CD56dim
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Contents |
Introduction
Effector NK cell subset, mainly responsible for killing of virus infected cells or cancer cells (Cooper et al., 2001)
The number of cytotoxic CD56dim NK cells but not CD56bright immunomodulatory NK cells tripled in a study setting students under psychologic stress by a public-speaking task. Larger increases in NK cells with higher levels of CD16 were found. (Bosch et al., Psychosom Med 2005)
CD56dim cells and diseases
Activated (CD69+) CD56dim NK cells are significantly decreased in patients with sustained virological response against HCV upon therapy with pegylated interferon alpha-2b; activated (CD69+) apoptotic (Annexin-V+) CD56dim NK cells tend to be increased in those patients compared with non-responding patients (Lin et al., 2004).
Further Reading
References
2007
Chan, A., Hong, D.-L., Atzberger, A., Kollnberger, S., Filer, A. D., Buckley, C. D., McMichael, A., Enver, T., Bowness, P.
CD56bright Human NK Cells Differentiate into CD56dim Cells: Role of Contact with Peripheral Fibroblasts
Immunol 2007 179: p. 89-94
Romagnani, C., Juelke, K., Falco, M., Morandi, B., D'Agostino, A., Costa, R., Ratto, G., Forte, G., Carrega, P., Lui, G., Conte, R., Strowig, T., Moretta, A., Munz, C., Thiel, A., Moretta, L., Ferlazzo, G.
CD56brightCD16- Killer Ig-Like Receptor- NK Cells Display Longer Telomeres and Acquire Features of CD56dim NK Cells upon Activation
Immunol 2007 178: p. 4947-4955 NKref0536
2005
Batoni G, Esin S, Favilli F, Pardini M, Bottai D, Maisetta G, Florio W, Campa M.
Human CD56dim and CD56bright Natural Killer Cell Subsets Respond Differentially to Direct Stimulation with Mycobacterium bovis Bacillus Calmette-Guerin.
Scand J Immunol. 2005 Dec;62(6):498-506. PMID: 16316416
Increased Susceptibility to Apoptosis of CD56dimCD16+ NK Cells Induces the Enrichment of IFN-{gamma}-Producing CD56bright Cells in Tuberculous Pleurisy
Schierloh, P., Yokobori, N., Aleman, M., Musella, R. M., Beigier-Bompadre, M., Saab, M. A., Alves, L., Abbate, E., de la Barrera, S. S., Sasiain, M. C.
J Immunol 2005 175: p. 6852-6860
Penack O, Gentilini C, Fischer L, Asemissen AM, Scheibenbogen C, Thiel E, Uharek L.
CD56(dim)CD16(neg) cells are responsible for natural cytotoxicity against tumor targets.
Leukemia. 2005 Mar 03;. PMID: 15744340 (CD107a)
Differential Mobilization of Functionally Distinct Natural Killer Subsets During Acute Psychologic Stress
Bosch, J. A., Berntson, G. G., Cacioppo, J. T., Marucha, P. T.
Psychosom Med 2005 67: p. 366-375
2004
Lin AW, Gonzalez SA, Cunningham-Rundles S, Dorante G, Marshall S, Tignor A, Ha C, Jacobson IM, Talal AH
CD56(+dim) and CD56(+bright) cell activation and apoptosis in hepatitis C virus infection.
Clin Exp Immunol. 2004 Aug;137(2):408-16. PMID: 15270860
Natural killer cell lytic activity and CD56dim and CD56bright cell distributions during and after intensive training
Suzui, M., Kawai, T., Kimura, H., Takeda, K., Yagita, H., Okumura, K., Shek, P. N., Shephard, R. J.
J. Appl. Physiol. 2004 96: p. 2167-2173
2001
Human natural killer cells: a unique innate immunoregulatory role for the CD56bright subset
Cooper, M. A., Fehniger, T. A., Turner, S. C., Chen, K. S., Ghaheri, B. A., Ghayur, T., Carson, W. E., Caligiuri, M. A.
Blood 2001 97: p. 3146-3151
