HIV
From NKcells.info
Summary
Ye et al. (2006, PMID:16987076) report that the level of CD226 expression on humans T cells, T Helper cells, cytotoxic T cells and NK cells of HIV patients as well as the level of soluble CD226 in the plasma of patients was significantly higher than that of normal controls. They assume that CD226 may be involved in the immune response to HIV infection.
References
Ye X, Zhang Z, Jiang Y, Han X, Wang Y, Zhang M, Liu J, Geng W, Dai D, Shi W, Shang H.
Expression of Human CD226 on T Cells and Natural Killer Cells and of Soluble CD226 in Plasma of HIV-1-Infected Chinese Patients.
Viral Immunol. 2006 Fall;19(3):576-81., PMID:16987076
Qi Y, Martin MP, Gao X, Jacobson L, Goedert JJ, Buchbinder S, Kirk GD, O'brien SJ, Trowsdale J, Carrington M.
KIR/HLA Pleiotropism: Protection against Both HIV and Opportunistic Infections.
PLoS Pathog. 2006 Aug 18;2(8). Epub, PMID:16933987
Beck JM.
The Immunocompromised Host: HIV Infection.
Proc Am Thorac Soc. 2005;2(5):423-7. PMID: 16322594 (includes NK cell function, free fulltext, PDF) NKref0499
Nuvor SV, van der Sande M, Rowland-Jones S, Whittle H, Jaye A.
Natural Killer Cell Function Is Well Preserved in Asymptomatic Human Immunodeficiency Virus Type 2 (HIV-2) Infection but Similar to That of HIV-1 Infection When CD4 T-Cell Counts Fall.
J Virol. 2006 Mar;80(5):2529-38., PMID:16474159
Fauci AS, Mavilio D, Kottilil S.
NK cells in HIV infection: paradigm for protection or targets for ambush.
Nat Rev Immunol. 2005 Nov;5(11):835-43. Review. PMID: 16239902 NKref0503
Gupta N, Arthos J, Khazanie P, Steenbeke TD, Censoplano NM, Chung EA, Cruz CC, Chaikin MA, Daucher M, Kottilil S, Mavilio D, Schuck P, Sun PD, Rabin RL, Radaev S, Van Ryk D, Cicala C, Fauci AS.
Targeted lysis of HIV-infected cells by natural killer cells armed and triggered by a recombinant immunoglobulin fusion protein: implications for immunotherapy.
Virology. 2005 Feb 20;332(2):491-7. PMID: 15680414
Ward J, Bonaparte M, Sacks J, Guterman J, Fogli M, Mavilio D, Barker E.
HIV modulates the expression of ligands important in triggering natural killer cell cytotoxic responses on infected primary T-cell blasts.
Blood. 2007 Aug 15;110(4):1207-14. Epub 2007 May 18., PMID:17513617
Mavilio D, Lombardo G, Benjamin J, Kim D, Follman D, Marcenaro E, O'Shea MA, Kinter A, Kovacs C, Moretta A, Fauci AS.
Characterization of CD56-/CD16+ natural killer (NK) cells: a highly dysfunctional NK subset expanded in HIV-infected viremic individuals.
Proc Natl Acad Sci U S A. 2005 Feb 22;102(8):2886-91. Epub 2005 Feb 7., PMID:15699323 (Free in PMC)
Mavilio D, Benjamin J, Daucher M, Lombardo G, Kottilil S, Planta MA, Marcenaro E, Bottino C, Moretta L, Moretta A, Fauci AS.
Natural killer cells in HIV-1 infection: dichotomous effects of viremia on inhibitory and activating receptors and their functional correlates.
Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15011-6. Epub 2003 Nov 25. Erratum in: Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):6326., PMID:14645713 (Free in PMC)
