Gamma/delta T cell
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Contents |
Introduction
Gamma/delta T cells are part of the innate immune system. They exhibit a MHC-unrestricted lytic activity against different tumor cells in vitro (Wilhelm et al., 2003; Kunzmann et al., 2000; Sicard et al., 2001; Kato et al., 2001) similar to NK cells. Gamma/delta T cells can be activated by synthetic aminobisphosphonates (e.g. Novartis' Pamidronate and can be expanded both in vitro and in vivo by a combination of Pamidronate and low dose IL-2 (Wilhelm et al., 2003)
gamma/delta T cells and diseases
In vivo activation and expansion of gamma/delta T cells has been used by Wilhelm et al. (Blood 2003) to treat NHL or MM patients previously tested for in vitro proliferation of gamma/delta T cells upon addition of bisphosphonate and IL-2. In vivo proliferation was observed in 5 of 9 patients (pre-screened for in vitro proliferation of gamma/delta T cells) and clinical responses were observed in 3 of these 5 patients.
They demonstrated that fewer patients with hematologic malignancies than a control group of healthty volunteers (49% vs. 88%) showed pamidronate/IL-2 induced gamma/delta T cell proliferation in vitro, which might be due to prior chemotherapy in these patients.
Kunzmann and Wilhelm (2005, [1]) review evidence of pre-clinical and early clinical studies regarding the contribution of gamma/delta T cells in the defense against lymphoid malignancies. They describe that Vd2Vg9 T cells exert cytotoxic activity against lymphoid malignancies, pointing to potential use of stem cell grafts that contain gamma/delta T cells or gamma/delta T cell donor lymphocyte infusions.
Also see
Web Links
- Poster presentation: Bisphosphonic acid acts as Gamma/Delta T cell activating antigen and has direct cytotoxic activity against pancreatic carcinoma cells
- Mechanismen der Antigen-Erkennung durch gamma/delta T-Lymphozyten (german)
- Yueh-hsiu Chien, Profile
- Gamma-delta T cells promote wound repair
- pamidronate drug information
- MedlinePlus Drug Information: Pamidronate
- Stimulation or Inhibition of Gamma Delta T-Cells to Promote or Inhibit Bone Growth
References
2007
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Morita CT, Jin C, Sarikonda G, Wang H.
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2006
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2005
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Anti-lymphoma effect of gamma/delta T cells.
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2004
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Role of gammadelta T lymphocytes in tumor defense.
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2003
Wilhelm M, Kunzmann V, Eckstein S, Reimer P, Weissinger F, Ruediger T, Tony HP.
Gammadelta T cells for immune therapy of patients with lymphoid malignancies.
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2001
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Human gammadelta(+) T lymphocytes have in vitro graft vs leukemia activity in the absence of an allogeneic response.
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Synthetic phosphoantigens enhance human Vgamma9Vdelta2 T lymphocytes killing of non-Hodgkin's B lymphoma.
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2000
Kunzmann V, Bauer E, Feurle J, Weissinger F, Tony HP, Wilhelm M.
Stimulation of gammadelta T cells by aminobisphosphonates and induction of antiplasma cell activity in multiple myeloma.
Blood. 2000 Jul 15;96(2):384-92. PMID: 10887096
Schilbach KE, Geiselhart A, Wessels JT, Niethammer D, Handgretinger R.
Human gammadelta T lymphocytes exert natural and IL-2-induced cytotoxicity to neuroblastoma cells.
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1999
Drobyski WR, Majewski D, Hanson G.
Graft-facilitating doses of ex vivo activated gammadelta T cells do not cause lethal murine graft-vs.-host disease.
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1997
Kawanishi Y, Passweg J, Drobyski WR, Rowlings P, Cook-Craig A, Casper J, Pietryga D, Garbrecht F, Camitta B, Horowitz M, Juckett M, Margolis D, Flomenberg N, Keever-Taylor CA.
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