KIR2DL2
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Scientific snippets
Chrul et al. (2006, PMID:17047292) demonstrated that stimulation of NK cells by a mixture of IL-12 and IL-18 caused a significant increase in KIR2DL1+ and KIR2DL2+ NK cells but not in KIR3DL2+ cells, while stimulation with IL-2 increased the frequency of all three subsets.
KIR2DL2 and diseases
Momot T et al. (2004) demonstrated tha the genetic combination of KIR2DS2+ and KIR2DL2- is associated with scleroderma: 12/102 patients with scleroderma, compared with only 2/100 blood donors, had KIR phenotypes characterized by the presence of the activating KIR2DS2 and the absence of the corresponding inactivating KIR2DL2. [1]
References
2006
Chrul S, Polakowska E, Szadkowska A, Bodalski J.
Influence of Interleukin IL-2 and IL-12 + IL-18 on Surface Expression of Immunoglobulin-Like Receptors KIR2DL1, KIR2DL2, and KIR3DL2 in Natural Killer Cells.
Mediators Inflamm. 2006;2006(4):46957., PMID:17047292
2004
Nikitina-Zake L, Rajalingham R, Rumba I, Sanjeevi CB.
Killer Cell Immunoglobulin-like Receptor Genes in Latvian Patients with Type 1 Diabetes Mellitus and Healthy Controls.
Ann N Y Acad Sci. 2004 Dec;1037:161-9. PMID: 15699512 (KIR2DL2, KIR2DS2)
Momot T, Koch S, Hunzelmann N, Krieg T, Ulbricht K, Schmidt RE, Witte T
Association of killer cell immunoglobulin-like receptors with scleroderma.
Arthritis Rheum. 2004 May;50(5):1561-5. PMID: 15146426
