role for the CD56bright subset
Cooper, M. A., Fehniger, T. A., Turner, S. C., Chen, K. S., Ghaheri, B. A., Ghayur, T., Carson, W. E., Caligiuri, M. A.
Blood 2001 97: p. 3146-3151

Bratke K, Kuepper M, Bade B, Virchow JC Jr, Luttmann W.
Differential expression of human granzymes A, B, and K in natural killer cells and during CD8(+) T cell differentiation in peripheral blood.
Eur J Immunol. 2005 Aug 16;. Epub PMID: 16106370 NKref0479

References CD8+/- NK cells

Addison EG, North J, Bakhsh I, Marden C, Haq S, Al-Sarraj S, Malayeri R, Wickremasinghe RG, Davies JK, Lowdell MW.
Ligation of CD8alpha on human natural killer cells prevents activation-induced apoptosis and enhances cytolytic activity.
Immunology. 2005 Nov;116(3):354-61. PMID: 16236125 NKref0498

References murine B220+CD11c+NK1.1+ NK cells

Vosshenrich CA, Lesjean-Pottier S, Hasan M, Goff OR, Corcuff E, Mandelboim O, Di Santo JP.
CD11cloB220+ interferon-producing killer dendritic cells are activated natural killer cells.
J Exp Med. 2007 Oct 8;. Epub, PMID:17923507

Caminschi I, Ahmet F, Heger K, Brady J, Nutt SL, Vremec D, Pietersz S, Lahoud MH, Schofield L, Hansen DS, O'keeffe M, Smyth MJ, Bedoui S, Davey GM, Villadangos JA, Heath WR, Shortman K.
Putative IKDCs are functionally and developmentally similar to natural killer cells, but not to dendritic cells.
J Exp Med. 2007 Oct 8;. Epub, PMID:17923506

Blasius AL, Barchet W, Cella M, Colonna M.
Development and function of murine B220+CD11c+NK1.1+ cells identify them as a subset of NK cells.
J Exp Med. 2007 Oct 8;. Epub, PMID:17923504

References for additional NK cell subsets

Veinotte LL, Halim TY, Takei F.
Unique subset of natural killer cells develops from progenitors in lymph node.
Blood. 2008 Jan 28;. Epub, PMID:18227350