CD226
From NKcells.info
Contents |
Summary
Ye et al. (2006, PMID:16987076) report that the level of CD226 expression on humans T cells, T Helper cells, cytotoxic T cells and NK cells of HIV patients as well as the level of soluble CD226 in the plasma of patients was significantly higher than that of normal controls. They assume that CD226 may be involved in the immune response to HIV infection.
Ligands
Antibodies
anti-human
Web links
- CD226 / DNAM-1 @ PROW
- Shortcut to this article: http://CD226.nkcells.info
References
Ye X, Zhang Z, Jiang Y, Han X, Wang Y, Zhang M, Liu J, Geng W, Dai D, Shi W, Shang H.
Expression of Human CD226 on T Cells and Natural Killer Cells and of Soluble CD226 in Plasma of HIV-1-Infected Chinese Patients.
Viral Immunol. 2006 Fall;19(3):576-81., PMID:16987076
Jian JL, Zhu CS, Xu ZW, Ouyang WM, Ma DC, Zhang Y, Chen LJ, Yang AG, Jin BQ.
Identification and characterization of CD226 gene promoter.
J Biol Chem. 2006 Aug 2;. Epub, PMID:16887814 NKref0523
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CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions.
J Immunol. 2005 Aug 1;175(3):1558-65. PMID: 16034094
Sun K, Jin BQ, Feng Q, Zhu Y, Yang K, Liu XS, Dong BQ.
Identification of CD226 ligand on colo205 cell surface.
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CD226 mediates platelet and megakaryocytic cell adhesion to vascular endothelial cells.
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Protein kinase C is involved in the regulation of both signaling and adhesion mediated by DNAX accessory molecule-1 receptor.
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DNAM-1, a novel adhesion molecule involved in the cytolytic function of T lymphocytes.
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Pende D, Castriconi R, Romagnani P, Spaggiari GM, Marcenaro S, Dondero A, Lazzeri E, Lasagni L, Martini S, Rivera P, Capobianco A, Moretta L, Moretta A, Bottino C.
Expression of the DNAM-1 ligands, Nectin-2 (CD112) and poliovirus receptor (CD155), on dendritic cells: relevance for natural killer-dendritic cell interaction.
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Tahara-Hanaoka S, Shibuya K, Kai H, Miyamoto A, Morikawa Y, Ohkochi N, Honda S, Shibuya A.
Tumor rejection by the poliovirus receptor family ligands of the DNAM-1 (CD226) receptor.
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Pende D, Bottino C, Castriconi R, Cantoni C, Marcenaro S, Rivera P, Spaggiari GM, Dondero A, Carnemolla B, Reymond N, Mingari MC, Lopez M, Moretta L, Moretta A.
PVR (CD155) and Nectin-2 (CD112) as ligands of the human DNAM-1 (CD226) activating receptor: involvement in tumor cell lysis.
Mol Immunol. 2005 Feb;42(4):463-9., PMID:15607800
Castriconi R, Dondero A, Corrias MV, Lanino E, Pende D, Moretta L, Bottino C, Moretta A.
Natural killer cell-mediated killing of freshly isolated neuroblastoma cells: critical role of DNAX accessory molecule-1-poliovirus receptor interaction.
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Poliovirus receptor CD155-targeted oncolysis of glioma.
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Tahara-Hanaoka S, Shibuya K, Onoda Y, Zhang H, Yamazaki S, Miyamoto A, Honda S, Lanier LL, Shibuya A.
Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112).
Int Immunol. 2004 Apr;16(4):533-8., PMID:15039383
Bottino C, Castriconi R, Pende D, Rivera P, Nanni M, Carnemolla B, Cantoni C, Grassi J, Marcenaro S, Reymond N, Vitale M, Moretta L, Lopez M, Moretta A.
Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule.
J Exp Med. 2003 Aug 18;198(4):557-67. Epub 2003 Aug 11., PMID:12913096 (Free Full Text)
