KIR2DS1
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Contents |
Introduction
Ligands
Clinical correlations point to interaction of activating KIRs with HLA class I similar to those of inhibitory receptors. Nevertheless controlled studies of ligand-binding specifities did not provide reliable results (Abi-Rached, 2005). Similarity of the extracellular (ligand binding) domains of KIR2DS1 and KIR2DL1 would propose identical HLA-C ligands, but affinity of HLA-C to KIR2DS1 is very low, probably caused by single-amino acid substitutions(Abi-Rached, 2005; Vales-Gomez, 1998).
KIR2DS1 and diseases
Certain combinations of HLA-C with KIR2DS1 and KIR2DS2 appear to correlate with autoimmune diseases such as type I diabetes, rheumatoid or psoriatic arthritis (Yen, 2001; Martin, 2002; van der Slik, 2003; Luszczek, 2004).
References
2006
Ploski R, Luszczek W, Kusnierczyk P, Nockowski P, Cislo M, Krajewski P, Malejczyk J.
A Role for KIR Gene Variants Other Than KIR2DS1 in Conferring Susceptibility to Psoriasis.
Hum Immunol. 2006 Jul;67(7):521-6., PMID:16829306
2005 and earlier
Martin MP, Nelson G, Lee JH, Pellett F, Gao X, Wade J, Wilson MJ, Trowsdale J, Gladman D, Carrington M.
Cutting edge: susceptibility to psoriatic arthritis: influence of activating killer Ig-like receptor genes in the absence of specific HLA-C alleles.
J Immunol. 2002 Sep 15;169(6):2818-22. PMID: 12218090
Yen JH, Moore BE, Nakajima T, Scholl D, Schaid DJ, Weyand CM, Goronzy JJ.
Major histocompatibility complex class I-recognizing receptors are disease risk genes in rheumatoid arthritis.
J Exp Med. 2001 May 21;193(10):1159-67. PMID: 11369787
van der Slik AR, Koeleman BP, Verduijn W, Bruining GJ, Roep BO, Giphart MJ.
KIR in type 1 diabetes: disparate distribution of activating and inhibitory natural killer cell receptors in patients versus HLA-matched control subjects.
Diabetes. 2003 Oct;52(10):2639-42. PMID: 14514651
Abi-Rached L, Parham P.
Natural selection drives recurrent formation of activating killer cell immunoglobulin-like receptor and Ly49 from inhibitory homologues.
J Exp Med. 2005 Apr 18;201(8):1319-32. PMID: 15837816 NKref0434
Vales-Gomez M, Reyburn HT, Erskine RA, Strominger J.
Differential binding to HLA-C of p50-activating and p58-inhibitory natural killer cell receptors.
Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14326-31. PMID: 9826699
LUszczek W, Manczak M, Cislo M, Nockowski P, Wisniewski A, Jasek M, Kusnierczyk P
Gene for the activating natural killer cell receptor, KIR2DS1, is associated with susceptibility to psoriasis vulgaris.
Hum Immunol. 2004 Jul;65(7):758-66. PMID: 15310528
