CEACAM1
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(Redirected from Carcino-embryonic antigen-cell adhesion molecule)
CEACAM1 and diseases
NK-inhibitory receptor CEACAM1 (carcino-embryonic antigen-cell adhesion molecule) is highly expressed among NK cells derived from Ankylosing Spondylitis patients but not from healthy controls. NK cells and CEACAM1 play a role in AS pathogenesis and implicate chemokines (IL-8, SDF-1)in the mechanism of CEACAM1 expression (Azuz-Lieberman, 2005 [1]). CEACAM1 expression is induced by IL-8 and SDF-1 (stromal cell derived factor)(Azuz-Lieberman, 2005 [2]).
References
The involvement of NK cells in ankylosing spondylitis
Azuz-Lieberman, N., Markel, G., Mizrahi, S., Gazit, R., Hanna, J., Achdout, H., Gruda, R., Katz, G., Arnon, T. I., Battat, S., Zamir, E., Adawi, M., Mader, R., Mandelboim, O.
Int Immunol 2005 17: p. 837-845
