Granzyme H
From NKcells.info
Contents |
Introduction
Granzyme H (GzmH, GrH) is a human serine protease, closely related and predicted to evolve from Granzyme B. Cells are efficiently killed by Granzyme H when delivered into the cytosol. It is contrarily discussed whether cell death mediated by Granzyme H does involve the activation of caspases. Granzyme H is constitutively expressed in naive human natural killer cells at high levels.
Synonyms
- cathepsin G-like 2
- protein h-CCPX
- CGL-2
- CCP-X
- CTLA1
- CSP-C
Antibodies
- 4G5, Sedelies 2004
References
MacIvor DM, Pham CT, Ley TJ.
The 5' flanking region of the human granzyme H gene directs expression to T/natural killer cell progenitors and lymphokine-activated killer cells in transgenic mice.
Blood. 1999 Feb 1;93(3):963-73., PMID:9920846
Sedelies KA, Sayers TJ, Edwards KM, Chen W, Pellicci DG, Godfrey DI, Trapani JA.
Discordant regulation of granzyme H and granzyme B expression in human lymphocytes.
J Biol Chem. 2004 Jun 18;279(25):26581-7. Epub 2004 Apr 6., PMID:15069086
Fellows E, Gil-Parrado S, Jenne DE, Kurschus FC.
Natural killer cell-derived human granzyme H induces an alternative, caspase-independent cell-death program.
Blood. 2007 Jul 15;110(2):544-52. Epub 2007 Apr 4., PMID:17409270
Hou Q, Zhao T, Zhang H, Lu H, Zhang Q, Sun L, Fan Z.
Granzyme H induces apoptosis of target tumor cells characterized by DNA fragmentation and Bid-dependent mitochondrial damage.
Mol Immunol. 2007 Aug 31;. Epub, PMID:17765974
