NK cell activation

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Contents

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Introduction

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While IL-2 is state of the art for NK cell activation, IL-15 seems to be superior: When comparing activation by IL-15 and IL-2, Ozdemir et al. (2005) demonstrated that the overall production of Perforin, Granzyme B and tumor necrosis factor-alpha was significantly higher with IL-15 alone or in combination with IL-2 compared to IL-2 alone.

Components of nutrition can also activate NK cells: Consumption of purple sweet potato leaves modulates various immune functions including increased proliferation responsiveness of PBMC, secretion of cytokines IL-2 and IL-4, and the lytic activity of NK cells (Chen, 2005 [1]).

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Literature

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2006

Gasser S, Raulet DH.
Activation and self-tolerance of natural killer cells.
Immunol Rev. 2006 Dec;214(1):130-42., PMID:17100881 NKref0527

Bryceson YT, March ME, Ljunggren HG, Long EO.
Activation, coactivation, and costimulation of resting human natural killer cells.
Immunol Rev. 2006 Dec;214(1):73-91., PMID:17100877 NKref0528

Distinct indirect pathways govern human NK-cell activation by TLR-7 and TLR-8 agonists
Gorski, K. S., Waller, E. L., Bjornton-Severson, J., Hanten, J. A., Riter, C. L., Kieper, W. C., Gorden, K. B., Miller, J. S., Vasilakos, J. P., Tomai, M. A., Alkan, S. S.
Int Immunol 2006 18: p. 1115-1126

Control of Metastasized Pancreatic Carcinomas in SCID/Beige Mice with Human IL-2/TKD-Activated NK Cells
Stangl, S., Wortmann, A., Guertler, U., Multhoff, G.
J Immunol 2006 176: p. 6270-6276

Goodier MR, Nawroly N, Beyan H, Hawa M, Leslie RD, Londei M.
Identical twins discordant for type 1 diabetes show a different pattern of in vitro CD56(+) cell activation.
Diabetes Metab Res Rev. 2006 Mar 30;. Epub, PMID:16572491

Hanabuchi S, Watanabe N, Wang YH, Wang YH, Ito T, Shaw J, Cao W, Qin FX, Liu YJ.
Human plasmacytoid pre-dendritic cells activate NK cells through glucocorticoid-induced tumor necrosis factor receptor-ligand (GITRL).
Blood. 2006 Jan 5; Epub PMID: 16397134 NKref0505 (NK/DC interaction)

Rajagopalan S, Bryceson YT, Kuppusamy SP, Geraghty DE, Meer AV, Joosten I, Long EO.
Activation of NK Cells by an Endocytosed Receptor for Soluble HLA-G.
PLoS Biol. 2005 Dec 27;4(1):e9 Epub PMID: 16366734 NKref0506 (KIR2DL4)

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2005

Osada T, Clay T, Hobeika A, Lyerly HK, Morse MA.
NK cell activation by dendritic cell vaccine: a mechanism of action for clinical activity.
Cancer Immunol Immunother. 2005 Nov 5;:1-10. Epub PMID: 16273350

Chen CM, Li SC, Lin YL, Hsu CY, Shieh MJ, Liu JF.
Consumption of purple sweet potato leaves modulates human immune response: T-lymphocyte functions, lytic activity of natural killer cell and antibody production.
World J Gastroenterol. 2005 Oct 7;11(37):5777-81. PMID: 16270384

Ozdemir O, Savasan S.
Combinational IL-2/IL-15 induction does not further enhance IL-15-induced lymphokine-activated killer cell cytotoxicity against human leukemia/lymphoma cells.
Clin Immunol. 2005 Jun;115(3):240-249. PMID: 15893691

Konstantinidis KV, Alici E, Aints A, Christensson B, Ljunggren HG, Dilber MS.
Targeting IL-2 to the endoplasmic reticulum confines autocrine growth stimulation to NK-92 cells.
Exp Hematol. 2005 Feb;33(2):159-64. PMID: 15676209

Tsujimoto H, Uchida T, Efron PA, Scumpia PO, Verma A, Matsumoto T, Tschoeke SK, Ungaro RF, Ono S, Seki S, Clare-Salzler MJ, Baker HV, Mochizuki H, Ramphal R, Moldawer LL.
Flagellin enhances NK cell proliferation and activation directly and through dendritic cell-NK cell interactions.
J Leukoc Biol. 2005 Jul 20;. Epub PMID: 16033815

Romagnani C, Della Chiesa M, Kohler S, Moewes B, Radbruch A, Moretta L, Moretta A, Thiel A.
Activation of human NK cells by plasmacytoid dendritic cells and its modulation by CD4(+) T helper cells and CD4(+) CD25(hi) T regulatory cells.
Eur J Immunol. 2005 Aug;35(8):2452-8. PMID: [Eur J Immunol. 2005 Aug;35(8):2452-8. 15997468] NKref0469

Bowles JA, Weiner GJ.
CD16 polymorphisms and NK activation induced by monoclonal antibody-coated target cells.
J Immunol Methods. 2005 Aug 15;. Epub PMID: 16109421 (ADCC)

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2004

Borg C, Jalil A, Laderach D, Maruyama K, Wakasugi H, Charrier S, Ryffel B, Cambi A, Figdor C, Vainchenker W, Galy A, Caignard A, Zitvogel L.
NK cell activation by dendritic cells (DCs) requires the formation of a synapse leading to IL-12 polarization in DCs.
Blood. 2004 Nov 15;104(10):3267-75. Epub 2004 Jul 08. PMID: 15242871 NKref0392

Ferlazzo G, Pack M, Thomas D, Paludan C, Schmid D, Strowig T, Bougras G, Muller WA, Moretta L, Munz C.
Distinct roles of IL-12 and IL-15 in human natural killer cell activation by dendritic cells from secondary lymphoid organs.
Proc Natl Acad Sci U S A. 2004 Nov 9;. Epub PMID: 15536127 NKref0392 (Journal Screen Immunology Nov 26th 2004)

André P, Castriconi R, Espéli M, Anfossi N, Juarez T, Hue S, Conway H, Romagné F, Dondero A, Nanni M, Caillat-Zucman S, Raulet DH, Bottino C, Vivier E, Moretta A, Paul P.
Comparative analysis of human NK cell activation induced by NKG2D and natural cytotoxicity receptors.
Eur J Immunol. 2004 Apr;34(4):961-71., PMID:15048706

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2002

Valteau-Couanet D, Leboulaire C, Maincent K, Tournier M, Hartmann O, Benard J, Beaujean F, Boccaccio C, Zitvogel L, Angevin E.
Dendritic cells for NK/LAK activation: rationale for multicellular immunotherapy in neuroblastoma patients.
Blood. 2002 Oct 1;100(7):2554-61., PMID:12239169 NKref0148

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1988

Shau H, Golub SH.
Modulation of natural killer-mediated lysis by red blood cells.
Cell Immunol. 1988 Oct 1;116(1):60-72. PMID: 2901915

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NK activating substances

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Web links

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References

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VH list for review

Mori S, Jewett A, Cavalcanti M, Murakami-Mori K, Nakamura S, Bonavida B.
Differential regulation of human NK cell-associated gene expression following activation by IL-2, IFN-alpha and PMA/ionomycin.
Int J Oncol. 1998 May;12(5):1165-70. PMID: 9538144

Vitale A, Guarini A, Latagliata R, Cignetti A, Foa R.
Cytotoxic effectors activated by low-dose IL-2 plus IL-12 lyse IL-2-resistant autologous acute myeloid leukaemia blasts.
Br J Haematol. 1998 Apr;101(1):150-7. PMID: 9576195

Mehrotra PT, Donnelly RP, Wong S, Kanegane H, Geremew A, Mostowski HS, Furuke K, Siegel JP, Bloom ET.
Production of IL-10 by human natural killer cells stimulated with IL-2 and/or IL-12.
J Immunol. 1998 Mar 15;160(6):2637-44. PMID: 9510161

Hellstrand K, Mellqvist UH, Wallhult E, Carneskog J, Kimby E, Celsing F, Brune M.
Histamine and interleukin-2 in acute myelogenous leukemia.
Leuk Lymphoma. 1997 Nov;27(5-6):429-38. PMID: 9477124

Pierson BA, Miller JS.
The role of autologous natural killer cells in chronic myelogenous leukemia.
Leuk Lymphoma. 1997 Nov;27(5-6):387-99. Review. PMID: 9477121

Gratama JW, Bruin RJ, Lamers CH, Oosterom R, Braakman E, Stoter G, Bolhuis RL.
Activation of the immune system of cancer patients by continuous i.v. recombinant IL-2 (rIL-2) therapy is dependent on dose and schedule of rIL-2.
Clin Exp Immunol. 1993 May;92(2):185-93. PMID: 8485906

Hauer J, Anderer FA.
Mechanism of stimulation of human natural killer cytotoxicity by arabinogalactan from Larix occidentalis.
Cancer Immunol Immunother. 1993;36(4):237-44. PMID: 8439987

Vuist WM, Visseren MJ, Otsen M, Bos K, Vyth-Dreese FA, Figdor CG, Melief CJ, Hekman A.
Enhancement of the antibody-dependent cellular cytotoxicity of human peripheral blood lymphocytes with interleukin-2 and interferon alpha.
Cancer Immunol Immunother. 1993;36(3):163-70. PMID: 8439976

Lebow LT, Jewett A, Bonavida B.
Killer cell recruitment and renewal capacity of purified cytolytic and noncytolytic human peripheral blood natural killer cell subsets.
J Immunol. 1993 Jan 1;150(1):320-9. PMID: 8417130

Pavel Krist
PhD Thesis: Preparation of novel glycoconjugates for NK-cell activation
(Synopsis)

Chien RN, Liaw YF.
Thymalfasin for the treatment of chronic hepatitis B.
Expert Rev Anti Infect Ther. 2004 Feb;2(1):9-16. PMID: 15482167

Mirandola P, Ponti C, Gobbi G, Sponzilli I, Melloni E, Vitale M.
The response of human natural killer cells to interleukin-2.
J Endocrinol Invest. 2004;27 Suppl(6):146-50. PMID: 15481816

Konstantinidis KV, Alici E, Aints A, Christensson B, Ljunggren HG, Dilber MS.
Targeting IL-2 to the endoplasmic reticulum confines autocrine growth stimulation to NK-92 cells.
Exp Hematol. 2005 Feb;33(2):159-64. PMID: 15676209

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