NKG2D

From NKcells.info

Contents

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Introduction

NKG2D is one of the major triggering receptors of NK cells. Garrity et al. (2005) demonstrated that one NKG2D homodimer assembles with four DAP10 chains which may result in triggering also at low ligand density on target cells as binding of a single ligand can result in phosphorylation of four DAP10 chains.

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Synonyms

KLRK1; killer cell lectin-like receptor subfamily K, member 1; klr; CD314

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Ligands

Known NKG2D-ligands in humans are MICA, MICB, ULBP1, ULBP2, ULBP3, and more recently MICC and ULBP4.

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Antibodies

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Web Links

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References

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2008

Yi Qiao, Bei Liu and Zihai Li
Activation of NK cells by extracellular heat shock protein 70 through induction of [NKG2D] ligands on dendritic cells
Cancer Immun [serial online 2008; 8:12.]

López-Larrea C, Suárez-Alvarez B, López-Soto A, López-Vázquez A, Gonzalez S.
The NKG2D receptor: sensing stressed cells.
Trends Mol Med. 2008 Mar 17;. Epub, PMID:18353724

Fang M, Lanier LL, Sigal LJ.
A Role for NKG2D in NK Cell-Mediated Resistance to Poxvirus Disease.
PLoS Pathog. 2008 Feb 8;4(2):e30. Epub, PMID:18266471

Mair Thomas, Jessica M. Boname, Sarah Field, Sergey Nejentsev, Mariolina Salio, Vincenzo Cerundolo, Mark Wills, and Paul J. Lehner
Down-regulation of NKG2D and NKp80 ligands by Kaposi's sarcoma-associated herpesvirus K5 protects against NK cell cytotoxicity
Proc. Natl. Acad. Sci. USA, 10.1073/pnas.0707883105 NKref0552

Takada, A., Kasahara, M., Takada, A., Kasahara, M.
Two Novel NKG2D Ligands of the Mouse H60 Family with Differential Expression Patterns and Binding Affinities to NKG2D
The Journal of Immunology, 2008, 180: 1678-1685., NKref0550

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2007

Wrobel P, Shojaei H, Schittek B, Gieseler F, Wollenberg B, Kalthoff H, Kabelitz D, Wesch D.
Lysis of a broad range of epithelial tumour cells by human gamma delta T cells: involvement of NKG2D ligands and T-cell receptor- versus NKG2D-dependent recognition.
Scand J Immunol. 2007 Aug-Sep;66(2-3):320-8., PMID:17635809, [[6]]

Sílvia Vilarinho, Kouetsu Ogasawara, Stephen Nishimura, Lewis L. Lanier, and Jody L. Baron
Blockade of NKG2D on NKT cells prevents hepatitis and the acute immune response to hepatitis B virus
Proc. Natl. Acad. Sci. USA, 10.1073/pnas.0708968104

Ebihara, T., Masuda, H., Akazawa, T., Shingai, M., Kikuta, H., Ariga, T., Matsumoto, M., Seya, T.
Induction of NKG2D ligands on human dendritic cells by TLR ligand stimulation and RNA virus infection
Int Immunol 2007 0: p. dxm073v1-dxm073, NKref0547

Jim Kim, Catherine K. Chang, Tracy Hayden, Feng-Chun Liu, Jonathan Benjamin, Jessica A. Hamerman, Lewis L. Lanier and Sang-Mo Kang
The Activating Immunoreceptor NKG2D and Its Ligands Are Involved in Allograft Transplant Rejection
The Journal of Immunology, 2007, 179: 6416-6420.

Zimmer J, Michel T, Andres E, Hentges F.
Up-regulation of NKG2D ligands by AML cells to increase sensitivity to NK cells: The tumour might strike back Comment on "Differentiation-promoting drugs up-regulate NKG2D ligand expression and enhance the susceptibility of acute myeloid leukemia cells to natural killer cell-mediated lysis" by Rohner et al. [Leuk Res 2007;31:1393-402].
Leuk Res. 2007 Oct 5;. Epub, PMID:17920678

Poggi A, Prevosto C, Zancolli M, Canevali P, Musso A, Zocchi MR.
NKG2D and Natural Cytotoxicity Receptors Are Involved in Natural Killer Cell Interaction with Self-Antigen Presenting Cells and Stromal Cells.
Ann N Y Acad Sci. 2007 Sep;1109:47-57., PMID:17785290

Eagle RA, Trowsdale J.
Promiscuity and the single receptor: NKG2D.
Nat Rev Immunol. 2007 Aug 3;. PMID:17673918

Maccalli C, Nonaka D, Piris A, Pende D, Rivoltini L, Castelli C, Parmiani G.
NKG2D-mediated antitumor activity by tumor-infiltrating lymphocytes and antigen-specific T-cell clones isolated from melanoma patients.
Clin Cancer Res. 2007 Dec 15;13(24):7459-68., PMID:18094430

Endt J, McCann FE, Almeida CR, Urlaub D, Leung R, Pende D, Davis DM, Watzl C.
Inhibitory receptor signals suppress ligation-induced recruitment of NKG2D to GM1-rich membrane domains at the human NK cell immune synapse.
J Immunol. 2007 May 1;178(9):5606-11., PMID:17442943

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2006

Cerboni C, Neri F, Casartelli N, Zingoni A, Cosman D, Rossi P, Santoni A, Doria M.
Human immunodeficiency virus 1 Nef protein downmodulates the ligands of the activating receptor NKG2D and inhibits natural killer cell-mediated cytotoxicity.
J Gen Virol. 2007 Jan;88(Pt 1):242-50. PMID:17170457

Poggi A, Zocchi MR.
Antigen presenting cells and stromal cells trigger human natural killer lymphocytes to autoreactivity: Evidence for the involvement of natural cytotoxicity receptors (NCR) and NKG2D.
Clin Dev Immunol. 2006 Jun-Dec;13(2):325-36., PMID:17162374

Coudert JD, Held W.
The role of the NKG2D receptor for tumor immunity.
Semin Cancer Biol. 2006 Jul 8;. Epub, PMID:16914326

Gasser S, Raulet D.
The DNA damage response, immunity and cancer.
Semin Cancer Biol. 2006 Jul 7;. Epub, PMID:16914325

Della Chiesa M, Carlomagno S, Frumento G, Balsamo M, Cantoni C, Conte R, Moretta L, Moretta A, Vitale M.
The tryptophan catabolite L-kynurenine inhibits the surface expression of NKp46 and NKG2D activating receptors and regulates NK cell function.
Blood. 2006 Aug 10;. Epub, PMID:16902152

ULBPs, human ligands of the NKG2D receptor, stimulate tumor immunity with enhancement by IL-15
 Claire L. Sutherland, Brian Rabinovich, N. Jan Chalupny, Pierre Brawand, Robert Miller, and David Cosman
Blood 2006;108 1313-1319

Roda-Navarro P, Vales-Gomez M, Chisholm SE, Reyburn HT.
Transfer of NKG2D and MICB at the cytotoxic NK cell immune synapse correlates with a reduction in NK cell cytotoxic function.
Proc Natl Acad Sci U S A. 2006 Jul 18;. Epub, PMID:16849432

Jinushi M, Hodi FS, Dranoff G.
Therapy-induced antibodies to MHC class I chain-related protein A antagonize immune suppression and stimulate antitumor cytotoxicity.
Proc Natl Acad Sci U S A. 2006 Jun 5;. Epub, PMID:16754847, NKref0513

Chalupny NJ, Rein-Weston A, Dosch S, Cosman D.
Down-regulation of the NKG2D ligand MICA by the human cytomegalovirus glycoprotein UL142.
Biochem Biophys Res Commun. 2006 May 24;. Epub, PMID:16750166

Zhang T, Barber A, Sentman CL.
Generation of Antitumor Responses by Genetic Modification of Primary Human T Cells with a Chimeric NKG2D Receptor.
Cancer Res. 2006 Jun 1;66(11):5927-33., PMID:16740733

Hayakawa Y, Smyth MJ.
NKG2D and cytotoxic effector function in tumor immune surveillance.
Semin Immunol. 2006 May 1;. Epub, PMID:16675266

Upshaw JL, Arneson LN, Schoon RA, Dick CJ, Billadeau DD, Leibson PJ.
NKG2D-mediated signaling requires a DAP10-bound Grb2-Vav1 intermediate and phosphatidylinositol-3-kinase in human natural killer cells.
Nat Immunol. 2006 Apr 2;. Epub, PMID:16582911

IFN-Dependent Down-Regulation of the NKG2D Ligand H60 on Tumors
Bui, J. D., Carayannopoulos, L. N., Lanier, L. L., Yokoyama, W. M., Schreiber, R. D.
J Immunol 2006 176: p. 905-913

The Decreased Susceptibility of Bcr/Abl Targets to NK Cell-Mediated Lysis in Response to Imatinib Mesylate Involves Modulation of NKG2D Ligands, GM1 Expression, and Synapse Formation
Cebo, C., Da Rocha, S., Wittnebel, S., Turhan, A. G., Abdelali, J., Caillat-Zucman, S., Bourhis, J. H., Chouaib, S., Caignard, A.
J Immunol 2006 176: p. 864-872

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2005

Poggi A, Prevosto C, Massaro AM, Negrini S, Urbani S, Pierri I, Saccardi R, Gobbi M, Zocchi MR.
Interaction between human NK cells and bone marrow stromal cells induces NK cell triggering: role of NKp30 and NKG2D receptors.
J Immunol. 2005 Nov 15;175(10):6352-60., PMID:16272287 NKref521

Wiemann K, Mittrucker HW, Feger U, Welte SA, Yokoyama WM, Spies T, Rammensee HG, Steinle A.
Systemic NKG2D down-regulation impairs NK and CD8 T cell responses in vivo.
J Immunol. 2005 Jul 15;175(2):720-9., PMID:16002667

Gonzalez S, Groh V, Spies T.
Immunobiology of human NKG2D and its ligands.
Curr Top Microbiol Immunol. 2006;298:121-38. PMID: 16329186

Skov S, Pedersen MT, Andresen L, Thor Straten P, Woetmann A, Odum N.
Cancer cells become susceptible to natural killer cell killing after exposure to histone deacetylase inhibitors due to glycogen synthase kinase-3-dependent expression of MHC class I-related chain A and B.
Cancer Res. 2005 Dec 1;65(23):11136-45. PMID: 16322264 (MICA, NKG2DL)

Routes JM, Ryan S, Morris K, Takaki R, Cerwenka A, Lanier LL.
Adenovirus serotype 5 E1A sensitizes tumor cells to NKG2D-dependent NK cell lysis and tumor rejection.
J Exp Med. 2005 Nov 28;. Epub PMID: 16314433

Gasser S, Orsulic S, Brown EJ, Raulet DH.
The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor.
Nature. 2005 Aug 25;436(7054):1186-90. Epub 2005 Jul 3. PMID: 15995699 NKref0496

Dandekar AA, O'Malley K, Perlman S.
Important roles for gamma interferon and NKG2D in gammadelta T-cell-induced demyelination in T-cell receptor beta-deficient mice infected with a coronavirus.
J Virol. 2005 Aug;79(15):9388-96. PMID: 16014902

A novel bispecific protein (ULBP2-BB4) targeting the NKG2D receptor on natural killer (NK) cells and CD138 activates NK cells and has potent antitumor activity against human multiple myeloma in vitro and in vivo
Elke Pogge von Strandmann, Hinrich P. Hansen, Katrin S. Reiners, Roland Schnell, Peter Borchmann, Sabine Merkert, Venkateswara R. Simhadri, Andreas Draube, Marcel Reiser, Ingvill Purr, Michael Hallek, and Andreas Engert
Blood published 6 October 2005, 10.1182/blood-2005-05-2177 NKref0482

Smyth MJ, Swann J, Cretney E, Zerafa N, Yokoyama WM, Hayakawa Y.
NKG2D function protects the host from tumor initiation.
J Exp Med. 2005 Aug 29;. Epub PMID: 16129707

Sconocchia G, Lau M, Provenzano M, Rezvani K, Wongsena W, Fujiwara H, Hensel N, Melenhorst J, Li J, Ferrone S, Barrett J.
The antileukemia effect of HLA-matched NK and NK-T cells in chronic myelogenous leukemia involves NKG2D-target cell interaction.
Blood. 2005 Jul 26;. Epub PMID: 16046526 NKref0478 (MICA shedding)

Gasser S, Orsulic S, Brown EJ, Raulet DH.
The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor.
Nature. 2005 Aug 25;436(7054):1186-90. Epub 2005 Jul 3. PMID: 15995699

Garrity D, Call ME, Feng J, Wucherpfennig KW.
The activating NKG2D receptor assembles in the membrane with two signaling dimers into a hexameric structure.
Proc Natl Acad Sci U S A. 2005 May 13;. Epub PMID: 15894612 NKref0473

Altered NKG2D function in NK cells induced by chronic exposure to NKG2D-ligand expressing tumor cells
Jerome D Coudert, Jacques Zimmer, Elena Tomasello, Marek Cebecauer, Marco Colonna, Eric Vivier, and Werner Held
Blood published 10 May 2005, 10.1182/blood-2005-03-0918 NKref0436

Ogasawara K, Benjamin J, Takaki R, Phillips JH, Lanier LL.
Function of NKG2D in natural killer cell-mediated rejection of mouse bone marrow grafts.
Nat Immunol. 2005 Aug 7;. Epub PMID: 16086018 NKref0477

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2004

Meresse B, Chen Z, Ciszewski C, Tretiakova M, Bhagat G, Krausz TN, Raulet DH, Lanier LL, Groh V, Spies T, Ebert EC, Green PH, Jabri B
Coordinated Induction by IL15 of a TCR-Independent NKG2D Signaling Pathway Converts CTL into Lymphokine-Activated Killer Cells in Celiac Disease.
Immunity. 2004 Sep;21(3):357-66. PMID: 15357947

Carbone E, Neri P, Mesuraca M, Fulciniti M, Otsuki T, Pende D, Groh V, Spies T, Pollio G, Cosman D, Catalano L, Tassone P, Rotoli B, Venuta S
HLA class I, NKG2D and natural cytotoxicity receptors regulate multiple myeloma cell recognition by natural killer cells.
Blood. 2004 Aug 24;. Epub PMID: 15328155 NKref0456

Lee JC, Lee KM, Kim DW, Heo DS.
Elevated TGF-beta1 secretion and down-modulation of NKG2D underlies impaired NK cytotoxicity in cancer patients.
J Immunol. 2004 Jun 15;172(12):7335-40. PMID: 15187109 NKref0363

Andre P, Castriconi R, Espeli M, Anfossi N, Juarez T, Hue S, Conway H, Romagne F, Dondero A, Nanni M, Caillat-Zucman S, Raulet DH, Bottino C, Vivier E, Moretta A, Paul P.
Comparative analysis of human NK cell activation induced by NKG2D and natural cytotoxicity receptors.
Eur J Immunol. 2004 Apr;34(4):961-71. PMID: 15048706 NKref0291

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2003

Verneris MR, Karami M, Baker J, Jayaswal A, Negrin RS.
Role of NKG2D signaling in the cytotoxicity of activated and expanded CD8+ T cells.
Blood. 2004 Apr 15;103(8):3065-72. Epub 2003 Nov 20. PMID: 15070686 NKref0290

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2002

Jamieson AM, Diefenbach A, McMahon CW, Xiong N, Carlyle JR, Raulet DH.
The role of the NKG2D immunoreceptor in immune cell activation and natural killing.
Immunity. 2002 Jul;17(1):19-29 PMID: 12150888

Diefenbach A, Tomasello E, Lucas M, Jamieson AM, Hsia JK, Vivier E, Raulet DH.
Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D.
Nat Immunol. 2002 Dec;3(12):1142-9. PMID: 12426565

Hayakawa Y, Kelly JM, Westwood JA, Darcy PK, Diefenbach A, Raulet D, Smyth MJ.
Cutting edge: tumor rejection mediated by NKG2D receptor-ligand interaction is dependent upon perforin.
J Immunol. 2002 Nov 15;169(10):5377-81. PMID: 12421908

Groh V, Wu J, Yee C, Spies T.
Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation.
Nature. 2002 Oct 17;419(6908):734-8. PMID: 12384702 NKref0474

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