IL-12
From NKcells.info
Contents |
Introduction
...
IL-5 production of proliferating NK cells is reduced in the presence of IL-12 (Warren et al., 1995). CD8alpha+ DCs produce IL-12 in response to glycolipid presentation, which stimulates secondary IFN-gamma production by NK cells in different organs (Schmieg et al., 2005)
Chrul et al. (2006, PMID:17047292) demonstrated that stimulation of NK cells by a mixture of IL-12 and IL-18 caused a significant increase in KIR2DL1+ and KIR2DL2+ NK cells but not in KIR3DL2+ cells, while stimulation with IL-2 increased the frequency of all three subsets.
Ligands
CD212 (IL-12 receptor)
References
2006
Bachmayer N, Rafik Hamad R, Liszka L, Bremme K, Sverremark-Ekstrom E.
Aberrant Uterine Natural Killer (NK)-Cell Expression and Altered Placental and Serum Levels of the NK-Cell Promoting Cytokine Interleukin-12 in Pre-Eclampsia.
Am J Reprod Immunol. 2006 Nov;56(5-6):292-301., PMID:17076673
Plewako H, Wosinska K, Arvidsson M, Bjorkander J, Hakansson L, Rak S.
Production of interleukin-12 by monocytes and interferon-gamma by natural killer cells in allergic patients during rush immunotherapy.
Ann Allergy Asthma Immunol. 2006 Oct;97(4):464-8., PMID:17069100
Chrul S, Polakowska E, Szadkowska A, Bodalski J.
Influence of Interleukin IL-2 and IL-12 + IL-18 on Surface Expression of Immunoglobulin-Like Receptors KIR2DL1, KIR2DL2, and KIR3DL2 in Natural Killer Cells.
Mediators Inflamm. 2006;2006(4):46957., PMID:17047292
Takeda K, Suzuki T, Shimada SI, Shida K, Nanno M, Okumura K.
Interleukin-12 is involved in the enhancement of human natural killer cell activity by Lactobacillus casei Shirota.
Clin Exp Immunol. 2006 Oct;146(1):109-15., PMID:16968405
2005
Schmieg J, Yang G, Franck RW, Van Rooijen N, Tsuji M.
Glycolipid presentation to natural killer T cells differs in an organ-dependent fashion.
Proc Natl Acad Sci U S A. 2005 Jan 11;. Epub PMID: 15644449 NKref0431
Yue SC, Shaulov A, Wang R, Balk SP, Exley MA.
CD1d ligation on human monocytes directly signals rapid NF-{kappa}B activation and production of bioactive IL-12.
Proc Natl Acad Sci U S A. 2005 Aug 9;. Epub PMID: 16091469
2004
Ferlazzo G, Pack M, Thomas D, Paludan C, Schmid D, Strowig T, Bougras G, Muller WA, Moretta L, Munz C.
Distinct roles of IL-12 and IL-15 in human natural killer cell activation by dendritic cells from secondary lymphoid organs.
Proc Natl Acad Sci U S A. 2004 Nov 9;. Epub PMID: 15536127 NKref0392
The IL-12 Signature: NK Cell Terminal CD56+high Stage and Effector Functions
Loza, M. J., Perussia, B.
J Immunol 2004 172: p. 88-96
Borg C, Jalil A, Laderach D, Maruyama K, Wakasugi H, Charrier S, Ryffel B, Cambi A, Figdor C, Vainchenker W, Galy A, Caignard A, Zitvogel L.
NK cell activation by dendritic cells (DCs) requires the formation of a synapse leading to IL-12 polarization in DCs.
Blood. 2004 Nov 15;104(10):3267-75. Epub 2004 Jul 08. PMID: 15242871 NKref0392
Rakhmilevich AL, Hooper AT, Hicklin DJ, Sondel PM
Treatment of experimental breast cancer using interleukin-12 gene therapy combined with anti-vascular endothelial growth factor receptor-2 antibody.
Mol Cancer Ther. 2004 Aug;3(8):969-76. PMID: 15299079
2002
Vitale M, Bassini A, Secchiero P, Mirandola P, Ponti C, Zamai L, Mariani AR, Falconi M, Azzali G.
NK-active cytokines IL-2, IL-12, and IL-15 selectively modulate specific protein kinase C (PKC) isoforms in primary human NK cells.
Anat Rec. 2002 Feb 1;266(2):87-92. PMID: 11788941
2001 and earlier
Warren HS, Kinnear BF, Phillips JH, Lanier LL.
Production of IL-5 by human NK cells and regulation of IL-5 secretion by IL-4, IL-10, and IL-12.
J Immunol. 1995 May 15;154(10):5144-52. PMID: 7730620
